{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:02:08Z","timestamp":1784898128102,"version":"3.55.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>we assessed the diagnostic accuracy of insulin-like growth factor (IGF) 1 measurements with 1 growth hormone stimulation test (GHST) vs performing 2 GHSTs as the standard test to confirm the diagnosis of growth hormone deficiency (GHD) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the baseline characteristics, anthropometric measurements, and laboratory data of 703 children with short stature, aged 4-14 years (mean age, 8.46 \u00b1 2.7 years), who had undergone 2 GHSTs. We compared the diagnostic values of IGF-1 levels by using a cut-off value of \u22640 SD score, along with results of a single clonidine stimulation test (CST). We evaluated the false-positive rate, specificity, likelihood ratio, and area under the curve (AUC) of the 2 diagnostic methods. GHD was diagnosed if the peak growth hormone level was &amp;lt;7\u2005ng\/mL on 2 GHSTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 724 children, 577 (79.7%) had a low IGF-1 level (mean 104.9 \u00b1 61.4\u2005ng\/mL), and 147 (20.3%) had a normal IGF-1 level (mean 145.9 \u00b1 86.9\u2005ng\/mL). GHD was diagnosed in 187 patients (25.8%), of whom 146 (25.3%) had a low IGF-1 level. An IGF-1 level reflecting \u22640 SDs in combination with results of a single CST had a specificity of 92.6%, a false-positive rate of 5.5%, and an AUC of 0.6088. Using an IFG-1 cut-off level of \u2264\u22122 SDs did not alter the diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low IGF-1 values of \u22640 SDs or \u2264\u22122 SDs in combination with results of a single CST had poor diagnostic accuracy for GHD.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jendso\/bvad018","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T17:47:48Z","timestamp":1675187268000},"source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic Value of IGF-1 in Growth Hormone\u2013Deficient Children: Is a Second Growth Hormone Stimulation Test Necessary?"],"prefix":"10.1210","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-7886","authenticated-orcid":false,"given":"Tarah H","family":"Fatani","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Endocrinology, King Abdulaziz University , Jeddah 21589 , Saudi 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