{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:54:30Z","timestamp":1793732070294,"version":"4.6.1"},"reference-count":56,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Since the COVID-19 outbreak, the number of girls with suspected precocious puberty has increased.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the incidence of idiopathic central precocious puberty (ICPP) during COVID-19 with that of the previous 4 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Anthropometric, biochemical, and radiological parameters were collected between January 2016 and June 2021 from 133 girls who met the Rapidly Progressive ICPP criteria (RP-ICPP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found a higher incidence of RP-ICPP between March 2020 and June 2021 (group 2) compared with January 2016 through March 2020 (group 1) (53.5% vs 41.1%); 2021 showed the highest annual incidence (P &amp;lt; .05). Group 1 and group 2 differed in age at diagnosis (7.96 \u00b1 0.71 vs 7.61 \u00b1 0.94; P &amp;lt; .05), mean Tanner stage (2.86 \u00b1 0.51 vs 2.64 \u00b1 0; P &amp;lt; .05), and in the time between the appearance of thelarche and diagnosis (0.93 \u00b1 0.75 vs 0.71 \u00b1 0.62 years, P &amp;lt; .05). There was an increase in the number of girls aged &amp;lt;8 years in group 2 and a significantly higher number of girls aged &amp;gt;8 years was found in group 1 (42 in group 1 vs 20 in group 2, P &amp;lt; 0.05). Overall body mass index SD score showed higher values \u200b\u200bin group 2 (1.01 \u00b1 1.23 vs 0.69 \u00b1 1.15; P = .18), which spent an average of 1.94 \u00b1 1.81\u2005hours per day using electronic devices; 88.5% of this group stopped any physical activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A spike in new diagnoses of idiopathic (1.79-fold higher) and RP-CPP coincided with the COVID-19 pandemic. The incidence of RP-ICPP was 1.3-fold higher during COVID-19 with a trend toward an increase in body mass index SD score. The expanding use of digital devices and the reduction of daily physical activity represent possible risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvad094","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T18:56:32Z","timestamp":1691088992000},"source":"Crossref","is-referenced-by-count":17,"title":["Precocious Puberty Diagnoses Spike, COVID-19 Pandemic, and Body Mass Index: Findings From a 4-year Study"],"prefix":"10.1210","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-6501","authenticated-orcid":false,"given":"Daniela","family":"Fava","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , 16132 Genoa , Italy"},{"name":"Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini , 16147 Genoa , 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Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Pepe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , 16132 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Paoloni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , 16132 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Francesca","family":"Strati","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , 16132 Genoa , 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Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , 16132 Genoa , Italy"},{"name":"Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini , 16147 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-4548","authenticated-orcid":false,"given":"Emilio","family":"Casalini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , 16132 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-1079","authenticated-orcid":false,"given":"Marta","family":"Bassi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , 16132 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-9299","authenticated-orcid":false,"given":"Maria Grazia","family":"Calevo","sequence":"additional","affiliation":[{"name":"Scientific Direction, Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini , 16147 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3567-6118","authenticated-orcid":false,"given":"Flavia","family":"Napoli","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini , 16147 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-5238","authenticated-orcid":false,"given":"Mohamad","family":"Maghnie","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of 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