{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:11:11Z","timestamp":1767337871562,"version":"3.41.2"},"reference-count":64,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"NIH Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000124","name":"ORWH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The association between women's stress and pregnancy glucose levels remain unclear, specifically when considering the preconception period as a sensitive window of exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We investigated whether preconception perceived stress was associated with glucose levels during pregnancy among women attending a fertility center (2004-2019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Before conception, women completed a psychological stress survey using the short version of the validated Perceived Stress Scale 4 (PSS-4), and blood glucose was measured using a 50-gram glucose load test during late pregnancy as a part of screening for gestational diabetes. Linear and log-binomial regression models were used to assess associations of total PSS-4 scores with mean glucose levels and abnormal glucose levels ( \u2265 140\u2005mg\/dL), adjusting for age, body mass index, race, smoking, education, physical activity, primary infertility diagnosis, number of babies, and mode of conception.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Psychological stress was positively associated with mean abnormal glucose levels. The adjusted marginal means (95% CI) of mean glucose levels for women in the first, second, and third tertiles of psychological stress were 115 (110, 119), 119 (115, 123), and 124 (119, 128), and mg\/dL, respectively (P for trend = .007). Also, women in the second and third tertiles of psychological stress had 4% and 13% higher probabilities of having abnormal glucose compared with women in the first tertile of psychological stress (P trend = .01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These results highlight the importance of considering preconception when evaluating the relationship between women's stress and pregnancy glucose levels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvad152","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T18:00:52Z","timestamp":1704391252000},"source":"Crossref","is-referenced-by-count":1,"title":["Preconception Stress and Pregnancy Serum Glucose Levels Among Women Attending a Fertility Center"],"prefix":"10.1210","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-3900","authenticated-orcid":false,"given":"Lidia","family":"M\u00ednguez-Alarc\u00f3n","sequence":"first","affiliation":[{"name":"Channing Division of Network Medicine, Harvard Medical School & Brigham and Women's Hospital , Boston 02115 , USA"},{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Chagnon","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige L","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"},{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-5169","authenticated-orcid":false,"given":"Tamarra","family":"James-Todd","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer B","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Souter","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine and IVF, Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn M","family":"Rexrode","sequence":"additional","affiliation":[{"name":"Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russ","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge E","family":"Chavarro","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Harvard Medical School & Brigham and Women's Hospital , Boston 02115 , USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston 02115 , USA"},{"name":"Department of Nutrition, Harvard T.H. 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