{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T03:04:22Z","timestamp":1771815862423,"version":"3.50.1"},"reference-count":49,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MGH FLS"},{"name":"Department of Orthopedics"},{"DOI":"10.13039\/100019688","name":"Department of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019688","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MGH Care Redesign Initiative program"},{"name":"Clinical Impact Research Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Addressing vitamin D deficiency (VDD) is important for fracture secondary prevention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To explore the function of a fracture liaison service (FLS) to address VDD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Setting and Patients<\/jats:title>\n                  <jats:p>An observational study of patients admitted to the Massachusetts General Hospital with fractures between January 1, 2016, and October 31, 2023, cared for by the FLS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>Ergocalciferol 50 000 international units (50ku-D2) oral daily for 3 to 7 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcomes Measures<\/jats:title>\n                  <jats:p>VDD prevalence. Efficacy of inpatient daily 50ku-D2 in raising serum 25-hydroxyvitamin D (25OHD) levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 2951 consecutive patients, 724 (24.53%) had VDD (defined by 25OHD \u2264 19\u2005ng\/mL). Men (252\/897, or 28.09%) were more likely than women (472\/2054, or 22.98%) to have VDD (P = .003). VDD was seen in 41.79% (117\/280), 24.41% (332\/1360), and 20.98% (275\/1311) of patients of aged \u226459, 60 to 79, and \u226580 years, respectively (P &amp;lt; .00001). Of the 1303 patients with hip fractures, 327 (25.09%) had VDD, which was associated with a longer length of stay (8.37 \u00b1 7.35 vs 7.23 \u00b1 4.78 days, P = .009) and higher trend of 30-day-readmission rate (13.63% vs 18.35%, P = .037). In a cohort of 32 patients with complete data, each dose of 50ku-D2 increased serum 25OHD by 3.62 \u00b1 2.35\u2005ng\/mL without affecting serum calcium or creatinine levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>VDD was seen in nearly 25% of Massachusetts General Hospital FLS patients and more prevalent in male and younger patients. VDD was associated with longer length of stay and higher 30-day-readmission risk in patients with hip fracture. Daily 50ku-D2 appeared to be a practical way to quickly replete vitamin D in the inpatient setting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvae050","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T12:12:15Z","timestamp":1710245535000},"source":"Crossref","is-referenced-by-count":2,"title":["A Fracture Liaison Service to Address Vitamin D Deficiency for Patients Hospitalized for Osteoporotic Fracture"],"prefix":"10.1210","volume":"8","author":[{"given":"Xiaoxu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai, 200072 , China"},{"name":"Division of Endocrine, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Z","family":"Leder","sequence":"additional","affiliation":[{"name":"Division of Endocrine, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcy B","family":"Bolster","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuan V","family":"Ly","sequence":"additional","affiliation":[{"name":"Harvard Orthopaedic Trauma Initiative, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Franco-Garcia","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles T","family":"Pu","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-4809","authenticated-orcid":false,"given":"WuQiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Endocrine, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"issue":"4","key":"2024032819382388400_bvae050-B1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr Rev"},{"issue":"6","key":"2024032819382388400_bvae050-B2","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"2024032819382388400_bvae050-B3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2202106","article-title":"Supplemental vitamin D and incident fractures in midlife and older adults","volume":"387","author":"LeBoff","year":"2022","journal-title":"N Engl J Med"},{"issue":"7","key":"2024032819382388400_bvae050-B4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJMoa055218","article-title":"Women's health initiative I. 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