{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:48:30Z","timestamp":1787021310443,"version":"build-2736575974"},"reference-count":41,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Adherence to recombinant GH treatment is crucial to achieve optimal adult height in children with growth disorders. Information on factors responsible for differences in adherence and growth in different countries is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate adherence and catch-up growth in children receiving GH using Easypod\u00ae auto-injectors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort analysis of adherence and height, from 481 children (55% boys) in 19 centers in France, from the Growzen\u00ae Connect database, from mid-2018 to end-2023. Adherence was classified as high (\u226585% of injections) or medium\/low (&amp;lt;85%). Gain in height SD score (HSDS) was evaluated after 1 and 2 years of GH treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High adherence was maintained throughout for 85% of patients. Among children who started young (mean age 6.3 years), 91% had high adherence over the first 2 years, significantly more than the 83% among those starting older (13.1 years) (P = .039). HSDS gain at 2 years for children with GH deficiency and born small for gestational age was +1.1 and +1.0, respectively, for children who started young and +0.6 and +0.6 for those starting older (P = .001 and.032, respectively), with no difference between disorders (P &amp;gt; .5). For children with high adherence, 2-year HSDS gain was significantly higher than for children with lower adherence (0.8 vs +0.5, P = .030).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children using Easypod exhibit high adherence, which aids clinical decision-making and patient engagement. Adherence and catch-up growth decrease with age. Indication for GH treatment had little impact, but overall catch-up growth was significantly greater with high adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvaf162","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:26:24Z","timestamp":1761045984000},"source":"Crossref","is-referenced-by-count":3,"title":["Adherence and Growth Outcomes in a Large Cohort of Children Treated With Recombinant GH Using a Connected Auto-injector"],"prefix":"10.1210","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-352X","authenticated-orcid":false,"given":"Michel","family":"Polak","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Diabetology and Gynecology, H\u00f4pital Universitaire Necker Enfants Malades, Centre des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement, Assistance Publique H\u00f4pitaux de Paris , Paris 75015 ,","place":["France"]},{"name":"INSERM U1016, Institut IMAGINE, Universit\u00e9 Paris Cit\u00e9 , Paris 75015 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Bouhours-Nouet","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology, Angers University Hospital , Angers 49000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-6244","authenticated-orcid":false,"given":"Paula","family":"van Dommelen","sequence":"additional","affiliation":[{"name":"Department of Child Health, The Netherlands Organization for Applied Scientific Research TNO , Schipholweg 77\u201389, 2316 ZL Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-0253","authenticated-orcid":false,"given":"Lilian","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Devices and Connected Solutions Engineering, Global Healthcare Operations, Ares Trading S.A. 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