{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:14:21Z","timestamp":1779920061291,"version":"3.53.1"},"reference-count":42,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Testosterone concentrations, albeit rarely, may be in the normal range (&amp;gt;3.0 ng\/mL) in men with a prolactin-secreting pituitary adenoma (PSPA-nt). The evolution of total, bioavailable testosterone, gonadotropin levels, and that of graded symptoms of testosterone deficiency (TD) are uncertain in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective case-control longitudinal study at a tertiary referral center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From 287 men, we selected 25 PSPA-nt men undergoing prolactin normalization (&amp;lt;20.0 ng\/mL) during the follow-up. Graded symptoms of TD were investigated by structured interviews. Biochemical changes and TD symptoms were compared to those of a matched cohort of 61 men with pituitary neoplasms and normal testosterone levels (PA-nt).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Baseline testosterone levels were similar between PSPA-nt and PA-nt subjects. The prevalence of specific and suggestive symptoms of TD was higher in PSPA-nt (20% and 68%) than in PAnt (3.3 and 29.5%; P = .02 and P = .0015, respectively). At the follow-up, total and bioavailable testosterone levels increased in PSPA-nt but not in PA-nt patients (\u0394 change: 1.28 \u00b1 2.1 vs0.03 \u00b1 1.5 ng\/mL, + 0.33 \u00b1 0.55 vs-0.26 \u00b1 0.60 ng\/mL; P = .0028 and P = .0088, respectively). LH and FSH levels also increased in PSPA-nt men (P &amp;lt; .05). Specific and suggestive, but not nonspecific symptoms of TD, improved only in PSPA-nt men (P &amp;lt; .05 for both). Baseline testosterone and LH were the strongest predictors of testosterone improvement in PSPA-nt patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite having normal testosterone levels at baseline, patients with PSPA-nt experience a relief of TD symptoms and an improvement of their pituitary-gonadal axis function following prolactin normalization, especially when baseline TT and LH levels are in the low-normal range.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvae135","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:37:46Z","timestamp":1721129866000},"source":"Crossref","is-referenced-by-count":2,"title":["Increase in Testosterone Levels and Improvement of Clinical Symptoms in Eugonadic men With a Prolactin-secreting Adenoma"],"prefix":"10.1210","volume":"8","author":[{"given":"Lea","family":"Carlier","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Reproductive Diseases, Universit\u00e9 Paris-Saclay, Inserm UMRS1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d'Endocrinologie et des Maladies de la Reproduction , 94275 Le Kremlin-Bic\u00eatre , France"},{"name":"Department of Endocrinology, H\u00f4pital Ambroise Par\u00e9, Assistance Publique-H\u00f4pitaux de Paris , 92100 Boulogne Billancourt , France"},{"name":"UE4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines Montigny-le-Bretonneux , 78000 Versailles , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Reproductive Diseases, Universit\u00e9 Paris-Saclay, Inserm UMRS1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d'Endocrinologie et des Maladies de la Reproduction , 94275 Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Cazabat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, H\u00f4pital Ambroise Par\u00e9, Assistance Publique-H\u00f4pitaux de Paris , 92100 Boulogne Billancourt , France"},{"name":"UE4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines Montigny-le-Bretonneux , 78000 Versailles , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Daclin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Reproductive Diseases, Universit\u00e9 Paris-Saclay, Inserm UMRS1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d'Endocrinologie et des Maladies de la Reproduction , 94275 Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Reproductive Diseases, Universit\u00e9 Paris-Saclay, Inserm UMRS1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d'Endocrinologie et des Maladies de la Reproduction , 94275 Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Hage","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, H\u00f4pital Ambroise Par\u00e9, Assistance Publique-H\u00f4pitaux de Paris , 92100 Boulogne Billancourt , France"},{"name":"UE4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines Montigny-le-Bretonneux , 78000 Versailles , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Trabado","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Pharmacogenetics and Hormonology, Universit\u00e9 Paris-Saclay, Inserm UMRS1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service de G\u00e9n\u00e9tique Mol\u00e9culaire, Pharmacog\u00e9n\u00e9tique et Hormonologie , 94275 Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Reproductive Diseases, Universit\u00e9 Paris-Saclay, Inserm UMRS1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d'Endocrinologie et des Maladies de la Reproduction , 94275 Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-8046","authenticated-orcid":false,"given":"Luigi","family":"Maione","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Reproductive Diseases, Universit\u00e9 Paris-Saclay, Inserm UMRS1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d'Endocrinologie et des Maladies de la Reproduction , 94275 Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"2","key":"2024082703540365600_bvae135-B1","doi-asserted-by":"crossref","first-page":"101290","DOI":"10.1016\/j.beem.2019.101290","article-title":"The epidemiology, diagnosis and treatment of prolactinomas: the old and the new","volume":"33","author":"Chanson","year":"2019","journal-title":"Best Pract Res Clin 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Proportion of cases exhibiting recovery of pituitary function","volume":"5","author":"Sibal","year":"2002","journal-title":"Pituitary"},{"issue":"3","key":"2024082703540365600_bvae135-B26","first-page":"154","article-title":"The factors associated with the persistence of hypogonadism in male patients with prolactinoma","volume":"43","author":"Piskinpasa","year":"2022","journal-title":"Neuro Endocrinol Lett"},{"issue":"5","key":"2024082703540365600_bvae135-B27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jsxmed\/qdad025","article-title":"Association between comorbidities and longitudinal changes in total testosterone among men from the Baltimore longitudinal study of aging","volume":"20","author":"Carto","year":"2023","journal-title":"J Sex Med"},{"key":"2024082703540365600_bvae135-B28","doi-asserted-by":"crossref","first-page":"35539","DOI":"10.1038\/srep35539","article-title":"Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of 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