{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:54:50Z","timestamp":1787630090006,"version":"build-2736575974"},"reference-count":34,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Endocrine Society\u20142021 Research Experience for Graduate"},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is a heterogenous clinical syndrome defined by hyperandrogenism and irregular menses. In adult women with PCOS, discrete metabolic and reproductive subgroups have been identified. We hypothesize that distinct phenotypes can be distinguished between adolescent girls who are lean (LN-G) and girls with obesity (OB-G) at the time of PCOS diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were extracted from the CALICO multisite PCOS database. Clinical data collected at the time of diagnosis were available in 354 patients (81% with obesity) from 7 academic centers. Patients with body mass index (BMI) &amp;lt; 85th percentile for age and sex were characterized as lean (LN-G) and those with BMI percentile \u2265 95th percentile as obese (OB-G). We compared metabolic and reproductive phenotypes in LN-G and OB-G.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Reproductive phenotypes differed between the groups, with LN-G having higher total testosterone, androstenedione, and LH levels, while OB-G had lower sex hormone binding globulin (SHBG) and higher free testosterone. Metabolic profiles differed as expected, with OB-G having higher hemoglobin A1c, alanine aminotransferase, and serum triglycerides and more severe acanthosis nigricans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LN-G with PCOS had a distinct reproductive phenotype characterized by increased LH, total testosterone, and androstenedione levels, suggesting neuroendocrine-mediated ovarian androgen production. In contrast, phenotypes in OB-G suggest hyperandrogenemia is primarily driven by insulin resistance with low SHBG levels. These observations support the existence of distinct metabolic and reproductive subtypes in adolescent PCOS characterized by unique mechanisms for hyperandrogenemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvad169","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:29:46Z","timestamp":1704853786000},"source":"Crossref","is-referenced-by-count":20,"title":["Distinct Reproductive Phenotypes Segregate With Differences in Body Weight in Adolescent Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"8","author":[{"given":"Angie","family":"Chen-Patterson","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Bernier","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, University of Florida , Gainesville, FL 32608 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Burgert","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Children's Mercy Hospital , Kansas City, MO 64108 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Davis","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, John H. Stroger, Jr. Hospital , Chicago, IL 60612 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tazeena","family":"Khan","sequence":"additional","affiliation":[{"name":"University of Illinois College of Medicine , Chicago, IL 60612 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Geller","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Children's Hospital , Los Angeles, CA 90027 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Paprocki","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Children's Mercy Hospital , Kansas City, MO 64108 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma F","family":"Witchel","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, University of Pittsburgh, UPMC Children's Hospital of Pittsburgh , Pittsburgh, PA 15224 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Pereira-Eshraghi","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Columbia University , NewYork, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1049-031X","authenticated-orcid":false,"given":"Aviva B","family":"Sopher","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Columbia University , NewYork, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie G","family":"Cree","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, University of Colorado Anschutz , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2468-7137","authenticated-orcid":false,"given":"Laura C","family":"Torchen","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Lurie Children's Hospital, Northwestern University , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"issue":"10","key":"2024011115532718600_bvad169-B1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1210\/clinem\/dgad463","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"108","author":"Teede","year":"2023","journal-title":"J Clin Endocrinol Metabol"},{"issue":"5","key":"2024011115532718600_bvad169-B2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"issue":"10","key":"2024011115532718600_bvad169-B3","first-page":"2966","article-title":"Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism","volume":"80","author":"Apter","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2024011115532718600_bvad169-B4","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024011115532718600_bvad169-B5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"key":"2024011115532718600_bvad169-B6","first-page":"377","volume-title":"Polycystic Ovary Syndrome","author":"Zawadzki","year":"1992"},{"issue":"9","key":"2024011115532718600_bvad169-B7","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum Reprod"},{"issue":"1","key":"2024011115532718600_bvad169-B8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil Steril"},{"issue":"10","key":"2024011115532718600_bvad169-B9","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.3390\/diagnostics12102313","article-title":"Comparing lean and obese PCOS in different PCOS phenotypes: evidence that the body weight is more important than the rotterdam phenotype in influencing the metabolic Status","volume":"12","author":"Carmina","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"11","key":"2024011115532718600_bvad169-B10","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1038\/oby.2010.58","article-title":"Hyperandrogenemia in obese peripubertal girls: correlates and potential etiological determinants","volume":"18","author":"Knudsen","year":"2010","journal-title":"Obesity (Silver Spring, Md)"},{"issue":"2","key":"2024011115532718600_bvad169-B11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1210\/jc.2006-2002","article-title":"Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls","volume":"92","author":"McCartney","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2024011115532718600_bvad169-B12","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.ijo.0801994","article-title":"Obesity and the polycystic ovary