{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:08:33Z","timestamp":1785798513660,"version":"3.56.0"},"reference-count":28,"publisher":"The Endocrine Society","issue":"5","funder":[{"name":"National Institute of Diabetes"},{"name":"and Digestive and Kidney Diseases","award":["DK043006-46"],"award-info":[{"award-number":["DK043006-46"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Autologous implantation of parathyroid tissue is frequently utilized after parathyroidectomy in patients with heritable forms of primary hyperparathyroidism (PHPT). Data on long-term functional outcome of these grafts is sparse.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate long-term outcomes of parathyroid autografts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective study of patients with PHPT who underwent parathyroid autografts from 1991 to 2020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 115 patients with PHPT who underwent 135 parathyroid autografts. Median follow-up duration since graft was 10 (4-20) years. Of the 111 grafts with known functional outcome, 54 (49%) were fully functional, 13 (12%) partially functional, and 44 (40%) nonfunctional at last follow-up. Age at time of graft, thymectomy prior to autograft, graft type (delayed vs immediate), or duration of cryopreservation did not predict functional outcome. There were 45 (83%) post-graft PHPT recurrences among 54 fully functional grafts at a median duration of 8 (4-15) years after grafting. Surgery was performed in 42\/45 recurrences, but cure was attained in 18\/42 (43%) only. Twelve of 18 (67%) recurrences were graft-related while remaining 6 (33%) had a neck or mediastinal source. Median time to recurrence was 16 (11-25) years in neck or mediastinal source vs 7 (2-13) years in graft-related recurrences. Median parathyroid hormone (PTH) gradient was significantly higher at 23 (20-27) in graft-related recurrence vs 1.3 (1.2-2.5) in neck or mediastinal source (P = .03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Post-graft recurrence of PHPT occurs frequently within the first decade after graft and is challenging to localize. Time to recurrence after graft is significantly shorter and PTH gradient higher for graft-related recurrence.<\/jats:p>\n                  <jats:p>Clinical Trial Number: NCT04969926<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvad055","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T20:37:36Z","timestamp":1682195856000},"source":"Crossref","is-referenced-by-count":4,"title":["Long-Term Outcomes of Parathyroid Autografts in Primary Hyperparathyroidism"],"prefix":"10.1210","volume":"7","author":[{"given":"Elias","family":"Chuki","sequence":"first","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akua","family":"Graf","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Ninan","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Tora","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomilowo","family":"Abijo","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Bliss","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naris","family":"Nilubol","sequence":"additional","affiliation":[{"name":"National Cancer Institute, National Institutes of Health , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita K","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-706X","authenticated-orcid":false,"given":"William F","family":"Simonds","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-3340","authenticated-orcid":false,"given":"Smita","family":"Jha","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,4,22]]},"reference":[{"issue":"4","key":"2023050306111713700_bvad055-B1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00000658-190710000-00001","article-title":"I. The parathyroid glandules. Their blood supply and their preservation in operation upon the thyroid gland","volume":"46","author":"Halsted","year":"1907","journal-title":"Ann Surg"},{"issue":"1","key":"2023050306111713700_bvad055-B2","first-page":"34","article-title":"Transplantation of the parathyroid glands in man: clinical indications and results","volume":"78","author":"Wells SA","year":"1975","journal-title":"Surgery"},{"issue":"3","key":"2023050306111713700_bvad055-B3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1067\/msy.2000.107102","article-title":"Parathyroid-induced angiogenesis is VEGF-dependent","volume":"128","author":"Carter","year":"2000","journal-title":"Surgery"},{"issue":"7","key":"2023050306111713700_bvad055-B4","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1245\/s10434-013-2941-6","article-title":"Parathyroid cryopreservation after parathyroidectomy: a worthwhile practice?","volume":"20","author":"Shepet","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"2023050306111713700_bvad055-B5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.surg.2009.10.010","article-title":"Results of cryopreserved parathyroid autografts: a retrospective multicenter study","volume":"147","author":"Borot","year":"2010","journal-title":"Surgery"},{"issue":"5","key":"2023050306111713700_bvad055-B6","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s00268-007-9437-0","article-title":"Viability of cryopreserved parathyroid tissue: when is continued storage versus disposal indicated?","volume":"32","author":"Guerrero","year":"2008","journal-title":"World J Surg"},{"issue":"6","key":"2023050306111713700_bvad055-B7","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.surg.2005.09.029","article-title":"Long-term functionality of cryopreserved parathyroid autografts: a 13-year prospective analysis","volume":"138","author":"Cohen","year":"2005","journal-title":"Surgery"},{"issue":"1","key":"2023050306111713700_bvad055-B8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1210\/jcem-70-1-149","article-title":"Circulating fibroblast growth factor-like substance in familial multiple endocrine neoplasia type 1","volume":"70","author":"Zimering","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2023050306111713700_bvad055-B9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1210\/jcem-48-4-648","article-title":"Human parathyroid autografts: comparison of function in vivo and in vitro","volume":"48","author":"Brown","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2023050306111713700_bvad055-B10","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00268-009-0057-8","article-title":"Dynamics