{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:29:43Z","timestamp":1775258983839,"version":"3.50.1"},"reference-count":84,"publisher":"The Endocrine Society","issue":"11","funder":[{"name":"United States Veteran Administration Merit Review","award":["01BX001966"],"award-info":[{"award-number":["01BX001966"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Thyroid hormone has been shown to have a protective role in neuronal injury, although the mechanisms have not been established. The cellular response to stress that promotes adaptation and survival has been shown to involve epigenetic modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We hypothesized that the neuroprotective role of thyroid hormone was associated with epigenetic modifications of histone proteins. We used hypoxic neurons as a model system for hypoxia-induced brain injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mouse primary cortical neurons were exposed to 0.2% oxygen for 7\u2005hours, with or without, treatment with triiodothyronine (T3). We analyzed the expression of histone-modifying enzymes by RNA-seq and the post-translationally modified histone 3 proteins by enzyme-linked immunosorbent assay (ELISA) and Western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that methylation of H3K27, associated with inactive promoters, was highly induced in hypoxic neurons, and this histone methylation was reduced by T3 treatment. H3K4 methylation is the hallmark of active promoters. The expression of 3 (Set1db, Kmta2c, and Kmt2e) out of 6 H3K4 methyltransferases was downregulated by hypoxia and expression was restored by T3 treatment. H3K4me3 protein, measured by ELISA, was increased 76% in T3-treated hypoxic neurons compared with the levels without T3 treatment. H3K56ac plays a critical role in transcription initiation and was markedly increased in T3-treated hypoxic neurons compared with those without T3 treatment, indicating stimulation of gene transcription. Additionally, T3 treatment restored hypoxia-induced downregulation of histone acetyltransferase, Kat6a, Kat6b, and Crebbp, which function as transcription factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings indicate that T3 treatment mitigates hypoxia-induced histone modifications and protects neurons from hypoxia-induced injury.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jendso\/bvac139","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T08:15:29Z","timestamp":1663056929000},"source":"Crossref","is-referenced-by-count":12,"title":["Thyroid Hormone\u2013mediated Histone Modification Protects Cortical Neurons From the Toxic Effects of Hypoxic Injury"],"prefix":"10.1210","volume":"6","author":[{"given":"Kiyomi","family":"Abe","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA , Los Angeles, CA 90095 , USA"},{"name":"Veterans Affairs Greater Los Angeles Healthcare System , Los Angeles, CA 90073 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA , Los Angeles, CA 90095 , USA"},{"name":"Veterans Affairs Greater Los Angeles Healthcare System , Los Angeles, CA 90073 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-2275","authenticated-orcid":false,"given":"Yan Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA , Los Angeles, CA 90095 , USA"},{"name":"Veterans Affairs Greater Los Angeles Healthcare System , Los Angeles, CA 90073 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-6645","authenticated-orcid":false,"given":"Gregory A","family":"Brent","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA , Los Angeles, CA 90095 , USA"},{"name":"Veterans Affairs Greater Los Angeles Healthcare System , Los Angeles, CA 90073 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"issue":"4","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp Mol Med"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral thinking: how histone modifications regulate gene expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet"},{"issue":"17","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1101\/gad.303768.117","article-title":"Histone H3K4 methylation-dependent and -independent functions of Set1A\/COMPASS in embryonic stem cell self-renewal and differentiation","volume":"31","author":"Sze","year":"2017","journal-title":"Genes Dev"},{"issue":"11","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S1097-2765(03)00479-9","article-title":"Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains","volume":"12","author":"Rice","year":"2003","journal-title":"Mol Cell"},{"issue":"4","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.molcel.2017.10.013","article-title":"Determinants of histone H3K4 methylation patterns","volume":"68","author":"Soares","year":"2017","journal-title":"Mol Cell"},{"issue":"10","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/ng.3385","article-title":"Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes","volume":"47","author":"Chen","year":"2015","journal-title":"Nat Genet"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fcvm.2020.00028","article-title":"Epigenetic control of mitochondrial function in the vasculature","volume":"7","author":"Mohammed","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mrrev.2016.03.005","article-title":"The many faces of histone H3K79 methylation","volume":"768(April-June)","author":"Farooq","year":"2016","journal-title":"Mutat Res Rev Mutat Res"},{"issue":"20","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1111\/febs.14198","article-title":"Structural insight into the recognition of acetylated histone H3K56ac mediated by the bromodomain of CREB-binding protein","volume":"284","author":"Xu","year":"2017","journal-title":"FEBS J"},{"issue":"7388","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10849","article-title":"An epigenetic blockade of cognitive functions in the neurodegenerating brain","volume":"483","author":"Graff","year":"2012","journal-title":"Nature"},{"key":"2023021717293146600_","first-page":"613098","article-title":"Impaired regulation of histone methylation and acetylation