{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:49:44Z","timestamp":1792093784666,"version":"4.4.0"},"reference-count":27,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PMP15\/00027"],"award-info":[{"award-number":["PMP15\/00027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union-ERDF","award":["PMP22\/00021"],"award-info":[{"award-number":["PMP22\/00021"]}]},{"name":"European Union -NextGenerationEU"},{"name":"M.P.-D"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an efficacy of 50%. Some biomarkers can predict patient response, potentially benefiting nonresponders by using personalized treatment approaches. The ACROFAST study revealed that the probability of disease control was 2.53 times higher (CI 1.30-4.80) with personalized treatment, and insulin-like growth factor 1 (IGF1) normalization occurred in 78% vs 53% of patients, compared with standard treatment (P &amp;lt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the cost-effectiveness of personalized medicine based on predictive biomarkers, from the results of the ACROFAST study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Post hoc analysis from the ACROFAST study comparing cost-effectiveness of a protocol of medical treatment based on predictive biomarkers to fgSRLs (n = 32) vs standard treatment (n = 36) for 12 months. Costs analyzed were visits, examinations, study of biomarkers (121\u20ac\/patient), and pharmacological treatment according to the prices established by the Spanish National Health Care System. Medium-term costs were evaluated, considering a projection of up to 2 years in uncontrolled cases, assuming positive and negative scenarios with additional monitoring costs and a 25% likelihood of disease progression per follow-up visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The personalized protocol reduced the average cost per patient required to achieve disease control by 22% (15 127\u20ac vs 19 420\u20ac). These results represent an annual saving of 15 263\u20ac per patient achieving hormonal control compared to the standard treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Personalized medicine, using a relatively straightforward biomarker-based protocol, enables a greater proportion of patients to attain hormonal control and proves to be a cost-effective strategy for managing acromegaly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag030","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:31:45Z","timestamp":1770726705000},"source":"Crossref","is-referenced-by-count":3,"title":["Cost-effectiveness of personalized medical treatment in acromegaly: a post hoc analysis of the ACROFAST study"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-5070","authenticated-orcid":false,"given":"Montserrat","family":"Marques-Pamies","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital General de Granollers , 08402 Granollers ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-7814","authenticated-orcid":false,"given":"Laura","family":"Ricou","sequence":"additional","affiliation":[{"name":"Research Group on Innovation, Health Economics and Digital Transformation\u2014Institut Germans Trias I Pujol, CRES\u2014Pompeu Fabra University , 08916 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-9119","authenticated-orcid":false,"given":"Joan","family":"Gil","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Germans Trias I Pujol Research Institute (IGTP) , 08916 Badalona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER, Unidad 747), Instituto de Salud Carlos III (ISCIII) , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Endocrinology and Nutrition, EndoERN, Research Center for Pituitary Diseases, Institut de Recerca Sant Pau (IIB-Sant Pau), Hospital Sant Pau , 08025 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Sampedro-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, La Princesa University Hospital , 28006 Madrid ,","place":["Spain"]},{"name":"Endocrine Research Unit, Instituto de Investigaci\u00f3n del Hospital de La Princesa , 28006 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina","family":"Biagetti","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER, Unidad 747), Instituto de Salud Carlos III (ISCIII) , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Endocrinology and Nutrition, Vall Hebron University Hospital , 08035 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Gim\u00e9nez-Palop","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Dos de Maig , 08025 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Arnau de Vilanova University Hospital , 25198 Lleida ,","place":["Spain"]},{"name":"Endocrine Research Unit, Lleida Institute for Biomedical Research Dr. Pifarr\u00e9 Foundation (IRBLleida) , 25198 Lleida ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department Hormonal Laboratory, Germans Trias I Pujol University Hospital , 08916 Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Carrato","sequence":"additional","affiliation":[{"name":"Department of Pathology, Germans Trias I Pujol University Hospital , 08916 Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Villar-Taibo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Cl\u00ednico de Santiago University Hospital , 15706 Santiago de Compostela ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Ram\u00f3n y Cajal University Hospital , 28034 Madrid ,","place":["Spain"]},{"name":"Endocrine Research Unit, Instituto de Investigaci\u00f3n Ram\u00f3n y Cajal (IRYCIS) , 28034 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Pr\u00edncipe de Asturias University Hospital , 28805 Alcal\u00e0 de Henares ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Sim\u00f3n-Muela","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Joan XXIII University Hospital , 43005 Tarragona ,","place":["Spain"]},{"name":"Endocrine Research Unit, Institut d\u00b4Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) , 43005 Tarragona ,","place":["Spain"]},{"name":"Departament of Medicine, Rovira I Virgili University (URV) , 43003 Tarragona ,","place":["Spain"]},{"name":"Endocrine Research Unit, Institut D\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) , 08908 Hospitalet de Llobregat ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Sim\u00f3-Servat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Mutua