of parathyroid hormone secretion after total parathyroidectomy and autotransplantation","volume":"33","author":"Conti-Freitas","year":"2009","journal-title":"World J Surg"},{"issue":"6","key":"2023050306111713700_bvad055-B11","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1067\/msy.2099.101580","article-title":"Results of heterotopic parathyroid autotransplantation: a 13-year experience","volume":"126","author":"Feldman","year":"1999","journal-title":"Surgery"},{"issue":"19","key":"2023050306111713700_bvad055-B12","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1056\/NEJM197811092991909","article-title":"Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma","volume":"299","author":"Brennan","year":"1978","journal-title":"N Engl J Med"},{"issue":"11","key":"2023050306111713700_bvad055-B13","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/hed.25371","article-title":"Predictors of graft function after parathyroid autotransplantation during thyroid surgery","volume":"40","author":"Zhang","year":"2018","journal-title":"Head Neck"},{"issue":"4","key":"2023050306111713700_bvad055-B14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF02988528","article-title":"Tc-99m-MIBI scintigraphy for recurrent hyperparathyroidism after total parathyroidectomy with autograft","volume":"17","author":"Itoh","year":"2003","journal-title":"Ann Nucl Med"},{"key":"2023050306111713700_bvad055-B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"issue":"2","key":"2023050306111713700_bvad055-B16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"issue":"6","key":"2023050306111713700_bvad055-B17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4158\/EP-2018-0547","article-title":"Cryopreservation of parathyroid tissue: a white paper on establishing a local service","volume":"25","author":"Moore","year":"2019","journal-title":"Endocr Pract"},{"issue":"12","key":"2023050306111713700_bvad055-B18","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/archsurg.136.12.1381","article-title":"Parathyroid autotransplantation during thyroidectomy: documentation of graft function","volume":"136","author":"Lo","year":"2001","journal-title":"Arch Surg"},{"issue":"Suppl 1","key":"2023050306111713700_bvad055-B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00031305.2019.1583913","article-title":"Moving to a world beyond \u201cP &lt; .05.\u201d","volume":"73","author":"Wasserstein","year":"2019","journal-title":"Am Stat"},{"issue":"Suppl 1","key":"2023050306111713700_bvad055-B20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.6061\/clinics\/2012(Sup01)22","article-title":"Total parathyroidectomy in a large cohort of cases with hyperparathyroidism associated with multiple endocrine neoplasia type 1: experience from a single academic center","volume":"67","author":"Montenegro","year":"2012","journal-title":"Clinics (Sao Paulo)"},{"issue":"6","key":"2023050306111713700_bvad055-B21","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1007\/s00268-012-1451-1","article-title":"Preoperative localizing studies for initial parathyroidectomy in MEN1 syndrome: is there any benefit?","volume":"36","author":"Nilubol","year":"2012","journal-title":"World J Surg"},{"issue":"5","key":"2023050306111713700_bvad055-B22","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1046\/j.1445-2197.2003.t01-1-02620.x","article-title":"Embryonic parathyroid rests occur commonly and have implications in the management of secondary hyperparathyroidism","volume":"73","author":"Aly","year":"2003","journal-title":"ANZ J Surg"},{"issue":"6","key":"2023050306111713700_bvad055-B23","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.surg.2008.08.031","article-title":"The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism","volume":"144","author":"Powell","year":"2008","journal-title":"Surgery"},{"issue":"5","key":"2023050306111713700_bvad055-B24","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.surg.2021.10.046","article-title":"Evaluation of risk factors, long-term outcomes, and immediate and delayed autotransplantation to minimize postsurgical hypoparathyroidism in multiple endocrine neoplasia type 1 (MEN1): a retrospective cohort study","volume":"171","author":"Landry","year":"2022","journal-title":"Surgery"},{"issue":"5","key":"2023050306111713700_bvad055-B25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1089\/bio.2018.0140","article-title":"Parathyroid tissue cryopreservation: does the storage time affect viability and functionality?","volume":"17","author":"Aiti","year":"2019","journal-title":"Biopreserv Biobank"},{"issue":"4","key":"2023050306111713700_bvad055-B26","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/BF01675660","article-title":"Secondary hyperparathyroidism: diagnosis of site of recurrence","volume":"15","author":"Casanova","year":"1991","journal-title":"World J Surg"},{"issue":"6","key":"2023050306111713700_bvad055-B27","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00268-004-7321-8","article-title":"Assessing the site of recurrence in patients with secondary hyperparathyroidism by a simplified Casanova autograftectomy test","volume":"28","author":"Schlosser","year":"2004","journal-title":"World J Surg"},{"issue":"1","key":"2023050306111713700_bvad055-B28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/00365519609088587","article-title":"Five to 10 years follow-up after total parathyroidectomy and autotransplantation of parathyroid tissue: evaluation of parathyroid function by use of ischaemic blockade manoeuvre","volume":"56","author":"Knudsen","year":"1996","journal-title":"Scand J Clin Lab Invest"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvad055\/50066853\/bvad055.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/7\/5\/bvad055\/50171402\/bvad055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/7\/5\/bvad055\/50171402\/bvad055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:11:56Z","timestamp":1683094316000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvad055\/7136672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,3,6]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvad055","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,3,6]]},"article-number":"bvad055"}}