{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:48:28Z","timestamp":1787021308591,"version":"build-2736575974"},"reference-count":100,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["R01 DK110770"],"award-info":[{"award-number":["R01 DK110770"]}]},{"name":"NIH","award":["DK064720"],"award-info":[{"award-number":["DK064720"]}]},{"name":"NIH","award":["UL1 RR024156"],"award-info":[{"award-number":["UL1 RR024156"]}]},{"name":"NIH","award":["UL1 TR000040"],"award-info":[{"award-number":["UL1 TR000040"]}]},{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["P30-DK026687"],"award-info":[{"award-number":["P30-DK026687"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Acromegaly presents a unique pattern of lower adiposity and insulin resistance in active disease but reduction in insulin resistance despite a rise in adiposity after surgery. Depot-specific adipose tissue masses and ectopic lipid are important predictors of insulin resistance in other populations, but whether they are in acromegaly is unknown. Long-term persistence of body composition changes after surgery is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine how depot-specific body composition and ectopic lipid relate to insulin resistance in active acromegaly and whether their changes with surgery are sustained long-term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional study in patients with active acromegaly and longitudinal study in newly diagnosed patients studied before and in long-term follow-up, 3 (1-8) years (median, range), after surgery. Seventy-one patients with active acromegaly studied cross-sectionally and 28 with newly diagnosed acromegaly studied longitudinally. Main outcome measures were visceral (VAT), subcutaneous (SAT), and intermuscular adipose tissue masses by whole-body magnetic resonance imaging; intrahepatic lipid (IHL) by proton magnetic resonance spectroscopy; insulin resistance measures derived from fasting; and oral glucose tolerance test insulin and glucose levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SAT and insulin-like growth factor 1 level, but not VAT or IHL, were independent predictors of insulin resistance in active acromegaly. VAT, SAT, and IHL gains were sustained long-term after surgery. VAT mass rise with surgery correlated inversely with rise in QUICKI while SAT rise correlated with fall in the Homeostatic Model Assessment score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SAT and disease activity are important predictors of insulin resistance in active acromegaly. Adiposity gains are sustained long-term after surgical treatment and impact on the accompanying improvement in insulin resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvad028","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T14:06:30Z","timestamp":1676988390000},"source":"Crossref","is-referenced-by-count":14,"title":["Long-term Outcome of Body Composition, Ectopic Lipid, and Insulin Resistance Changes With Surgical Treatment of Acromegaly"],"prefix":"10.1210","volume":"7","author":[{"given":"Adriana P","family":"Kuker","sequence":"first","affiliation":[{"name":"Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-4923","authenticated-orcid":false,"given":"Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhezhen","family":"Jin","sequence":"additional","affiliation":[{"name":"Biostatistics, Mailman School of Public Health, Columbia University , New York, NY, 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vagelos College of Physicians & Surgeons, Columbia University , New York, NY, 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-0762","authenticated-orcid":false,"given":"Pamela U","family":"Freda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"issue":"Suppl","key":"2023031301555748800_","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1507\/endocrj.43.Suppl_S57","article-title":"Metabolic actions of growth hormone in man","volume":"43","author":"Ho","year":"1996","journal-title":"Endocr J"},{"issue":"1","key":"2023031301555748800_","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ecl.2006.11.005","article-title":"Effects of growth hormone on glucose and fat metabolism in human subjects","volume":"36","author":"Jorgensen","year":"2007","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"11","key":"2023031301555748800_","first-page":"3233","article-title":"Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase","volume":"80","author":"Simsolo","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"3 Pt 1","key":"2023031301555748800_","first-page":"E269","article-title":"Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action","volume":"250","author":"Hansen","year":"1986","journal-title":"Am J Physiol"},{"issue":"5","key":"2023031301555748800_","first-page":"1012","article-title":"Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy","volume":"74","author":"Moller","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023031301555748800_","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1210\/jcem-30-3-288","article-title":"Insulin secretion in acromegaly","volume":"30","author":"Fineberg","year":"1970","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023031301555748800_","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-0029-1210974","article-title":"Decreased peripheral insulin sensitivity in acromegalic patients","volume":"95","author":"Luger","year":"1990","journal-title":"Exp Clin Endocrinol"},{"issue":"5","key":"2023031301555748800_","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/jcem-72-5-1048","article-title":"Peripheral glucose metabolism in acromegaly","volume":"72","author":"Foss","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2023031301555748800_","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/BF00873216","article-title":"Increased glucose turnover and glucose cycling in acromegalic patients with normal glucose tolerance","volume":"29","author":"Karlander","year":"1986","journal-title":"Diabetologia"},{"issue":"8","key":"2023031301555748800_","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2337\/diab.31.8.663","article-title":"Effects of growth hormone on insulin action in man. 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