{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:57:16Z","timestamp":1791496636664,"version":"4.3.4"},"reference-count":65,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H06428"],"award-info":[{"award-number":["17H06428"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2019A-1"],"award-info":[{"award-number":["2019A-1"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Recent studies have revealed that every eukaryotic cell contains several membraneless organelles created via liquid\u2013liquid phase separation (LLPS). LLPS is a physical phenomenon that transiently compartmentalizes the subcellular space and thereby facilitates various biological reactions. LLPS is indispensable for cellular functions; however, dysregulated LLPS has the potential to cause irreversible protein aggregation leading to degenerative disorders. To date, there is no systematic review on the role of LLPS in endocrinology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence acquisition<\/jats:title><jats:p>We explored previous studies which addressed roles of LLPS in living cells, particularly from the viewpoint of endocrinology. To this end, we screened relevant literature in PubMed published between 2009 and 2021 using LLPS-associated keywords including \u201cmembraneless organelle,\u201d \u201cphase transition,\u201d and \u201cintrinsically disordered,\u201d and endocrinological keywords such as \u201chormone,\u201d \u201covary,\u201d \u201candrogen,\u201d and \u201cdiabetes.\u201d We also referred to the articles in the reference lists of identified papers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence synthesis<\/jats:title><jats:p>Based on 67 articles selected from 449 papers, we provided a concise overview of the current understanding of LLPS in living cells. Then, we summarized recent articles documenting the physiological or pathological roles of LLPS in endocrine cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The discovery of LLPS in cells has resulted in a paradigm shift in molecular biology. Recent studies indicate that LLPS contributes to male sex development by providing a functional platform for SOX9 and CBX2 in testicular cells. In addition, dysregulated LLPS has been implicated in aberrant protein aggregation in pancreatic \u03b2-cells, leading to type 2 diabetes. Still, we are just beginning to understand the significance of LLPS in endocrine cells.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jendso\/bvab126","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T10:24:26Z","timestamp":1626690266000},"source":"Crossref","is-referenced-by-count":10,"title":["Role of Liquid\u2013Liquid Separation in Endocrine and Living Cells"],"prefix":"10.1210","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3561-2552","authenticated-orcid":false,"given":"Kazuhisa","family":"Akiba","sequence":"first","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, 157-8535 Tokyo, Japan"},{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children\u2019s Medical Center, 183-8561 Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Katoh-Fukui","sequence":"additional","affiliation":[{"name":"Department 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