{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:39Z","timestamp":1753883619132,"version":"3.41.2"},"reference-count":40,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Small-for-gestational-age (SGA) children have a particular metabolic and hormonal pattern at birth that changes rapidly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the linear and weight growth in the first year of life in SGA children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective, monocentric cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Real-world data collected from April 2012 to January 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>SGA newborns uniformly defined by either growth or length lower than -2 SDs for gestational age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>All children were evaluated for 1 year after birth, at 3 days of life, then 3, 6, and 12 months after birth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Anthropometric parameters and biochemical variables, such as blood glucose, insulin, leptin, IGF-1, IGF binding protein-3 (IGFBP-3), and homeostasis model assessment - insulin resistance (HOMA-IR) index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 133 SGA children were enrolled. Length significantly improved 1 month after birth, whereas weight significantly increased only at 3 months after birth. Biochemical variables increased during the first year of life, showing a prediction by IGFBP-3 and HOMA-IR index. Then, the variables were divided considering either weight, length, or both, showing a different incidence. The biochemical variable changes recorded in the first step were maintained considering SGA children for weight or length, whereas they disappeared when weight and length were considered together.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study shows a specific catchup growth for weight and length in SGA children. Moreover, we highlight that weight and length should be considered as independent parameters in SGA children, defining 2 different metabolic-hormonal populations with different conceivable predictive role in early catchup growth and in later growth and metabolic status.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvac028","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:50:52Z","timestamp":1645476652000},"source":"Crossref","is-referenced-by-count":0,"title":["First Year Metabolic and Hormonal Behavior Define two Different Populations of SGA Newborn for Weight or Height"],"prefix":"10.1210","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-0109","authenticated-orcid":false,"given":"Laura","family":"Guazzarotti","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Pediatric Department, University of Padua, 35122, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Mauri","sequence":"additional","affiliation":[{"name":"Pediatric Department, University of Milan \u201cV Buzzi\u201d Children\u2019s Hospital ASST FBF Sacco, 20157, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Santi","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pogliani","sequence":"additional","affiliation":[{"name":"Pediatric Department, Legnano Hospital, Milan, 20025, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianvincenzo","family":"Zuccotti","sequence":"additional","affiliation":[{"name":"Pediatric Department, University of Milan \u201cV Buzzi\u201d Children\u2019s Hospital ASST FBF Sacco, 20157, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"issue":"10","key":"2022032516130501400_CIT0001","doi-asserted-by":"crossref","first-page":"e0258967","DOI":"10.1371\/journal.pone.0258967","article-title":"Incidence, risk factors, and feto-maternal outcomes of inappropriate birth weight for gestational age among singleton live births in Qatar: a population-based study","volume":"16","author":"Younes","year":"2021","journal-title":"PLoS One."},{"issue":"9","key":"2022032516130501400_CIT0002","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/jech-2014-205387","article-title":"Mother\u2019s education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts","volume":"69","author":"Ruiz","year":"2015","journal-title":"J Epidemiol Community Health."},{"issue":"1","key":"2022032516130501400_CIT0003","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13052-021-01026-3","article-title":"Prevalence of children born small for gestational age with short stature who qualify for growth hormone treatment","volume":"47","author":"Tamaro","year":"2021","journal-title":"Ital J Pediatr"},{"issue":"5","key":"2022032516130501400_CIT0004","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/ped.12859","article-title":"Prevalence of small for gestational age (SGA) and short stature in children born SGA who qualify for growth hormone treatment at 3 years of age: population-based study","volume":"58","author":"Fujita","year":"2016","journal-title":"Pediatr Int."},{"issue":"7","key":"2022032516130501400_CIT0005","first-page":"2021","article-title":"Clinical review 89: small as fetus and short as child: from endogenous to exogenous growth hormone","volume":"82","author":"de Zegher","year":"1997","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2022032516130501400_CIT0006","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1203\/00006450-199508000-00022","article-title":"Children born small for gestational age: do they catch up?","volume":"38","author":"Hokken-Koelega","year":"1995","journal-title":"Pediatr Res."},{"issue":"3","key":"2022032516130501400_CIT0007","first-page":"337","article-title":"Are children born small for gestational age at increased risk of short stature?","volume":"147","author":"Paz","year":"1993","journal-title":"Am. 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