{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:30:33Z","timestamp":1775766633871,"version":"3.50.1"},"reference-count":54,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Uterine leiomyomas are benign monoclonal tumors originating from the myometrium. Little information exists concerning metabolomics and the presence of leiomyomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The present study evaluated circulating metabolites in the plasma and their correlation with the presence and size of leiomyomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>Cross-sectional observational study, including women divided into 3 groups: 37 with leiomyomas and uterus &amp;gt;500 cm3, 17 with leiomyomas and uterus \u2264150 cm3, and 21 leiomyoma-free. Patients underwent peripheral blood collection using untargeted metabolic assessment by gas chromatography coupled to mass spectrometer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was no statistical difference between patients\u2019 anthropometric and demographic features and laboratory tests. Statistical differences in uterus volume (P\u2005&amp;lt;\u20050.0001) were found. Forty-six metabolites were identified (35% amino acids and derivatives, 22% fatty acids, and 18% carbohydrates). Statistically significant metabolic distinction (P\u2005&amp;lt;\u20050.05, false discovery rate&amp;lt;\u20050.05) was observed for 14 metabolites. Most amino acids (L-isoleucine, L-valine, and pyroglutamic acid) were significantly reduced in plasma levels of patients with large leiomyomas. The only exception was L-glutamine, with a significant increase. Fatty acids (arachidonic acid, alfa-tocopherol, palmitic acid, and stearic acid) were similarly reduced in large leiomyomas patients, except for alpha-linolenic acid, which increased. For carbohydrates (myo-inositol, D-threitol, and D-ribose), there was a decrease in the plasma of patients with leiomyomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There are different plasma metabolites levels of amino acids, fatty acids, and carbohydrates among patients with leiomyomas, most of them reduced, but some significantly increased in large leiomyomas, compared to leiomyoma-free patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvac061","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T15:13:06Z","timestamp":1649949186000},"source":"Crossref","is-referenced-by-count":11,"title":["Metabolomic Profiling of Peripheral Plasma by GC-MS and Correlation With Size of Uterine Leiomyomas"],"prefix":"10.1210","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6865-3468","authenticated-orcid":false,"given":"Gustavo Anderman Silva","family":"Barison","sequence":"first","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3379-5802","authenticated-orcid":false,"given":"Paulo","family":"D\u2019Amora","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio Augusto","family":"Izidoro","sequence":"additional","affiliation":[{"name":"Spectrometry Laboratory; Beneficent Association for Blood Collection (COLSAN), Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-5340","authenticated-orcid":false,"given":"Mariana","family":"Corinti","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-8126","authenticated-orcid":false,"given":"Lu\u00edsa Marcella","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-5576","authenticated-orcid":false,"given":"Claudio Em\u00edlio","family":"Bonduki","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo de Aquino","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-9377","authenticated-orcid":false,"given":"Manoel Jo\u00e3o Batista Castello","family":"Gir\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-4311","authenticated-orcid":false,"given":"Mariano Tamura Vieira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"2022052105453242000_CIT0001","volume-title":"Mioma uterino. 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