underlies specific neurodevelopmental disorders","volume":"11(Jan 8)","author":"Fallah","year":"2020","journal-title":"Front Genet"},{"issue":"6","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00439-011-1004-y","article-title":"A mutation screen in patients with kabuki syndrome","volume":"130","author":"Li","year":"2011","journal-title":"Hum Genet"},{"issue":"9","key":"2023021717293146600_","first-page":"725","article-title":"A probable case of familial weaver syndrome associated with neoplasia","volume":"36","author":"Derry","year":"1999","journal-title":"J Med Genet"},{"issue":"37","key":"2023021717293146600_","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025281118","article-title":"Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist","volume":"118","author":"Liu","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2217\/epi.15.24","article-title":"Epigenetic regulation by histone demethylases in hypoxia","volume":"7","author":"Hancock","year":"2015","journal-title":"Epigenomics"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1749-6632.2009.05027.x","article-title":"Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases","volume":"1177","author":"Yang","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"6432","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1126\/science.aau5870","article-title":"Hypoxia induces rapid changes to histone methylation and reprograms chromatin","volume":"363","author":"Batie","year":"2019","journal-title":"Science"},{"issue":"4","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1021\/acschembio.6b00958","article-title":"The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations","volume":"12","author":"Hancock","year":"2017","journal-title":"ACS Chem Biol"},{"issue":"33","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"E7871","DOI":"10.1073\/pnas.1800680115","article-title":"Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart","volume":"115","author":"Warren","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6432","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.aaw1026","article-title":"Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate","volume":"363","author":"Chakraborty","year":"2019","journal-title":"Science"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1038\/s41598-017-11658-3","article-title":"KDM4A regulates HIF-1 levels through H3K9me3","volume":"7","author":"Dobrynin","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/BJ20140754","article-title":"Chromatin and oxygen sensing in the context of JmjC histone demethylases","volume":"462","author":"Shmakova","year":"2014","journal-title":"Biochem J"},{"issue":"6","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41580-019-0122-6","article-title":"Hypoxia makes its mark on histones","volume":"20","author":"Strzyz","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1210\/en.2011-1736","article-title":"Liganded thyroid hormone receptor induces nucleosome removal and histone modifications to activate transcription during larval intestinal cell death and adult stem cell development","volume":"153","author":"Matsuura","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1038\/s41467-021-24748-8","article-title":"Neonatal thyroxine activation modifies epigenetic programming of the liver","volume":"12","author":"Fonseca","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"e9853","DOI":"10.1371\/journal.pone.0009853","article-title":"Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"issue":"10","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1210\/en.2019-00125","article-title":"Thyroid hormone protects primary cortical neurons exposed to hypoxia by reducing DNA methylation and apoptosis","volume":"160","author":"Li","year":"2019","journal-title":"Endocrinology"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2017.05.023","article-title":"Thyroid hormone treatment activates protective pathways in both in vivo and in vitro models of neuronal injury","volume":"452","author":"Li","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pharmthera.2018.01.007","article-title":"Thyroid hormone and the brain: mechanisms of action in development and role in protection and promotion of recovery after brain injury","volume":"186(June)","author":"Liu","year":"2018","journal-title":"Pharmacol Therap"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/cphy.c200019","article-title":"The role of thyroid hormone in neuronal protection","volume":"11","author":"Liu","year":"2021","journal-title":"Compr Physiol"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3389\/fneur.2019.01103","article-title":"Thyroid hormones in the brain and their impact in recovery mechanisms after stroke","volume":"10(October)","author":"Talhada","year":"2019","journal-title":"Front Neurol"},{"key":"2023021717293146600_","first-page":"e4285","article-title":"A visual description of the dissection of the cerebral surface vasculature and associated meninges and the choroid plexus from rat brain","volume":"69(Nov 14)","author":"Bowyer","year":"2012","journal-title":"J Vis Exp"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/s41467-018-06222-0","article-title":"Single cell molecular alterations reveal target cells and pathways of concussive brain injury","volume":"9","author":"Arneson","year":"2018","journal-title":"Nat Commun"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.pneurobio.2011.01.007","article-title":"Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species","volume":"93","author":"Vieira","year":"2011","journal-title":"Prog Neurobiol"},{"issue":"8","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.1016\/S0021-9258(17)37547-6","article-title":"Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue-specific regulation of GLUT4 expression by thyroid hormone","volume":"269","author":"Castello","year":"1994","journal-title":"J Biol Chem"},{"issue":"2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1677\/joe.0.1640187","article-title":"Stimulation of glucose