{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:41:51Z","timestamp":1791906111798,"version":"4.3.4"},"reference-count":32,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Rathke\u2019s cleft cyst can lead to visual and pituitary dysfunction. Surgical decompression may alleviate these issues, but the decision to operate remains controversial because of the risk of worsening function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective analysis was conducted on 80 patients who underwent endoscopic transnasal transsphenoidal surgery for Rathke\u2019s cleft cyst from April 2018 to April 2024. Clinical outcomes were assessed using magnetic resonance imaging, intraoperative findings, and histopathology to evaluate factors associated with recovery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After a median follow-up of 13.5 months (interquartile range: 6-30.8 months), anterior pituitary function significantly improved in patients with cysts that did not compress the optic nerve and had minimal thinning of the ganglion cell layer-inner plexiform layer (P &amp;lt; .05). Arginine vasopressin deficiency occurred significantly more often in patients with preoperative adult GH deficiency, a history of surgery, and evidence of inflammation in specimens on pathology (P &amp;lt; .05). Retinal nerve fiber layer thickness correlated with visual field impairment both before and after surgery, suggesting it may predict visual recovery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Decompression of Rathke\u2019s cleft cysts can improve anterior pituitary function in patients with smaller cysts and minimal optic nerve pressure. Visual function will likely improve in those with minimal optic nerve fiber layer thinning. Therefore, preoperative optical coherence tomography and visual field testing are mandatory to set expectations regarding potential improvement in vision and anterior pituitary function following surgery. Patients with preoperative adult GH deficiency and a history of surgery are at higher risk of developing postoperative arginine vasopressin deficiency.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvaf093","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T18:35:07Z","timestamp":1747766107000},"source":"Crossref","is-referenced-by-count":3,"title":["Recovery of Pituitary and Visual Function After Rathke\u2019s Cleft Cyst Decompression: An 80-case Institutional Experience"],"prefix":"10.1210","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-5448","authenticated-orcid":false,"given":"Haruko","family":"Yoshimoto","sequence":"first","affiliation":[{"name":"Hypothalamic and Pituitary Center, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kato","sequence":"additional","affiliation":[{"name":"Hypothalamic and Pituitary Center, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Hypothalamic and Pituitary Center, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Shiramizu","sequence":"additional","affiliation":[{"name":"Hypothalamic and Pituitary Center, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Hypothalamic and Pituitary Center, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Hypothalamic and Pituitary Center, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-3388","authenticated-orcid":false,"given":"Naoko","family":"Inoshita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Tokyo Clinic , Tokyo 100-0004 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Tokyo Clinic , Tokyo 100-0004 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Nangyo Inagaki Eye Clinic , Chiba 272-0143 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Tanaka-Mizuno","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Prevention, Kobe Pharmaceutical University , Kobe 658-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-0816","authenticated-orcid":false,"given":"Shozo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Hypothalamic and Pituitary Center, Moriyama Memorial Hospital , Tokyo 134-0081 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"issue":"12","key":"2025062623252669900_bvaf093-B1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00701-007-1295-x","article-title":"Pituitary adenoma and concomitant Rathke's cleft cyst","volume":"149","author":"Noh","year":"2007","journal-title":"Acta Neurochir (Wien)"},{"key":"2025062623252669900_bvaf093-B2","doi-asserted-by":"publisher","first-page":"971364","DOI":"10.1155\/2015\/971364","article-title":"Spontaneous involution of a presumably Rathke's cleft cyst in a patient with slight subclinical hypopituitarism: a case report and review of the literature","volume":"2015","author":"Safatli","year":"2015","journal-title":"Case Rep Surg"},{"issue":"5","key":"2025062623252669900_bvaf093-B3","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3171\/2022.7.JNS22716","article-title":"Natural course of Rathke's cleft cysts and risk factors for progression","volume":"138","author":"Kinoshita","year":"2023","journal-title":"J