{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:22:34Z","timestamp":1787714554264,"version":"build-2784847793"},"reference-count":39,"publisher":"The Endocrine Society","issue":"6","funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["Z1A HD008985"],"award-info":[{"award-number":["Z1A HD008985"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Treatment for transmasculine youth (TMY) can involve testosterone treatment and is sometimes preceded by gonadotropin-releasing hormone agonist (GnRHa) treatment for puberty blockade. GnRHas can increase final height in birth-assigned females with central precocious puberty. Maximizing final adult height (FAH) is an important outcome for many TMY.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Our objective was to determine how GnRHa treatment before testosterone impacts FAH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective cohort study at 5 US transgender health clinics. Participants were 32 TMY treated with GnRHas in early to midpuberty before testosterone (GnRHa + T group) and 62 late\/postpubertal TMY treated with testosterone only (T-only group).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The difference between FAH minus midparental target height (MPTH) was +2.3 \u00b1 5.7\u2005cm and \u22122.2 \u00b1 5.6\u2005cm in the GnRHa + T and T-only groups, respectively (P &amp;lt; .01). In the GnRHa + T group, FAH was 1.8 \u00b1 3.4\u2005cm greater than predicted adult height (PAH) (P &amp;lt; .05) and FAH vs initial height (IH) z-score was 0.5 \u00b1 1.2 vs 0.16 \u00b1 1.0 (P &amp;lt; .05). After adjusting for patient characteristics, each additional month of GnRHa monotherapy increased FAH by 0.59\u2005cm (95% CI 0.31, 0.9\u2005cm), stage 3 breast development at start of GnRHa was associated with 6.5\u2005cm lower FAH compared with stage 2 (95% CI \u221210.43, \u22122.55), and FAH was 7.95\u2005cm greater in the GnRHa + T group than in T-only group (95% CI \u221210.85, \u22125.06).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Treatment with GnRHa in TMY in early puberty before testosterone increases FAH compared with MPTH, PAH, IH, and TMY who only received testosterone in late\/postpuberty. TMY considering GnRHas should be counseled that GnRHas may mildly increase their FAH if started early.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvae089","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T18:19:18Z","timestamp":1714673958000},"source":"Crossref","is-referenced-by-count":5,"title":["Pubertal Suppression in Early Puberty Followed by Testosterone Mildly Increases Final Height in Transmasculine Youth"],"prefix":"10.1210","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-2859","authenticated-orcid":false,"given":"Rebecca W","family":"Persky","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Children's National Hospital , Washington, DC 20010 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Apple","sequence":"additional","affiliation":[{"name":"Craig-Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia , Philadelphia, PA 19178 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-1628","authenticated-orcid":false,"given":"Nadia","family":"Dowshen","sequence":"additional","affiliation":[{"name":"Craig-Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia , Philadelphia, PA 19178 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse","family":"Pine","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Chase Brexton Health Care , Baltimore, MD 21201 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jax","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Ann and Robert H. 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