{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:11:00Z","timestamp":1768680660000,"version":"3.49.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hospital Clinica Nova"},{"DOI":"10.13039\/501100020042","name":"Universidad de Monterrey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Hypothyroidism is conventionally treated with replacement therapy through levothyroxine (LT4). Despite the improvement in symptoms, cold intolerance persists in some patients. The present study aims to determine whether there is a difference in temperature perception and skin temperature between patients with primary controlled hypothyroidism (PCH) and a group of healthy controls matched for body mass index and age. Secondarily we aimed to determine difference in quality of life.<\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n Skin temperature measurements were performed in both groups, both in the central and peripheral regions of the body. In addition, subjects were asked about their perception of temperature in a temperature-controlled room; anthropometric measurements were taken, their quality of life was assessed using the ThyPRO-39, and a thyroid hormone profile was performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Eleven patients in the PCH group and 30 patients in the control group were studied. It was found that the group with PCH presented a significantly lower palmar temperature than the control group [mean (SD) of 32.05 (1.79) vs 33.10 (1.30) oC, P = .046]. A mediation model showed a direct effect. Temperature perception was equal between groups. The median (interquartile range) of ThyPRO was 8 (5.2) points in the control group vs 21.8 (13.5) in the group of controlled hypothyroidism, P &lt; .001.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n These results suggest that, despite LT4 treatment, patients continue to present abnormalities in thermogenesis-related thermogenesis, and this may be due to a lack of hormonal adaptation to environmental changes and physiological demands, leading to lower body temperatures and increased sensitivity to cold.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/jendso\/bvad175","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:59:42Z","timestamp":1704070782000},"source":"Crossref","is-referenced-by-count":5,"title":["Temperature Differences Between Controlled Primary Hypothyroidism and Healthy Patients: An Exploratory 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Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rivera-Cavazos","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Vicerrector\u00eda de Ciencias de la Salud, Universidad de Monterrey , 66238 San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n , Mexico"},{"name":"Research Department, Hospital Cl\u00ednica Nova de Monterrey , 66450 San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devany Paola","family":"Morales-Rodriguez","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Vicerrector\u00eda de Ciencias de la Salud, Universidad de Monterrey , 66238 San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n , Mexico"},{"name":"Research Department, Hospital Cl\u00ednica Nova de Monterrey , 66450 San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Israel","family":"Gonz\u00e1lez-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Research Department, Hospital Cl\u00ednica Nova de Monterrey , 66450 San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene Antonieta","family":"Barco-Flores","sequence":"additional","affiliation":[{"name":"Research Department, Hospital Cl\u00ednica Nova de Monterrey , 66450 San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Manilla-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Vicerrector\u00eda de Ciencias de la Salud, Universidad de Monterrey , 66238 San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Villarreal-Leal","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Vicerrector\u00eda de Ciencias de 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