{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:22:28Z","timestamp":1754162548306,"version":"3.41.2"},"reference-count":53,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish government"},{"DOI":"10.13039\/501100001034","name":"ALF","doi-asserted-by":"publisher","award":["ALFGBG-1006115","ALFGBG-965744","ALFGBG-437971"],"award-info":[{"award-number":["ALFGBG-1006115","ALFGBG-965744","ALFGBG-437971"]}],"id":[{"id":"10.13039\/501100001034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>It is unclear whether thyroid hormone levels are associated with the risk of mortality, cardiovascular disease (CVD) events, or cancer in men with normal TSH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We analyzed if serum free T4 (FT4) or TSH is associated with the risk of mortality, incident CVD events, or cancer in Swedish men.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Elderly men (n = 1801; mean age 75 years) in the Gothenburg and Malm\u00f6 subcohorts of the prospective, population-based Osteoporotic Fractures in Men Study-Sweden study were followed for median 12.2 years regarding all-cause mortality [1207 (67%) died] and for median 5.1 years regarding incident CVD events (n = 338) and cancer (n = 249). The statistical analyses included Cox proportional hazards regression with adjustment for covariates including prevalent atrial fibrillation (AF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Serum FT4 (per SD increase) was associated with increased risk of mortality [men with normal TSH: fully adjusted hazard ratio (HR) 1.23, 95% confidence interval (CI): 1.11-1.35] and incident CVD events (HR 1.25, 95% CI: 1.05-1.48) but not with the risk of cancer. The association between FT4 and CVD events was mainly due to increased risk of cerebrovascular (CBV) events (HR 1.56, 95% CI: 1.24-1.96). Finally, TSH was not associated with the risk of mortality, CVD events, or cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>FT4, but not TSH, is a predictor of mortality risk in elderly men. The association between FT4 and elevated risk of CVD events was mostly due to increased risk of CBV events, which remained significant also after adjustment for prevalent AF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvaf121","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:02:42Z","timestamp":1752746562000},"source":"Crossref","is-referenced-by-count":0,"title":["Higher Serum Free T4 Is Associated With Increased Risk of Mortality and Cerebrovascular Events in Elderly Men"],"prefix":"10.1210","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-6405","authenticated-orcid":false,"given":"Johan","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Osteoporosis Center, Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg SE-413 45 ,","place":["Sweden"]},{"name":"Department of Internal Medicine, Region V\u00e4stra G\u00f6taland, Skaraborg Central Hospital , Sk\u00f6vde SE-541 85 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-2805","authenticated-orcid":false,"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Osteoporosis Center, Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg SE-413 45 ,","place":["Sweden"]},{"name":"Department of Drug Treatment, Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital , Gothenburg SE-413 45 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus K","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Orthopedics, Clinical and Molecular Osteoporosis Research Unit, Skane University Hospital, Lund University , Malm\u00f6 SE-205 02 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Tivesten","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg SE-413 45 ,","place":["Sweden"]},{"name":"Department of Endocrinology, Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland , Gothenburg SE-413 45 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Herlitz","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Nephrology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg SE-413 45 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-1431","authenticated-orcid":false,"given":"Mattias","family":"Lorentzon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Osteoporosis Center, Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg SE-413 45 ,","place":["Sweden"]},{"name":"Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg SE-413 45 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Lewerin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Coagulation, Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital , Gothenburg SE-413 45 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