{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:38:23Z","timestamp":1788489503993,"version":"build-2803163510"},"reference-count":28,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Among the side effects of methimazole (MMI) for the treatment of Graves\u2019 disease, MMI-induced acute pancreatitis (MIP) is a rare adverse reaction, with only 7 cases being reported to date. However, 2 large-scale population-based studies recently revealed that the risk of MIP was significantly higher, ranging from 0.02% to 0.56%. Although MIP is common in middle-aged and elderly Asian women, its pathogenesis remains largely unknown. We herein present a case of a 72-year-old Japanese woman with Graves\u2019 disease who developed MIP 12 days after the initiation of MMI. The MMI was discontinued, the patient was switched to propylthiouracil (PTU) therapy, and pancreatitis gradually resolved. Serological human leukocyte antigen (HLA) typing identified HLA-DRB1*08:03:02. This HLA allele was previously detected in a patient with MIP and is one of the major risk factors for agranulocytosis induced by antithyroid drugs, including PTU as well as MMI. In cases of MIP, PTU is being considered as an alternative to MMI; however, its safety needs further investigation and patients require close monitoring after the switch to PTU. Further studies are warranted, particularly on the relationship between MIP and the presence of HLA alleles causing antithyroid drug-induced agranulocytosis.<\/jats:p>","DOI":"10.1210\/jendso\/bvac038","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T13:36:32Z","timestamp":1646919392000},"source":"Crossref","is-referenced-by-count":8,"title":["A Case of Methimazole-Induced Acute Pancreatitis With an HLA Allele Causing Antithyroid Drug-Induced Agranulocytosis"],"prefix":"10.1210","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-9747","authenticated-orcid":false,"given":"Yusuke","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Tatsushima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Goshima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Toranomon Hospital, Minato-Ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikako","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Toranomon Hospital, Minato-Ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunao","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Toranomon Hospital, Minato-Ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-9055","authenticated-orcid":false,"given":"Akira","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"},{"name":"Okinaka Memorial Institute for Medical Research, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"issue":"5","key":"2022040717023287000_CIT0001","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1046\/j.1365-2265.1999.00888.x","article-title":"Acute pancreatitis and parotitis induced by methimazole in a patient with Graves\u2019 disease","volume":"51","author":"Taguchi","year":"1999","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"3","key":"2022040717023287000_CIT0002","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1507\/endocrj.49.315","article-title":"Acute pancreatitis, hepatic cholestasis, and erythema nodosum induced by carbimazole treatment for Graves\u2019 disease","volume":"49","author":"Marazuela","year":"2002","journal-title":"Endocr J."},{"issue":"1","key":"2022040717023287000_CIT0003","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1089\/thy.2011.0210","article-title":"Acute pancreatitis induced by methimazole in a patient with Graves\u2019 disease","volume":"22","author":"Yang","year":"2012","journal-title":"Thyroid."},{"issue":"2","key":"2022040717023287000_CIT0004","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000338652","article-title":"Acute pancreatitis induced by methimazole therapy","volume":"6","author":"Abraham","year":"2012","journal-title":"Case Rep Gastroenterol."},{"issue":"8","key":"2022040717023287000_CIT0005","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3346\/jkms.2014.29.8.1170","article-title":"Acute pancreatitis induced by methimazole treatment in a 51-year-old Korean man: a case report","volume":"29","author":"Jung","year":"2014","journal-title":"J Korean Med Sci."},{"issue":"2","key":"2022040717023287000_CIT0006","first-page":"1","article-title":"Acute pancreatitis induced by methimazole in a patient with subclinical hyperthyroidism","volume":"3","author":"Agito","year":"2015","journal-title":"J Investig Med High Impact Case Rep."},{"issue":"3","key":"2022040717023287000_CIT0007","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12328-018-0926-5","article-title":"Methimazole-induced acute pancreatitis: a case report","volume":"12","author":"Kikuchi","year":"2019","journal-title":"Clin J Gastroenterol."},{"key":"2022040717023287000_CIT0008","author":"European Medicines Agency"},{"issue":"3","key":"2022040717023287000_CIT0009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S2213-8587(20)30025-5","article-title":"Methimazole and risk of acute pancreatitis","volume":"8","author":"Brix","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"12","key":"2022040717023287000_CIT0010","doi-asserted-by":"crossref","first-page":"e4527","DOI":"10.1210\/clinem\/dgaa544","article-title":"Methimazole treatment and risk of acute pancreatitis: a population-based cohort study","volume":"105","author":"Pecere","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2022040717023287000_CIT0011","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2036.1996.tb00174.x","article-title":"Review article: drug-induced pancreatitis","volume":"10","author":"McArthur","year":"1996","journal-title":"Aliment Pharmacol Ther."