{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:15Z","timestamp":1787021235254,"version":"build-2736575974"},"reference-count":35,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Successful rates of hematopoietic stem cell transplantation (HSCT) face paralleled escalation of late endocrine and metabolic effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to characterize these sequelae distinguishing between the underlying pathologies and treatments received.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective descriptive study was conducted in 157 children post-HSCT (hematopoietic pathology [N = 106], solid tumors [N = 40], and rare entities [N = 11]) followed at a single endocrine department between 2009 and 2019. Regression analysis was used to ascertain association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of all patients, 58.7% presented with at least one endocrine abnormality. Endocrinopathies post HSCT were most frequently developed in lymphoblastic leukemia (60.5% of them), whereas myeloid leukemias had the fewest. A total of 64% of patients presented with primary hypogonadism, 52% short stature, and 20% obesity. Endocrinopathy was associated with older age at HSCT (9.78 years [6.25-12.25] vs 6.78 years [4.06-9.75]) (P &amp;lt; .005), pubertal Tanner stage V (P &amp;lt; .001), chronic graft-vs-host disease (GVHD) (P = .022), and direct gonadal therapy (P = .026). The incidence of endocrinopathies was higher in girls (15% more common; P &amp;lt; .02) and in patients who received radiotherapy (18% higher), steroids (17.4% increase), allogenic HSCT (7% higher), thymoglobulin, or cyclophosphamide. Those on busulfan presented with a 27.5% higher rate of primary hypogonadism (P = .003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than half of children surviving HSCT will develop endocrinopathies. Strikingly, obesity has risen to the third most frequent endocrine disruption, mainly due to steroids, and partly adhering to the general population tendency. Lymphoblastic leukemia was the condition with a higher rate of endocrine abnormalities. Female sex, older age at HSCT, pubertal stage, allogenic transplant, radiotherapy, alkylating drugs, and GVHD pose risk factors for endocrine disturbances.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvac183","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T15:09:46Z","timestamp":1669388986000},"source":"Crossref","is-referenced-by-count":16,"title":["Endocrine Sequelae in 157 Pediatric Survivors of Hematopoietic Stem Cell Transplantation (HSCT)"],"prefix":"10.1210","volume":"7","author":[{"given":"Mar\u00eda","family":"G\u00fcemes","sequence":"first","affiliation":[{"name":"Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , 28009 Madrid , Spain"},{"name":"Research Institute \u201cLa Princesa,\u201d 28009 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Mart\u00edn-Rivada","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , 28009 Madrid , Spain"},{"name":"Research Institute \u201cLa Princesa,\u201d 28009 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bascuas Arribas","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , 28009 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Mar\u00eda","family":"Andr\u00e9s-Esteban","sequence":"additional","affiliation":[{"name":"Department of Statistics, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , 28009 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Molina Angulo","sequence":"additional","affiliation":[{"name":"Department of Hematoncology and Bone Marrow Transplant, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , 28009 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Pozo Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , 28009 Madrid , Spain"},{"name":"Research Institute \u201cLa Princesa,\u201d 28009 Madrid , Spain"},{"name":"Department of Pediatrics, Universidad Aut\u00f3noma de Madrid , 28029 Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u03ccn (CIBEROBN), Instituto de Salud Carlos III , 28029 Madrid , 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