{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:22:15Z","timestamp":1783488135904,"version":"3.55.0"},"reference-count":26,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypoparathyroidism (HypoPT) is a rare disease associated with high morbidity. Its economic impact is not well understood. This retrospective, cross-sectional study used data from the United States-based National Inpatient Sample and the Nationwide Emergency Department Sample from 2010 to 2018 to quantify overall trends in number, cost, charges, and length of stay (LOS) for inpatient hospitalizations and number and charges for emergency department (ED) visits for HypoPT-related and for non-HypoPT-related causes. Additionally, the study estimated the marginal effect of HypoPT on total inpatient hospitalization costs and LOS as well as ED visit charges. Over the observed period, a mean of 56.8\u201366.6 HypoPT-related hospitalizations and 14.6\u201319.5 HypoPT-related ED visits were recorded per 100 000 visits per year. Over this period, the rate of HypoPT-related inpatient hospitalizations and ED visits increased by 13.5% and 33.6%, respectively. The mean LOS for HypoPT-related hospitalizations was consistently higher than for non-HypoPT-related causes. Total annual HypoPT-related inpatient hospitalization costs increased by 33.6%, and ED visit charges increased by 96.3%. During the same period, the annual costs for non-HypoPT-related hospitalizations and charges for ED visits increased by 5.2% and 80.3%, respectively. In all years, HypoPT-related hospital encounters resulted in higher charges and costs per individual visit than non-HypoPT-related encounters. The marginal effect of HypoPT on inpatient hospitalization costs and LOS, and on ED charges, increased over the period of observation. This study demonstrated that HypoPT was associated with substantial and increasing healthcare utilization in the United States between 2010 and 2018.<\/jats:p>","DOI":"10.1210\/jendso\/bvad050","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T09:59:03Z","timestamp":1681811943000},"source":"Crossref","is-referenced-by-count":5,"title":["Recent Trends in Hypoparathyroidism-Related Inpatient and Emergency Department Admissions and Costs in the United States"],"prefix":"10.1210","volume":"7","author":[{"given":"Sanjiv","family":"Kaul","sequence":"first","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health & Science University , Portland, OR 97239 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira O","family":"Gosmanova","sequence":"additional","affiliation":[{"name":"Albany Medical College , Albany, NY 12208 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Castriota","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals U.S.A., Inc. , Cambridge, MA 02139 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Hitchens","sequence":"additional","affiliation":[{"name":"RTI Health Solutions , Research Triangle Park, NC 27709 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Candrilli","sequence":"additional","affiliation":[{"name":"RTI Health Solutions , Research Triangle Park, NC 27709 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Parikh","sequence":"additional","affiliation":[{"name":"RTI Health Solutions , Research Triangle Park, NC 27709 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Esterberg","sequence":"additional","affiliation":[{"name":"RTI Health Solutions , Research Triangle Park, NC 27709 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-5900","authenticated-orcid":false,"given":"Olulade","family":"Ayodele","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals U.S.A., Inc. , Lexington, MA 02420 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"issue":"6","key":"2023050410472723000_bvad050-B1","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1210\/jc.2015-3908","article-title":"Epidemiology and diagnosis of hypoparathyroidism","volume":"101","author":"Clarke","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2023050410472723000_bvad050-B2","author":"Clarke","year":"2011"},{"issue":"10","key":"2023050410472723000_bvad050-B3","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research","volume":"26","author":"Bilezikian","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2023050410472723000_bvad050-B4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. 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