{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:56Z","timestamp":1753883576181,"version":"3.41.2"},"reference-count":28,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T00:00:00Z","timestamp":1700352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin D deficiency is a global public health concern that provokes bone demineralization and weakening. In response to the decreased vitamin D level, calcium stores wear out. The homeostatic effect of compensatory hyperparathyroidism in vitamin D deficiency incites variable discrepancies in different populations. This study intends to decipher the transition point of PTH in relation to levels of vitamin D in a Nepalese population. A cross-sectional study was carried out at Tribhuvan University Teaching Hospital, Nepal. Serum calcium, phosphorus, intact PTH, and 25-hydroxy vitamin D levels were assayed in an Abbott ARCHITECT Integrated System. A correlation plot of PTH and vitamin D was analyzed in Statistical Package for Social Sciences version 22.0. Using a locally weighted scatter plot smoothing method, the relation between these variables was presented graphically. Among 281 individuals, 30.2% had vitamin D levels below 20\u2005ng\/mL. There was an archetypical transition in the PTH levels in concert with the decrease in vitamin D level marked by 2 inflection points (ie, 18.5 and 42.0\u2005ng\/mL). Our findings suggest that to augment overall health and avert weakness due to vitamin D deficiency, the levels of vitamin D should be maintained above 42.0\u2005ng\/mL in our population.<\/jats:p>","DOI":"10.1210\/jendso\/bvad143","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T14:31:58Z","timestamp":1700145118000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of Low Vitamin D and Intact Parathyroid Hormone (iPTH) in Nepalese Population: When Does iPTH Exactly Rise?"],"prefix":"10.1210","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-7459","authenticated-orcid":false,"given":"Sujata","family":"Baidya","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-3953","authenticated-orcid":false,"given":"Eans Tara","family":"Tuladhar","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9092-4957","authenticated-orcid":false,"given":"Vijay Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-2524","authenticated-orcid":false,"given":"Raju Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithileshwer","family":"Raut","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-0629","authenticated-orcid":false,"given":"Aseem","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naresh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Endocrinology), Institute of Medicine, Tribhuvan University Teaching Hospital , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-7969","authenticated-orcid":false,"given":"Apeksha","family":"Niraula","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University , Kathmandu 44600 , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"issue":"3","key":"2024030812593119400_bvad143-B1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"2024030812593119400_bvad143-B2","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.2215\/CJN.05910809","article-title":"Calcium metabolism in health and 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