{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:02:51Z","timestamp":1791576171104,"version":"4.3.4"},"reference-count":73,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Lumbar spine bone mineral density (BMD) rises sharply during puberty; earlier onset, as in central precocious puberty (CPP), may accelerate skeletal maturation and modify bone accrual.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess bone and body composition in girls with CPP\/early puberty (EP), premature thelarche (PT), and prepubertal controls (PC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We analyzed 184 girls aged 5-9 years with suspected CPP\/EP (108 CPP\/EP, 76 PT) and 47 PC. DXA assessed L1-L4 and total body less head (TBLH) BMD, bone mineral content (BMC), and body composition. Derived measures included bone mineral apparent density (BMAD), trabecular bone score (TBS), android\u2013gynoid fat ratio (A\/G), fat mass index (FMI), and fat-free mass index (FFMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Group CPP\/EP showed greater height, BMI SDS, bone age (BA), FM, lean mass, and FFMI than controls, with higher L1-L4 BMD (P &amp;lt; .001) and a trend for higher \u0394BMD L1-L4\u2013TBLH Z-score (P = .07); L1-L4 BMAD Z-scores were similar. Versus Group PT, Group CPP\/EP had higher \u0394height-target height SDS (P = .005), BA (P &amp;lt; .001), and lean mass (P = .03); Group PT had higher A\/G (P = .02) and TBS (P = .03). Within Group PT, girls with pubarche had higher height, BMI SDS, BA, FMI, A\/G (P = .02) and L1-L4 BMAD Z-scores (P = .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both CPP\/EP and PT showed higher fat and lean mass than controls, with PT marked by greater central adiposity. Only overweight\/obesity, and pubarche onset in PT, were associated with increased L1-L4 BMAD Z-scores. DXA provides additional insight into body composition and bone accrual in girls with early pubertal signs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag023","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:09:10Z","timestamp":1769767750000},"source":"Crossref","is-referenced-by-count":3,"title":["Bone and body composition by DXA in girls with precocious puberty, premature thelarche, and prepubertal controls"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-6501","authenticated-orcid":false,"given":"Daniela","family":"Fava","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 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Maria","family":"Allegri","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Patti","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 ,","place":["Italy"]},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16132 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-1158","authenticated-orcid":false,"given":"Roberto","family":"Gastaldi","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 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