},{"key":"2022040717023287000_CIT0012","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1100\/tsw.2007.98","article-title":"TNF-alpha as a therapeutic target in acute pancreatitis--lessons from experimental models","volume":"7","author":"Malleo","year":"2007","journal-title":"Sci World J."},{"issue":"1","key":"2022040717023287000_CIT0013","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00006676-199607000-00003","article-title":"Calcium channel blockade inhibits release of TNF alpha and improves survival in a rat model of acute pancreatitis","volume":"13","author":"Hughes","year":"1996","journal-title":"Pancreas."},{"issue":"2","key":"2022040717023287000_CIT0014","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<117::AID-PATH494>3.0.CO;2-K","article-title":"Inflammatory mediators in acute pancreatitis","volume":"190","author":"Bhatia","year":"2000","journal-title":"J Pathol."},{"issue":"11","key":"2022040717023287000_CIT0015","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1089\/thy.2019.0589","article-title":"Association between thionamides and acute pancreatitis: a case\u2013control study","volume":"30","author":"Guo","year":"2020","journal-title":"Thyroid."},{"issue":"5","key":"2022040717023287000_CIT0016","doi-asserted-by":"crossref","first-page":"490","DOI":"10.7326\/0003-4819-124-5-199603010-00005","article-title":"Association between the DRB1*08032 histocompatibility antigen and methimazole-induced agranulocytosis in Japanese patients with Graves disease","volume":"124","author":"Tamai","year":"1996","journal-title":"Ann Intern Med"},{"key":"2022040717023287000_CIT0017","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.1038\/ncomms8633","article-title":"Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study","volume":"6","author":"Chen","year":"2015","journal-title":"Nat Commun."},{"issue":"6","key":"2022040717023287000_CIT0018","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S2213-8587(16)00113-3","article-title":"Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population","volume":"4","author":"Hallberg","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"2022040717023287000_CIT0019","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/cpt.309","article-title":"HLA-B*38:02:01 predicts carbimazole\/methimazole-induced agranulocytosis","volume":"99","author":"Cheung","year":"2016","journal-title":"Clin Pharmacol Ther."},{"issue":"1","key":"2022040717023287000_CIT0020","doi-asserted-by":"crossref","first-page":"11950","DOI":"10.1038\/s41598-017-12350-2","article-title":"Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China","volume":"7","author":"He","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"2022040717023287000_CIT0021","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41397-020-00187-4","article-title":"HLA-B*39:01:01 is a novel risk factor for antithyroid drug-induced agranulocytosis in Japanese population","volume":"21","author":"Nakakura","year":"2021","journal-title":"Pharmacogenomics J."},{"key":"2022040717023287000_CIT0022","doi-asserted-by":"crossref","first-page":"109095","DOI":"10.1016\/j.biopha.2019.109095","article-title":"Association of HLA-C*03:02 with methimazole-induced liver injury in Graves\u2019 disease patients","volume":"117","author":"Li","year":"2019","journal-title":"Biomed Pharmacother."},{"issue":"6","key":"2022040717023287000_CIT0023","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0168-8278(05)80617-8","article-title":"DNA typing of HLA class II genes; DRB1*0803 increases the susceptibility of Japanese to primary biliary cirrhosis","volume":"21","author":"Onishi","year":"1994","journal-title":"J Hepatol."},{"issue":"4","key":"2022040717023287000_CIT0024","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/s101650070009","article-title":"Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus","volume":"10","author":"Morimoto","year":"2000","journal-title":"Mod Rheumatol"},{"issue":"D1","key":"2022040717023287000_CIT0025","first-page":"D783","article-title":"Allele frequency net database (AFND) 2020 update: Gold-standard data classification, open access genotype data and new query tools","volume":"48","author":"Gonzalez-Galarza","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022040717023287000_CIT0026","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0016-5085(65)80088-9","article-title":"Diagnostic value of a new serum lipase method","volume":"48","author":"Ticktin","year":"1965","journal-title":"Gastroenterology."},{"key":"2022040717023287000_CIT0027","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0016-5085(64)80084-6","article-title":"Clinical value of determinations of various pancreatic enzymes in serum","volume":"46","author":"Zieve","year":"1964","journal-title":"Gastroenterology."},{"issue":"3","key":"2022040717023287000_CIT0028","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1084\/jem.180.3.873","article-title":"Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome","volume":"180","author":"Matsushita","year":"1994","journal-title":"J Exp Med."}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvac038\/42807659\/bvac038.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/6\/5\/bvac038\/43298323\/bvac038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/6\/5\/bvac038\/43298323\/bvac038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T13:03:11Z","timestamp":1649336591000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvac038\/6546658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvac038","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5,1]]},"published":{"date-parts":[[2022,3,10]]},"article-number":"bvac038"}}