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Adult female acne, however, in the dermatological literature is considered as an inflammatory skin disease and new guidelines on adult female acne have been produced by dermatological societies, with little perspective from any endocrine or reproductive endocrine points of view. An expert task force was appointed by the AE-PCOS society to determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female adult acne. The following are the recommendations (level of evidence A or B): (1) diagnosis of female adult acne is mainly clinical, but a grading tool is needed for optimizing the treatment; (2) measurement of serum androgen values (total testosterone, free testosterone, and dehydroepiandrosterone sulfate) by high-quality assays is recommended in all women with adult acne; (3) in women with adult acne and proven hyperandrogenism, oral combined estroprogestins should be added to the topical or systemic treatment of acne, independently of severity of acne; (4) all second- and third-generation estroprogestins may be used, independently of the estrogen dose and progestin component; (5) spironolactone may be added to estroprogestins in women with moderate or severe hyperandrogenic adult acne, not responding to usual treatments; (6) estroprogestins may be used in nonhyperandrogenic patients with adult acne as second-line therapy.<\/jats:p>","DOI":"10.1210\/jendso\/bvac003","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T01:55:02Z","timestamp":1644371702000},"source":"Crossref","is-referenced-by-count":60,"title":["Female Adult Acne and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee"],"prefix":"10.1210","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-7610","authenticated-orcid":false,"given":"Enrico","family":"Carmina","sequence":"first","affiliation":[{"name":"Endocrinology Unit, University of Palermo Medical School , Palermo, 90139 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Dreno","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Nantes Medical School , Nantes, 44093 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Anne","family":"Lucky","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Cincinnati College of Medicine and Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W George","family":"Agak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology, University of California (UCLA) , Los Angeles, CA 90035 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Dokras","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Perelman School of Medicine of the University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital 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