transport by thyroid hormone in 3T3-L1 adipocytes: increased abundance of GLUT1 and GLUT4 glucose transporter proteins","volume":"164","author":"Romero","year":"2000","journal-title":"J Endocrinol"},{"issue":"6","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1159\/000484386","article-title":"Transient congenital hypothyroidism alters gene expression of glucose transporters and impairs glucose sensing apparatus in young and aged offspring rats","volume":"43","author":"Gholami","year":"2017","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1530\/JOE-16-0424","article-title":"Thyroid hormone regulated genes in cerebral cortex development","volume":"232","author":"Bernal","year":"2017","journal-title":"J Endocrinol"},{"issue":"19","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1158\/0008-5472.CAN-07-1525","article-title":"Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping egr-1\/Sp1 binding site in the promoter","volume":"67","author":"Zhang","year":"2007","journal-title":"Cancer Res"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1038\/s41467-019-11905-3","article-title":"EGR1 Recruits TET1 to shape the brain methylome during development and upon neuronal activity","volume":"10","author":"Sun","year":"2019","journal-title":"Nat Commun"},{"issue":"4","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-biochem-051710-134100","article-title":"The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis","volume":"81(July)","author":"Shilatifard","year":"2012","journal-title":"Annu Rev Biochem"},{"issue":"11","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1128\/MCB.25.11.4650-4661.2005","article-title":"Mapping global histone methylation patterns in the coding regions of human genes","volume":"25","author":"Miao","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cell.2005.01.001","article-title":"Genomic maps and comparative analysis of histone modifications in human and mouse","volume":"120","author":"Bernstein","year":"2005","journal-title":"Cell"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13578-020-0374-z","article-title":"H3k36me3, message from chromatin to DNA damage repair","volume":"10","author":"Sun","year":"2020","journal-title":"Cell Biosci"},{"issue":"2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.emboj.7601967","article-title":"Dynamic histone H3 methylation during gene induction: HYPB\/Setd2 mediates all H3K36 trimethylation","volume":"27","author":"Edmunds","year":"2008","journal-title":"EMBO J"},{"issue":"8","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1074\/jbc.M111.328138","article-title":"Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation","volume":"287","author":"Kim","year":"2012","journal-title":"J Biol Chem"},{"issue":"6","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.molcel.2007.12.004","article-title":"Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly","volume":"28","author":"Onishi","year":"2007","journal-title":"Mol Cell"},{"issue":"10","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1096\/fj.201800242R","article-title":"KDM2B Is a histone H3K79 demethylase and induces transcriptional repression via sirtuin-1-mediated chromatin silencing","volume":"32","author":"Kang","year":"2018","journal-title":"FASEB J"},{"issue":"1","key":"2023021717293146600_","first-page":"31","article-title":"HDAC9 Is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells","volume":"1","author":"Lang","year":"2012","journal-title":"Am J Stem Cells"},{"key":"2023021717293146600_","first-page":"544285","article-title":"HDAC9 Silencing exerts neuroprotection against ischemic brain injury via miR-20a-dependent downregulation of NeuroD1","volume":"14(Jan 11)","author":"Zhong","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jnr.23170","article-title":"Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability","volume":"91","author":"Price","year":"2013","journal-title":"J Neurosci Res"},{"issue":"32","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1523\/JNEUROSCI.2089-12.2012","article-title":"An essential role for histone deacetylase 4 in synaptic plasticity and memory formation","volume":"32","author":"Kim","year":"2012","journal-title":"J Neurosci"},{"issue":"11","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"e80849","DOI":"10.1371\/journal.pone.0080849","article-title":"HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo","volume":"8","author":"Mielcarek","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jnr.21521","article-title":"Developmental expression of histone deacetylase 11 in the murine brain","volume":"86","author":"Liu","year":"2008","journal-title":"J Neurosci Res"},{"issue":"16","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"13869","DOI":"10.1074\/jbc.M110.175414","article-title":"Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner","volume":"286","author":"Chen","year":"2011","journal-title":"J Biol Chem"},{"issue":"10","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell Signal"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.phrs.2012.12.009","article-title":"Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury","volume":"70","author":"Crupi","year":"2013","journal-title":"Pharmacol Res"},{"issue":"1-2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2015.04.042","article-title":"Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: possible association with AQP4 modulation","volume":"354","author":"Sadana","year":"2015","journal-title":"J Neurol Sci"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2013.03.001","article-title":"Post-ischaemic thyroid hormone treatment in a rat model of acute stroke","volume":"1513","author":"Genovese","year":"2013","journal-title":"Brain Res"},{"issue":"44","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"38095","DOI":"10.1074\/jbc.M111.257055","article-title":"HDAC4 Protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia","volume":"286","author":"Geng","year":"2011","journal-title":"J Biol