{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:27:46Z","timestamp":1781566066713,"version":"3.54.5"},"reference-count":23,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Noninvasive measurement of bone marrow adipose tissue using magnetic resonance imaging and proton density fat fraction (PDFF) may enhance clinical fractures prediction in postmenopausal women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to assess the association between PDFF measurements and clinical fracture incidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A longitudinal study was conducted. Postmenopausal women with recent osteoporotic fractures (&amp;lt;12 months) and with osteoarthritis without fractures were included. Lumbar spine and proximal femur PDFFs were measured at baseline using water-fat imaging (WFI) and dual-energy x-ray absorptiometry scans. Clinical fractures were recorded during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 195 participants (mean age 67.4 \u00b1 10.0 years, body mass index 27.2 \u00b1 5.9\u2005kg\/m\u00b2), the PDFF (WFI-based) was higher at the proximal femur, particularly at the femoral head (90.0% \u00b1 4.9%), compared to the lumbar spine (57.8% \u00b1 9.6%). Over a mean follow-up period of 37.2 \u00b1 11.6 months, 7 participants died, 29 (14.9%) experienced incident clinical fractures, and 1 was lost to follow-up. The lack of an association between WFI-based PDFFs and the incidence of clinical fractures was demonstrated regardless of the region of measurement (hazard ratio [HR] = 0.95 [95% CI 0.67-1.35], P = 0.77 at the lumbar spine, HR = 1.07 [95% CI 0.71-1.63], P = 0.74 at the femoral neck). Stepwise regression analysis did not alter these findings, and the variable \u201crecent osteoporotic fractures\u201d was found to be significantly associated with incident clinical fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study found no evidence of a relationship between PDFF and clinical fracture incidence in postmenopausal women. Further studies are necessary involving larger cohorts and longer follow-up periods.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvaf033","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T17:58:52Z","timestamp":1740419932000},"source":"Crossref","is-referenced-by-count":4,"title":["Marrow Adiposity Content and Composition Are Not Associated With Incident Fragility Fractures in Postmenopausal Women: The ADIMOS Fracture Study"],"prefix":"10.1210","volume":"9","author":[{"given":"C\u00e9cile","family":"Philippoteaux","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Univ. Lille, CHU Lille , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Radiology and Musculoskeletal Imaging, Univ. Lille, CHU Lille, MABlab ULR 4490 , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Univ. Lille, CHU Lille , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-6471","authenticated-orcid":false,"given":"Emeline","family":"Cailliau","sequence":"additional","affiliation":[{"name":"Biostatistics Department, CHU Lille , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Ruschke","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich , 81675 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios C","family":"Karampinos","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich , 81675 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cotten","sequence":"additional","affiliation":[{"name":"Department of Radiology and Musculoskeletal Imaging, Univ. 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