syndrome","volume":"26","author":"Gambineri","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"6","key":"2024011115532718600_bvad169-B13","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/humrep\/16.6.1255","article-title":"Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome","volume":"16","author":"Kirchengast","year":"2001","journal-title":"Hum Reprod"},{"issue":"9","key":"2024011115532718600_bvad169-B14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diab.38.9.1165","article-title":"Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome","volume":"38","author":"Dunaif","year":"1989","journal-title":"Diabetes"},{"issue":"1","key":"2024011115532718600_bvad169-B15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0015-0282(99)00203-4","article-title":"Bone mineral density and body composition in lean women with polycystic ovary syndrome","volume":"72","author":"Good","year":"1999","journal-title":"Fertil Steril"},{"issue":"3","key":"2024011115532718600_bvad169-B16","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1210\/jc.2007-2117","article-title":"Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome","volume":"93","author":"Barber","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024011115532718600_bvad169-B17","first-page":"1052","article-title":"Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance","volume":"78","author":"Holte","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024011115532718600_bvad169-B18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/pedi.13206","article-title":"Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity","volume":"22","author":"Hudnut-Beumler","year":"2021","journal-title":"Pediatr Diabetes"},{"issue":"3","key":"2024011115532718600_bvad169-B19","doi-asserted-by":"crossref","first-page":"e29-e","DOI":"10.1542\/peds.102.3.e29","article-title":"Obesity evaluation and treatment: expert committee recommendations","volume":"102","author":"Barlow","year":"1998","journal-title":"Pediatrics"},{"issue":"6","key":"2024011115532718600_bvad169-B20","doi-asserted-by":"crossref","first-page":"e1003132","DOI":"10.1371\/journal.pmed.1003132","article-title":"Distinct subtypes of polycystic ovary syndrome with novel genetic associations: an unsupervised, phenotypic clustering analysis","volume":"17","author":"Dapas","year":"2020","journal-title":"PLoS Med"},{"issue":"10","key":"2024011115532718600_bvad169-B21","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1093\/humrep\/des232","article-title":"Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria","volume":"27","author":"Yildiz","year":"2012","journal-title":"Hum Reprod"},{"issue":"5","key":"2024011115532718600_bvad169-B22","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.fertnstert.2007.01.032","article-title":"Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria","volume":"88","author":"Shroff","year":"2007","journal-title":"Fertil Steril"},{"issue":"2","key":"2024011115532718600_bvad169-B23","doi-asserted-by":"crossref","first-page":"e1003679","DOI":"10.1371\/journal.pmed.1003679","article-title":"Obesity and risk of female reproductive conditions: a Mendelian randomisation study","volume":"19","author":"Venkatesh","year":"2022","journal-title":"PLoS Med"},{"issue":"6","key":"2024011115532718600_bvad169-B24","doi-asserted-by":"crossref","first-page":"dgaa125","DOI":"10.1210\/clinem\/dgaa125","article-title":"Body mass Index and polycystic ovary syndrome: a 2-sample bidirectional Mendelian randomization study","volume":"105","author":"Zhao","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024011115532718600_bvad169-B25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng.732","article-title":"Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3","volume":"43","author":"Chen","year":"2011","journal-title":"Nat Genet"},{"issue":"12","key":"2024011115532718600_bvad169-B26","doi-asserted-by":"crossref","first-page":"e1007813","DOI":"10.1371\/journal.pgen.1007813","article-title":"Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria","volume":"14","author":"Day","year":"2018","journal-title":"PLoS Genet"},{"key":"2024011115532718600_bvad169-B27","doi-asserted-by":"crossref","first-page":"8464","DOI":"10.1038\/ncomms9464","article-title":"Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome","volume":"6","author":"Day","year":"2015","journal-title":"Nat Commun"},{"key":"2024011115532718600_bvad169-B28","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1038\/ncomms8502","article-title":"Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations","volume":"6","author":"Hayes","year":"2015","journal-title":"Nat Commun"},{"issue":"10","key":"2024011115532718600_bvad169-B29","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1210\/jc.2003-030617","article-title":"Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents","volume":"88","author":"Silfen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2024011115532718600_bvad169-B30","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","article-title":"Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome","volume":"44","author":"Shi","year":"2012","journal-title":"Nat Genet"},{"issue":"1","key":"2024011115532718600_bvad169-B31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0015-0282(97)81873-0","article-title":"Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood","volume":"67","author":"Dumesic","year":"1997","journal-title":"Fertil Steril"},{"issue":"6","key":"2024011115532718600_bvad169-B32","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41591-018-0035-5","article-title":"Elevated prenatal anti-Mullerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood","volume":"24","author":"Tata","year":"2018","journal-title":"Nat Med"},{"issue":"2","key":"2024011115532718600_bvad169-B33","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1002\/cphy.c210025","article-title":"Polycystic ovary syndrome and the neuroendocrine consequences of androgen excess","volume":"12","author":"Silva","year":"2022","journal-title":"Compr Physiol"},{"key":"2024011115532718600_bvad169-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000494899","article-title":"In utero androgen excess: a developmental commonality preceding polycystic ovary syndrome?","volume":"53","author":"Abbott","year":"2019","journal-title":"Front Horm Res"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvad169\/55284899\/bvad169.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/8\/2\/bvad169\/55444286\/bvad169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/8\/2\/bvad169\/55444286\/bvad169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T15:53:55Z","timestamp":1704988435000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvad169\/7513662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,5]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,5]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvad169","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,5]]},"article-number":"bvad169"}}