{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:48:22Z","timestamp":1787021302600,"version":"build-2736575974"},"reference-count":20,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a successful pregnancy in a young woman with autosomal dominant hypoparathyroidism type 1 (ADH1) due to an activating mutation of the calcium sensing receptor (CASR) (c.2519C&amp;gt;T; p.Ala840Val) who was treated with recombinant human parathyroid hormone (rhPTH)1-34 delivered via continuous subcutaneous infusion using an OmniPod pump. She experienced no tetany or hospitalizations during the pregnancy. Serum calcium levels ranged from 7.2 to 9.8 mg\/dL. Due to mild preeclampsia, her infant was delivered at 37 weeks. There were no physical anomalies. The patient continued pump therapy while nursing her daughter, who was ultimately confirmed to have the same CASR mutation. Breastfeeding appeared to protect the infant from significant hypocalcemia without the need for calcium or calcitriol supplementation until weaning at a year of age. A role for parathyroid hormone-related protein (PTHrP) is suggested.<\/jats:p>","DOI":"10.1210\/jendso\/bvac031","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T13:46:38Z","timestamp":1645796798000},"source":"Crossref","is-referenced-by-count":12,"title":["Subcutaneous Infusion of rhPTH1-34 During Pregnancy and Nursing in a Woman With Autosomal Dominant Hypoparathyroidism 1"],"prefix":"10.1210","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-6916","authenticated-orcid":false,"given":"Dorothy","family":"Shulman","sequence":"first","affiliation":[{"name":"University of South Florida Diabetes and Endocrinology Center, USF Morsani College of Medicine, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"issue":"7","key":"2022032516131562500_CIT0001","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3390\/jcm10071378","article-title":"Hypoparathyroidism in pregnancy and lactation: current approach to diagnosis and management","volume":"10","author":"Ali","year":"2021","journal-title":"J Clin Med."},{"issue":"12","key":"2022032516131562500_CIT0002","first-page":"e5054","article-title":"Changes in serum calcium and treatment of hypoparathyroidism during pregnancy and lactation: a single-center case series","volume":"106","author":"Wang","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"key":"2022032516131562500_CIT0003","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bonr.2015.05.005","article-title":"Management of hypoparathyroidism in pregnancy and lactation- a report of 10 cases","volume":"3","author":"Hatswell","year":"2015","journal-title":"Bone Rep."},{"key":"2022032516131562500_CIT0004","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1210\/clinem\/dgab503","article-title":"Women with chronic hypoparathyroidism have low risk of adverse pregnancy outcomes","volume":"106","author":"Bjornsdottir","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"key":"2022032516131562500_CIT0005","volume-title":"Natpara [package insert]","year":"2020"},{"key":"2022032516131562500_CIT0006","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1056\/NEJMcp1800213","article-title":"Hypoparathyroidism","volume":"380","author":"Gafni","year":"2019","journal-title":"N Engl J Med."},{"issue":"6","key":"2022032516131562500_CIT0007","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1210\/jc.2015-3910","article-title":"Management of hypoparathyroidism: present and future","volume":"101","author":"Bilezikian","year":"2016","journal-title":"J Clin 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synthetic parathyroid hormone 1-34 in children with severe congenital hypoparathyroidism","volume":"165","author":"Winer","year":"2014","journal-title":"J Pediatr."},{"key":"2022032516131562500_CIT0012","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ki.1989.168","article-title":"Gestational hypercalciuria causes pathological urine calcium oxalate supersaturations","volume":"36","author":"Maikranz","year":"1989","journal-title":"Kidney Int."},{"issue":"3","key":"2022032516131562500_CIT0013","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1053\/j.ajkd.2021.01.008","article-title":"Risk of symptomatic kidney stones during and after pregnancy","volume":"78","author":"Thongprayoon","year":"2021","journal-title":"Am J Kidney Dis."},{"issue":"3","key":"2022032516131562500_CIT0014","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4158\/EP09337.CR","article-title":"Decreased calcitriol requirement during pregnancy and lactation with a window of increased 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