Neurosurg"},{"issue":"6","key":"2025062623252669900_bvaf093-B4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3171\/2009.10.JNS091070","article-title":"Spontaneous involution of rathke cleft cysts: is it rare or just underreported?","volume":"112","author":"Amhaz","year":"2010","journal-title":"J Neurosurg"},{"issue":"2","key":"2025062623252669900_bvaf093-B5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/cen.13744","article-title":"Natural history of Rathke's cleft cysts: a retrospective analysis of a two centers experience","volume":"89","author":"Sala","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2025062623252669900_bvaf093-B6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11102-021-01197-6","article-title":"Surgical outcomes and quality of life in Rathke's cleft cysts undergoing endoscopic transsphenoidal resection: a multicentre study and systematic review of the literature","volume":"25","author":"Castle-Kirszbaum","year":"2022","journal-title":"Pituitary"},{"issue":"4","key":"2025062623252669900_bvaf093-B7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00701-020-04237-5","article-title":"Rathke's cleft cysts following transsphenoidal surgery: long-term outcomes and development of an optimal follow-up strategy","volume":"162","author":"Marcus","year":"2020","journal-title":"Acta Neurochir (Wien)"},{"issue":"1","key":"2025062623252669900_bvaf093-B8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00006123-199801000-00003","article-title":"Transsphenoidal management of 28 symptomatic Rathke's cleft cysts, with special reference to visual and hormonal recovery","volume":"42","author":"El-Mahdy","year":"1998","journal-title":"Neurosurgery"},{"issue":"3","key":"2025062623252669900_bvaf093-B9","doi-asserted-by":"publisher","first-page":"e0171960","DOI":"10.1371\/journal.pone.0171960","article-title":"Properties of pattern standard deviation in open-angle glaucoma patients with hemi-optic neuropathy and bi-optic neuropathy","volume":"12","author":"Heo","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"2025062623252669900_bvaf093-B10","first-page":"71","article-title":"Basic evaluation of blood cortisol measurement with Elecsys Cortisol II","volume":"73","author":"Kakizawa","year":"2016","journal-title":"Jpn J Med Pharm Sci"},{"issue":"1","key":"2025062623252669900_bvaf093-B11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1530\/EJE-07-0066","article-title":"A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency","volume":"157","author":"Chihara","year":"2007","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"2025062623252669900_bvaf093-B12","doi-asserted-by":"crossref","first-page":"e220504","DOI":"10.1530\/EC-22-0504","article-title":"Diagnosis and testing for growth hormone deficiency across the ages: a global view of the accuracy, caveats, and cut-offs for diagnosis","volume":"12","author":"Yuen","year":"2023","journal-title":"Endocr Connect"},{"issue":"6","key":"2025062623252669900_bvaf093-B13","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.3171\/2019.8.JNS191103","article-title":"Endoscopic endonasal cyst fenestration into the sphenoid sinus using the mucosa coupling method for symptomatic Rathke's cleft cyst: a novel method for maintaining cyst drainage to prevent recurrence","volume":"133","author":"Kino","year":"2019","journal-title":"J Neurosurg"},{"issue":"2","key":"2025062623252669900_bvaf093-B14","doi-asserted-by":"publisher","first-page":"E400","DOI":"10.1227\/01.NEU.0000363746.84763.A5","article-title":"The endoscopic diving technique in pituitary and cranial base surgery: technical note","volume":"66","author":"Locatelli","year":"2010","journal-title":"Neurosurgery"},{"key":"2025062623252669900_bvaf093-B15","first-page":"59","article-title":"An introduction to the statistical free software HAD: suggestions to improve teaching, learning and practice data analysis","volume":"1","author":"Shimizu","year":"2016","journal-title":"Jpn J Media Inform Commun Stud"},{"issue":"4","key":"2025062623252669900_bvaf093-B16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3171\/jns.2004.101.4.0571","article-title":"Rathke cleft cysts","volume":"101","author":"Laws","year":"2004","journal-title":"J Neurosurg"},{"issue":"1","key":"2025062623252669900_bvaf093-B17","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/2011.5.FOCUS1175","article-title":"Symptomatic Rathke cleft cysts: extent of resection and surgical complications","volume":"31","author":"Higgins","year":"2011","journal-title":"Neurosurg Focus"},{"issue":"6","key":"2025062623252669900_bvaf093-B18","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.3171\/2013.8.JNS13777","article-title":"Individualized surgical strategies for Rathke Cleft cyst based on cyst location","volume":"119","author":"Fan","year":"2013","journal-title":"J Neurosurg"},{"issue":"5","key":"2025062623252669900_bvaf093-B19","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3171\/2024.3.JNS232740","article-title":"Endoscopic