{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:35Z","timestamp":1753883615088,"version":"3.41.2"},"reference-count":51,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FIS-PI19\/00166"],"award-info":[{"award-number":["FIS-PI19\/00166"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica"},{"name":"Hospital Infantil Universitario Ni\u00f1o Jes\u00fas"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Anomalies in the growth hormone (GH)\/insulin-like growth factor (IGF) axis, are common in children with type 1 diabetes mellitus (T1DM), even in those reaching a normal or near-normal final height. However, concentrations of the IGF bioavailability regulatory factors (pappalysins [PAPP-As] and stanniocalcins [STCs]) have not been reported in children with T1DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine serum concentrations of PAPP-As and STCs in children at diagnosis of T1DM and after insulin treatment and the correlation of these factors with other members of the GH\/IGF axis, beta-cell insulin reserve, auxology, and nutritional status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A single-center prospective observational study including 47 patients (59.5% male), with T1DM onset at median age of 9.2 years (interquartile range: 6.3, 11.9) was performed. Blood and anthropometric data were collected at diagnosis and after 6 and 12 months of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At 6 and 12 months after T1DM diagnosis, there was improvement in the metabolic control (decrease in glycated hemoglobin [HbA1c] at 12 months \u22123.66 [95% CI: \u22124.81, \u22122.05], P = .001), as well as in body mass index SD and height SD (not statistically significant). STC2 increased (P &amp;lt; .001) and PAPP-A2 decreased (P &amp;lt; .001) at 6 and 12 months of treatment onset (P &amp;lt; .001), which was concurrent with increased total IGF-I and IGF-binding protein concentrations, with no significant modification in free IGF-I concentrations. HbA1c correlated with PAPP-A2 (r = +0.41; P &amp;lt; .05) and STC2 (r = \u22120.32; P &amp;lt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Implementation of insulin treatment after T1DM onset modifies various components of the circulating IGF system, including PAPP-A2 and STC2. How these modifications modulate linear growth remains unknown.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvae081","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T13:31:46Z","timestamp":1713792706000},"source":"Crossref","is-referenced-by-count":0,"title":["Implication of Pappalysins and Stanniocalcins in the Bioavailability of IGF-I in Children With Type 1 Diabetes Mellitus"],"prefix":"10.1210","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-4028","authenticated-orcid":false,"given":"Mar\u00eda","family":"G\u00fcemes","sequence":"first","affiliation":[{"name":"Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Research Institute La Princesa , 28009 Madrid , 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-6784","authenticated-orcid":false,"given":"Sandra","family":"Canelles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Research Institute La Princesa , 28009 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-7545","authenticated-orcid":false,"given":"Vicente","family":"Barrios","sequence":"additional","affiliation":[{"name":"Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Research Institute La Princesa , 28009 Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u03ccn (CIBEROBN), Instituto de Salud Carlos III , 28029 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-0276","authenticated-orcid":false,"given":"Jes\u00fas","family":"Argente","sequence":"additional","affiliation":[{"name":"Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Research Institute La Princesa , 28009 Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u03ccn (CIBEROBN), Instituto de Salud Carlos III , 28029 Madrid , Spain"},{"name":"Department of Pediatrics, Universidad Aut\u00f3noma de Madrid , 28029 Madrid , Spain"},{"name":"IMDEA, Food Institute, CEIUAM+CSI , 28049 Madrid , 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