{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:55:25Z","timestamp":1784238925488,"version":"3.55.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["JP23K15169"],"award-info":[{"award-number":["JP23K15169"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>GH supplementation for GH deficiency (GHD) has been reported to decrease high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker; however, the association between GHD and hs-CRP remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to clarify the impact of impaired GH secretion due to pituitary masses on hs-CRP levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively examined the association between GH secretion, assessed using GH-releasing peptide-2, and serum hs-CRP levels before and a year after the pituitary surgery in patients with nonfunctioning pituitary neuroendocrine tumor or Rathke cleft cyst.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 171 patients, 55 (32%) presented with severe GHD (peak GH response to GH-releasing peptide-2 &amp;lt; 9\u2005ng\/mL). Serum hs-CRP levels were significantly higher in patients with severe GHD than in those without (P &amp;lt; .001) and significantly correlated with the peak GH (r = \u22120.50, P &amp;lt; .001). Multiple regression analyses showed that the peak GH significantly and negatively predicted hs-CRP levels (\u03b2 = \u22120.345; 95% CI, \u22120.533 to \u22120.158) and the lowest quartile of the peak GH (&amp;lt;5.04\u2005ng\/mL) were significantly associated with increase in hs-CRP levels (exp [\u03b2] = 1.840; 95% CI, 1.209 to 2.801), after controlling for other anterior hormones and metabolic parameters. Postoperative change in the peak GH (N = 60) significantly predicted change in hs-CRP levels (\u03b2 = \u22120.391; 95% CI, \u22120.675 to \u22120.108), independent of alterations in other anterior hormones and metabolic parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The inverse association between GH secretion and hs-CRP levels highlights the protective role of GH in the increase in hs-CRP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvad137","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T06:34:13Z","timestamp":1699425253000},"source":"Crossref","is-referenced-by-count":5,"title":["Effect of GH Deficiency Caused by Nonfunctioning Pituitary Masses on Serum C-reactive Protein Levels"],"prefix":"10.1210","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-7704","authenticated-orcid":false,"given":"Yasufumi","family":"Seki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tokyo Women's Medical University , Tokyo, 162-8666 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-2319","authenticated-orcid":false,"given":"Satoshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Women's Medical University , Tokyo, 162-8666 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-8406","authenticated-orcid":false,"given":"Kanako","family":"Bokuda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Women's Medical University , Tokyo, 162-8666 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-829X","authenticated-orcid":false,"given":"Daisuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Women's Medical University , Tokyo, 162-8666 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-8275","authenticated-orcid":false,"given":"Kaoru","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Women's Medical University , Tokyo, 162-8666 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Women's Medical University , Tokyo, 162-8666 , 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