{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:41:01Z","timestamp":1777084861206,"version":"3.51.4"},"reference-count":37,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphoma infiltration to the pituitary is rare. It represents less than 0.5% of all reported pituitary metastases (PMs). Here we present a case series of 3 patients with PMs from a systemic lymphoma. Also, we performed a literature review of the cases reported. We identified additional 31 cases in which non-Hodgkin lymphoma (NHL) was the most common (n = 28, 90%), with large B-cell NHL the most frequent histological subtype (n = 14, 45%). Central hypothyroidism (n = 21, 67%) was the most frequent pituitary deficiency followed by adrenal insufficiency (n = 19, 61%) and diabetes insipidus (DI; n = 18, 58%). Full endocrine recovery was found in only 12% (n = 4) of patients after treatment, and magnetic resonance imaging showed tumor regression in 22% of them. In our series, 2 patients were diagnosed with diffuse large B-cell lymphoma, and 1 had mixed cellularity of classic Hodgkin lymphoma. The mean age was 54 \u00b1 6.92\u00a0years. Hypopituitarism and DI were present in all of them, with 100% of mortality because of advanced systemic disease.<\/jats:p>","DOI":"10.1210\/jendso\/bvac161","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:08:38Z","timestamp":1666829318000},"source":"Crossref","is-referenced-by-count":4,"title":["Pituitary Infiltration by Lymphoma"],"prefix":"10.1210","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7583-5537","authenticated-orcid":false,"given":"V\u00edctor Hugo","family":"Tovar-M\u00e9ndez","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , 14080, Mexico City, Tlalpan , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-4667","authenticated-orcid":false,"given":"Dalia","family":"Cuenca","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , 14080, Mexico City, Tlalpan , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7323-0582","authenticated-orcid":false,"given":"Francisco J","family":"G\u00f3mez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , 14080, Mexico City, Tlalpan , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-670X","authenticated-orcid":false,"given":"Daniel","family":"Cuevas-Ramos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , 14080, Mexico City, Tlalpan , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"2022120101331891000_bvac161-B1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jocn.2021.09.016","article-title":"Pituitary metastasis: from pathology to clinical and radiological considerations","volume":"93","author":"Kameda-Smith","year":"2021","journal-title":"J Clin Neurosci"},{"issue":"4","key":"2022120101331891000_bvac161-B2","first-page":"127","article-title":"Pituitary 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