{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:29:46Z","timestamp":1791325786640,"version":"4.3.1"},"reference-count":64,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["9039-00298B"],"award-info":[{"award-number":["9039-00298B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF17OC0027248"],"award-info":[{"award-number":["NNF17OC0027248"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009317","name":"Faculty of Health and Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Excessive eating and intake of a Western diet negatively affect the intestinal immune system, resulting in compromised glucose homeostasis and lower gut bacterial diversity. The G protein\u2013coupled receptor GPR183 regulates immune cell migration and intestinal immune response and has been associated with tuberculosis, type 1 diabetes, and inflammatory bowel diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We hypothesized that with these implications, GPR183 has an important immunometabolic role and investigated this using a global Gpr183 knockout mouse model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Wild-type (WT) and Gpr183-deficient (Gpr183\u2013\/\u2013) mice were fed a high-fat, high-sucrose diet (HFSD) for 15 weeks. We investigated changes in weight, body composition, fecal immunoglobulin A (IgA) levels, fecal microbiome, and glucose tolerance before and after the diet. Macrophage infiltration into visceral fat was determined by flow cytometry, and hepatic gene expression was measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A sexual dimorphism was discovered, whereby female Gpr183\u2013\/\u2013 mice showed adverse metabolic outcomes compared to WT counterparts with inferior glucose tolerance, lower fecal IgA levels, and increased macrophage infiltration in visceral fat. In contrast, male Gpr183\u2013\/\u2013 mice had significantly lower fasting blood glucose after diet than male WT mice. Liver gene expression showed reduced inflammation and macrophage markers in Gpr183\u2013\/\u2013 livers, regardless of sex, while the pancreatic islet area did not differ between the groups. No conclusive differences were found after microbiome sequencing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Gpr183 maintains metabolic homeostasis in female but not in male mice independent of diet. If confirmed in humans, future therapy targeting GPR183 should consider this sexual dimorphism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvae188","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T21:57:23Z","timestamp":1730239043000},"source":"Crossref","is-referenced-by-count":2,"title":["Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice"],"prefix":"10.1210","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-0345","authenticated-orcid":false,"given":"Liv","family":"von Voss","sequence":"first","affiliation":[{"name":"Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8821-8191","authenticated-orcid":false,"given":"Tulika","family":"Arora","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research and Medical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-8684","authenticated-orcid":false,"given":"Juliana","family":"Assis","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research and Medical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]},{"name":"National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Department of Immunotechnology, Lund University , SE 223 63 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-5466","authenticated-orcid":false,"given":"Katharina B","family":"Kuentzel","sequence":"additional","affiliation":[{"name":"Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-8502","authenticated-orcid":false,"given":"Kristine N","family":"Arfelt","sequence":"additional","affiliation":[{"name":"Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-654X","authenticated-orcid":false,"given":"Mark K","family":"N\u00f8hr","sequence":"additional","affiliation":[{"name":"Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-3950","authenticated-orcid":false,"given":"Trisha J","family":"Grevengoed","sequence":"additional","affiliation":[{"name":"Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0886-9101","authenticated-orcid":false,"given":"Manimozhiyan","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research and Medical Sciences, University of Copenhagen , DK 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-9273","authenticated-orcid":false,"given":"Thomas","family":"Mandrup-Poulsen","sequence":"additional","affiliation":[{"name":"Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen , DK 2200 Copenhagen 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