endonasal resection of rathke cleft cysts: a single-institution analysis of 148 consecutive patients","volume":"141","author":"Algattas","year":"2024","journal-title":"J Neurosurg"},{"key":"2025062623252669900_bvaf093-B20","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.1016\/j.wneu.2019.08.196","article-title":"Clinicopathologic characteristics and endoscopic surgical outcomes of symptomatic Rathke's cleft cyst","volume":"132","author":"Cabuk","year":"2019","journal-title":"World Neurosurg"},{"issue":"3","key":"2025062623252669900_bvaf093-B21","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1227\/01.NEU.0000374768.16291.03","article-title":"Endocrinopathy, vision, headache and recurrence after transsphenoidal surgery for Rathke cleft cysts","volume":"67","author":"Wait","year":"2010","journal-title":"Neurosurgery"},{"issue":"5","key":"2025062623252669900_bvaf093-B22","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1227\/NEU.0b013e318228bcea","article-title":"Suprasellar Rathke cleft cysts: clinical presentation and treatment outcomes","volume":"69","author":"Potts","year":"2011","journal-title":"Neurosurgery"},{"issue":"2","key":"2025062623252669900_bvaf093-B23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1530\/EJE-12-0801","article-title":"Magnetic resonance imaging of CNS in 15043 children with GH deficiency in KIGS (Pfizer International Growth Database)","volume":"168","author":"Maghnie","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"2025062623252669900_bvaf093-B24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.wneu.2022.03.011","article-title":"Diagnostic and prognostic utility of optical coherence tomography in patients with sellar suprasellar lesions with chiasm impingement: a systematic review\/meta-analysis","volume":"162","author":"Jeong","year":"2022","journal-title":"World Neurosurg"},{"issue":"2","key":"2025062623252669900_bvaf093-B25","doi-asserted-by":"publisher","first-page":"e24069","DOI":"10.1097\/MD.0000000000024069","article-title":"Impact of binocular integrated visual field defects on healthy related quality of life in glaucoma","volume":"100","author":"Zhao","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"2025062623252669900_bvaf093-B26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3171\/jns.2002.96.2.0209","article-title":"Change in the epithelium of Rathke cleft cyst associated with inflammation","volume":"96","author":"Hama","year":"2002","journal-title":"J Neurosurg"},{"issue":"4","key":"2025062623252669900_bvaf093-B27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3171\/jns.2004.101.4.0577","article-title":"Surgery for Rathke cleft cysts; technical considerations and outcomes","volume":"101","author":"Benveniste","year":"2004","journal-title":"J Neurosurg"},{"issue":"1","key":"2025062623252669900_bvaf093-B28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3171\/jns.2004.100.1.0033","article-title":"Surgical treatment of symptomatic Rathke cleft cysts: clinical features and results with special attention to recurrence","volume":"100","author":"Kim","year":"2004","journal-title":"J Neurosurg"},{"issue":"2","key":"2025062623252669900_bvaf093-B29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3171\/jns.2005.102.2.0189","article-title":"Surgical outcomes in 118 patients with Rathke cleft cyst","volume":"102","author":"Aho","year":"2005","journal-title":"J Neurosurg"},{"issue":"4","key":"2025062623252669900_bvaf093-B30","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3171\/2015.8.JNS151282","article-title":"The long-term recurrence of Rathke's cleft cysts as predicted by histology but not by surgical procedure","volume":"125","author":"Kinoshita","year":"2016","journal-title":"J Neurosurg"},{"issue":"3","key":"2025062623252669900_bvaf093-B31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3171\/2017.11.JNS171498","article-title":"Long-term surgical outcomes following transsphenoidal surgery in patients with Rathke's cleft cyst","volume":"130","author":"Lin","year":"2019","journal-title":"J Neurosurg"},{"issue":"1","key":"2025062623252669900_bvaf093-B32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1530\/EJE-11-0142","article-title":"Outcome in surgically treated Rathke's cleft cysts: long-term monitoring needed","volume":"165","author":"Trifanescu","year":"2011","journal-title":"Eur J Endocrinol"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvaf093\/63247778\/bvaf093.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/9\/8\/bvaf093\/63247778\/bvaf093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/9\/8\/bvaf093\/63247778\/bvaf093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T03:25:35Z","timestamp":1750994735000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvaf093\/8139093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,6,9]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvaf093","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,5,20]]},"article-number":"bvaf093"}}