{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:21:12Z","timestamp":1787714472857,"version":"build-2784847793"},"reference-count":58,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sygeforsikringen \u201cdanmark\u201d","award":["2022-0153"],"award-info":[{"award-number":["2022-0153"]}]},{"name":"Danish Health Authority","award":["03-0802-296"],"award-info":[{"award-number":["03-0802-296"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Some transgender individuals wish to become biological parents in the future and transfeminine persons may be offered cryopreservation of semen before starting hormone therapy. However, there is a lack of knowledge about semen cryopreservation outcomes among transfeminine adolescents seeking gender-affirming care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate transfeminine adolescents who decide for or against semen cryopreservation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a retrospective observational national cohort study of 58 transfeminine individuals aged &amp;lt;18 years, assessing clinical data, semen parameters, and reproductive hormone levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 58 individuals, 23 (39.7%) opted for semen cryopreservation and successfully collected a semen sample. They were older and more advanced in pubertal development compared with those who did not: median age was 16.4 years (range, 13.7-19.4) vs 15.8 years (11.7-17.9); Tanner stage G5 (4-5) vs G3 (2-4); and testis volume 20\u2005mL (15-25) vs 8\u2005mL (3-20). Among 17 individuals with no prior hormone therapy, the median sperm concentration was 11.1 \u00d7 106\/mL (0.02-163), semen volume 1.8\u2005mL (0.2-3.9), total sperm count 17.8 \u00d7 106 (0.1-214.2), and percentage of progressively motile spermatozoa 46% (8-74). Reproductive hormones were within normal ranges for age and registered sex at birth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The percentage of adolescents opting for semen cryopreservation was comparable to other countries with a publicly financed national healthcare system. Overall, semen quality was impaired.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvaf105","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T13:22:05Z","timestamp":1749561725000},"source":"Crossref","is-referenced-by-count":3,"title":["Semen Cryopreservation and Semen Quality in Transfeminine Adolescents Prior to Hormone Therapy"],"prefix":"10.1210","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5076-2336","authenticated-orcid":false,"given":"Mohsin","family":"Aslam","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen ,","place":["Denmark"]},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet and University of Copenhagen , 2100 Copenhagen 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