Chem"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.celrep.2019.09.023","article-title":"HDAC4 controls muscle homeostasis through deacetylation of myosin heavy chain, PGC-1alpha, and Hsc70","volume":"29","author":"Luo","year":"2019","journal-title":"Cell Rep"},{"issue":"5","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1210\/me.2002-0308","article-title":"Transcriptional activation by thyroid hormone receptor-beta involves chromatin remodeling, histone acetylation, and synergistic stimulation by p300 and steroid receptor coactivators","volume":"17","author":"Lee","year":"2003","journal-title":"Mol Endocrinol"},{"issue":"20","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1093\/emboj\/18.20.5634","article-title":"P300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J"},{"issue":"6595","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/383099a0","article-title":"Role of CBP\/P300 in nuclear receptor signalling","volume":"383","author":"Chakravarti","year":"1996","journal-title":"Nature"},{"issue":"6","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1128\/MCB.20.6.2031-2042.2000","article-title":"P300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin","volume":"20","author":"Li","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"6","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1021\/cr500452k","article-title":"Protein lysine acetylation by p300\/CBP","volume":"115","author":"Dancy","year":"2015","journal-title":"Chem Rev"},{"issue":"21","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1038\/emboj.2010.235","article-title":"CBP\/P300 double null cells reveal effect of coactivator level and diversity on CREB transactivation","volume":"29","author":"Kasper","year":"2010","journal-title":"EMBO J"},{"issue":"7243","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature07861","article-title":"CBP\/p300-mediated acetylation of histone H3 on lysine 56","volume":"459","author":"Das","year":"2009","journal-title":"Nature"},{"issue":"28","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"11493","DOI":"10.1073\/pnas.1309914110","article-title":"Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency","volume":"110","author":"Tan","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1080\/15384101.2015.1106760","article-title":"Cell cycle-dependent changes in H3K56ac in human cells","volume":"14","author":"Stejskal","year":"2015","journal-title":"Cell Cycle"},{"issue":"13","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/emboj.2009.119","article-title":"Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells","volume":"28","author":"Tjeertes","year":"2009","journal-title":"EMBO J"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/s41467-019-12126-4","article-title":"TRIM66 Reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells","volume":"10","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"issue":"11","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.4161\/cc.8.11.8620","article-title":"Histone H3-K56 acetylation is important for genomic stability in mammals","volume":"8","author":"Yuan","year":"2009","journal-title":"Cell Cycle"},{"issue":"11","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1210\/en.2009-0117","article-title":"Residues K128, 132, and 134 in the thyroid hormone receptor-alpha are essential for receptor acetylation and activity","volume":"150","author":"Sanchez-Pacheco","year":"2009","journal-title":"Endocrinology"},{"issue":"3-5","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jsbmb.2010.12.003","article-title":"Acetylation and nuclear receptor action","volume":"123","author":"Wang","year":"2011","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molcel.2006.12.014","article-title":"Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark","volume":"25","author":"Ruthenburg","year":"2007","journal-title":"Mol Cell"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"772000","DOI":"10.3389\/fnmol.2021.772000","article-title":"SETD1A mediated H3K4 methylation and its role in neurodevelopmental and neuropsychiatric disorders","volume":"14(Nov 3)","author":"Wang","year":"2021","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2217\/epi.15.1","article-title":"Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders","volume":"7","author":"Vallianatos","year":"2015","journal-title":"Epigenomics"},{"key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.nlm.2019.04.009","article-title":"Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation","volume":"161(May)","author":"Collins","year":"2019","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2217\/epi.10.12","article-title":"Role of H3K4 demethylases in complex neurodevelopmental diseases","volume":"2","author":"Wynder","year":"2010","journal-title":"Epigenomics"},{"issue":"2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s40495-016-0050-5","article-title":"Oxidative stress under ambient and physiological oxygen tension in tissue culture","volume":"2","author":"Jagannathan","year":"2016","journal-title":"Curr Pharmacol Rep"},{"issue":"2","key":"2023021717293146600_","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/jnr.22765","article-title":"Physiological oxygen level is critical for modeling neuronal metabolism in vitro","volume":"90","author":"Zhu","year":"2012","journal-title":"J Neurosci Res"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvac139\/45809773\/bvac139.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/6\/11\/bvac139\/49246369\/bvac139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/6\/11\/bvac139\/49246369\/bvac139.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T22:09:31Z","timestamp":1676758171000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvac139\/6696601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":84,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,10,11]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvac139","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,1]]},"published":{"date-parts":[[2022,9,13]]},"article-number":"bvac139"}}