{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:47:51Z","timestamp":1763142471737,"version":"3.45.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031031","name":"University Children's Hospital Zurich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Career Development Awards K23"},{"name":"National Centers for Translational Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Sources of androgen overproduction in peripubertal girls with overweight\/obesity (excess weight [EW]) remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess 17-hydroxyprogesterone (17-OHP) responses to recombinant human chorionic gonadotropin (r-hCG) in peripubertal girls with and without EW. We hypothesized that 17-OHP responses are exaggerated in late pubertal girls with EW compared to those without EW, but similar in early pubertal girls with and without EW.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study conducted at an academic clinical research unit included 45 girls ages 7 to 18 years: 6 early pubertal (Tanner 1-3) with EW and 8 without; 20 late pubertal (Tanner 4-5) with EW and 11 without. Research volunteers took oral dexamethasone (1\u2005mg) at 22:00\u2005hours on study days 1 and 2. On study day 2, volunteers had blood withdrawal at 08:00\u2005hours and r-hCG administration (25\u2005mcg intravenously) at 09:00\u2005hours, with repeat blood withdrawal at 09:00\u2005hours on study day 3; the 17-OHP increment was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>17-OHP responsiveness was 2.31-fold (95% CI, 1.13-4.73) greater in early pubertal girls with EW compared to those without (Bonferroni-corrected P = .023), while responses were similar between late pubertal girls with and without EW. 17-OHP responsiveness in late pubertal girls with EW were 59% (95% CI, 9%-81%) lower than early pubertal girls with EW (Bonferroni-corrected P = .027), while responses were similar between late and early pubertal girls without EW.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ovarian responsiveness to r-hCG stimulation during early puberty may be exaggerated in the setting of EW, but excess-weight status per se may not promote long-term ovarian hyperresponsiveness to r-hCG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvaf154","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:20:51Z","timestamp":1759234851000},"source":"Crossref","is-referenced-by-count":1,"title":["Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight"],"prefix":"10.1210","volume":"9","author":[{"given":"Melissa A","family":"Houghton","sequence":"first","affiliation":[{"name":"Undergraduate Medical Education, University of Virginia School of Medicine , Charlottesville, VA 22908 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-4982","authenticated-orcid":false,"given":"Christopher 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