{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:50:30Z","timestamp":1773186630917,"version":"3.50.1"},"reference-count":42,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Perth Children\u2019s Hospital Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Septo-optic dysplasia (SOD) is a major cause of congenital hypopituitarism and is known to be associated with overweight and obesity in up to 44% of children. Given the role of the hypothalamus in hormonal regulation, we sought to assess the association of resting energy expenditure (REE), appetite and physical activity with SOD.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To characterize REE and other metabolic features in patients with SOD and evaluate relationships with elevated body mass index (BMI).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Children with SOD above 5 years of age attending Perth Children's Hospital participated. A CosMED Q-NRG indirect calorimeter was used to calculate mean measure REE (mREE). This was compared with predictive REE (pREE) based on the Schofield equation to determine mREE\/pREE quotient. A BMI z-score &gt;1 was considered elevated. Parents\/carers completed a questionnaire about pituitary function, the Hyperphagia Questionnaire and the Sleep Disturbances Scale for Children (SDSC).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Twenty-six participants underwent testing (9 female, mean age 12.1 years) with 11 having elevated BMI and 15 with pituitary hormone deficiencies. Mean mREE was 1309\u2005kcal\/day (838-1732), mREE\/pREE quotient was 88.8% \u00b1 10.1. mREE\/pREE quotient was similar in those with elevated BMI compared with normal BMI (83.3% \u00b1 12.5 vs 92.1% \u00b1 7.2, P = .068). Those with midline defects had a higher mREE\/pREE quotient (91.8% \u00b1 8.1 vs 80.4% \u00b1 11.3, P = .026). Hyperphagia and SDSC scores were similar between BMI groups. Hyperphagia domain scores were higher in children with multiple hypopituitarism, pituitary structural defects, and normal septum pellucidum (P = .044, .042, and .033, respectively).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Children with SOD had lower mREE than predicted and hyperphagia scores were higher in those with biochemical or structural pituitary changes, suggesting that hypothalamic dysfunction could drive BMI elevation in SOD. Indirect calorimetry may be used to guide the management of overweight and obesity in SOD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/jendso\/bvaf031","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T17:58:36Z","timestamp":1740419916000},"source":"Crossref","is-referenced-by-count":1,"title":["Resting Energy Expenditure and Metabolic Features in Children With Septo-Optic Dysplasia"],"prefix":"10.1210","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8108-2364","authenticated-orcid":false,"given":"David J","family":"Cullingford","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital , Nedlands, WA 6009 ,","place":["Australia"]},{"name":"The Centre for Child Health Research, The Kids Research Institute Australia, University of Western Australia , Nedlands, WA 6009 ,","place":["Australia"]},{"name":"Faculty of Health & Medical Sciences, University of Western Australia , Crawley, WA 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital , Nedlands, WA 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-1735","authenticated-orcid":false,"given":"Mary B","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital , Nedlands, WA 6009 ,","place":["Australia"]},{"name":"The Centre for Child Health Research, The Kids Research Institute Australia, University of Western Australia , Nedlands, WA 6009 ,","place":["Australia"]},{"name":"The Centre for Child Health Research, University of Western Australia , Crawley, WA 6009 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,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5824-9402","authenticated-orcid":false,"given":"A Marie","family":"Blackmore","sequence":"additional","affiliation":[{"name":"The Centre for Child Health Research, The Kids Research Institute Australia, University of Western Australia , Nedlands, WA 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-9037","authenticated-orcid":false,"given":"Jenny","family":"Downs","sequence":"additional","affiliation":[{"name":"The Centre for Child Health Research, The Kids Research Institute Australia, University of Western Australia , Nedlands, WA 6009 ,","place":["Australia"]},{"name":"Curtin School of Allied Health, Curtin University , Bentley, WA 6845 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-271X","authenticated-orcid":false,"given":"Catherine S Y","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital , Nedlands, WA 6009 ,","place":["Australia"]},{"name":"The Centre for Child Health Research, The Kids Research Institute Australia, University of Western Australia , Nedlands, WA 6009 ,","place":["Australia"]},{"name":"Faculty of Health & Medical Sciences, University of Western Australia , Crawley, WA 6009 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