{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:43:07Z","timestamp":1772548987183,"version":"3.50.1"},"reference-count":28,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008484","name":"BioMarin Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Achondroplasia is a skeletal dysplasia condition caused by reduced endochondral ossification resulting in disproportionate short stature and skeletal deformities, including thoracolumbar kyphosis (TLK) and spinal stenosis. Vosoritide, the first and only approved targeted therapy for achondroplasia, increases bone growth, but its impact on spinal morphology has not been assessed. The randomized, double-blind, placebo-controlled phase 2 CANOPY ACH-2I study (111-206; NCT03583697) evaluated the safety and efficacy of vosoritide in 75 children aged 0 to &amp;lt;5\u2005years. Interpedicular distance (IPD), sagittal width of the lumbar spinal canal, and TLK angle were measured on spinal radiographs taken at baseline and 1\u2005year after vosoritide or placebo treatment. Differences in least-squares mean (LSM) change from baseline (95% CI) between treatment groups were determined with an analysis of covariance model. Measurable improvements in IPD and spinal canal width across L1 to L5 were observed with vosoritide compared with placebo after 1\u2005year. L4 was the most impacted by vosoritide for IPD (LSM difference [95% CI], 0.509 [\u22120.034 to 1.052]\u2005mm, P = .066) and canal width (1.433 [0.547 to 2.320]\u2005mm, P = .002). Vosoritide treatment also reduced the natural increase in TLK angle in children 0 to &amp;lt;0.5\u2005years and provided greater improvements in children \u22650.5 to &amp;lt;5\u2005years. After 1\u2005year, fewer children treated with vosoritide (33.3%) vs placebo (59.3%) had pathological (\u226520\u00b0) TLK angles (P = .037). These preliminary results suggest that early vosoritide treatment may improve spinal morphology and reduce the risk of spinal stenosis in children with achondroplasia.<\/jats:p>\n                  <jats:p>Clinical Trial Information: NCT03583697.<\/jats:p>","DOI":"10.1210\/jendso\/bvag008","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:56:19Z","timestamp":1771505779000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of vosoritide on spine morphology in children with achondroplasia: 1-year results from a randomized phase 2 study"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-4461","authenticated-orcid":false,"given":"Melita","family":"Irving","sequence":"first","affiliation":[{"name":"Guy's and St. Thomas' NHS Foundation Trust, Evelina Children's Hospital , London SE1 7EH 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