{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:01:03Z","timestamp":1780480863848,"version":"3.54.1"},"reference-count":44,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana Ricerca Cancro","doi-asserted-by":"crossref","award":["2014-15507"],"award-info":[{"award-number":["2014-15507"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009702","name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Acromegalic patients have an increased vertebral fracture (VFx) risk due to bone quality reduction, independently of bone mineral density (BMD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of the study is to describe bone quality in acromegaly, measured by trabecular bone score (TBS), a noninvasive index for assessing bone microarchitecture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected data from 18 patients (13 female, age 56.2\u2005\u00b1\u200515 years) newly diagnosed with acromegaly. Thirty-six age- and sex-matched healthy controls were also recruited. Pituitary function, bone and calcium-phosphorous metabolism, and BMD at spine and femur and TBS (by dual-energy x-ray absorptiometry) were assessed in acromegalic patients at diagnosis and 12 months after the achievement of insulin-like growth factor 1 (IGF-1) normalization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At diagnosis, BMD and the VFx prevalence were comparable between patients and controls (28.3\u2005\u00b1\u20055.9 vs 27.6\u2005\u00b1\u20053.7 and 11% vs 8.3%), whereas TBS was significantly lower in acromegalic patients (1.20\u2005\u00b1\u20050.13 vs 1.30\u2005\u00b1\u20050.06; P\u2005&amp;lt;\u2005.001) and carboxyterminal telopeptide (CTX) and osteocalcin were significantly higher compared to controls (707\u2005\u00b1\u2005365.7 vs 371\u2005\u00b1\u2005104.1 pg\/mL; P\u2005=\u2005.001 and 31.6\u2005\u00b1\u200515.4 vs 17.0\u2005\u00b1\u20055.7 ng\/mL; P\u2005=\u2005.001, respectively). One year after IGF-1 normalization, a significant reduction of bone turnover indexes was observed in the group of acromegalic patients surgically cured (osteocalcin decrease of 61.2%, CTX decrease of 60.3%) compared to the ones controlled by medical therapy (osteocalcin decrease of 39%, CTX decrease of 40.7%; P\u2005=\u2005.01 and P\u2005=\u2005.001, respectively). Despite these findings, no TBS or BMD variations were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Acromegalic patients have impaired bone quality despite normal density. Achieving normal growth hormone secretion rapidly leads to the normalization of bone turnover.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvab090","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T03:28:20Z","timestamp":1621049300000},"source":"Crossref","is-referenced-by-count":17,"title":["Spine Bone Texture Assessed by Trabecular Bone Score in Active and Controlled Acromegaly: A Prospective Study"],"prefix":"10.1210","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-9293","authenticated-orcid":false,"given":"E","family":"Sala","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Malchiodi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, 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