de Terrassa University Hospital , 08221 Terrassa ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Xifra","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Josep Trueta University Hospital , 17007 Girona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Germans Trias I Pujol University Hospital , 08916 Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Getafe University Hospital , 28905 Getafe ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Rosado","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Getafe University Hospital , 28905 Getafe ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Garc\u00eda-Centeno","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Gregorio Mara\u00f1\u00f3n University Hospital , 28007 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Zavala","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Joan XXIII University Hospital , 43005 Tarragona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia Alexandra","family":"Hanzu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Clinic University Hospital , 08036 Barcelona ,","place":["Spain"]},{"name":"Endocrine Research Unit, Institut D\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS) , 08036 Barcelona ,","place":["Spain"]},{"name":"Departament of Medicine, Universitat de Barcelona (UB) , 08036 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Mora","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Clinic University Hospital , 08036 Barcelona ,","place":["Spain"]},{"name":"Endocrine Research Unit, Institut D\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS) , 08036 Barcelona ,","place":["Spain"]},{"name":"Departament of Medicine, Universitat de Barcelona (UB) , 08036 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aulinas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER, Unidad 747), Instituto de Salud Carlos III (ISCIII) , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Endocrinology and Nutrition, EndoERN, Research Center for Pituitary Diseases, Institut de Recerca Sant Pau (IIB-Sant Pau), Hospital Sant Pau , 08025 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Vilarrasa","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Institut D\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) , 08908 Hospitalet de Llobregat ,","place":["Spain"]},{"name":"Department of Endocrinology and Nutrition, Bellvitge University Hospital , 08907 Hospitalet de Llobregat ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas (CIBERDEM), Instituto de Salud Carlos III (ISCIII) , 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bellvitge University Hospital , 08907 Bellvitge ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Librizzi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, 12 de Octubre University Hospital , 28041 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Calatayud","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, 12 de Octubre University Hospital , 28041 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"de Miguel Novoa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Cl\u00ednico San Carlos University Hospital , 28040 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alvarez-Escola","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, La Paz University Hospital , 28045 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pic\u00f3","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, General University Hospital Dr Balmis, Miguel Hern\u00e1ndez University , 03010 Alicante ,","place":["Spain"]},{"name":"Endocrine Research Unit, Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL) , 03010 Alicante ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Salinas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Getafe University Hospital , 28905 Getafe ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fajardo-Monta\u00f1ana","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, La Ribera University Hospital , 46600 Valencia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"C\u00e1mara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, La Fe University Hospital , 46026 Valencia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Bernab\u00e9u","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Ram\u00f3n y Cajal University Hospital , 28034 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Jord\u00e0","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Germans Trias I Pujol Research Institute (IGTP) , 08916 Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-6436","authenticated-orcid":false,"given":"Susan M","family":"Webb","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER, Unidad 747), Instituto de Salud Carlos III (ISCIII) , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Endocrinology and Nutrition, EndoERN, Research Center for Pituitary Diseases, Institut de Recerca Sant Pau (IIB-Sant Pau), Hospital Sant Pau , 08025 Barcelona ,","place":["Spain"]},{"name":"Departament of Medicine, Universitat Aut\u00f2noma de Barcelona (UAB) , 08193 Bellaterra ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Marazuela","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, La Princesa University Hospital , 28006 Madrid ,","place":["Spain"]},{"name":"Endocrine Research Unit, Instituto de Investigaci\u00f3n del Hospital de La Princesa , 28006 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-0105","authenticated-orcid":false,"given":"Elena","family":"Valassi","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Germans Trias I Pujol Research Institute (IGTP) , 08916 Badalona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER, Unidad 747), Instituto de Salud Carlos III (ISCIII) , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Endocrinology and Nutrition, Getafe University Hospital , 28905 Getafe ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-7195","authenticated-orcid":false,"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Germans Trias I Pujol Research Institute (IGTP) , 08916 Badalona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER, Unidad 747), Instituto de Salud Carlos III (ISCIII) , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Endocrinology and Nutrition, Getafe University Hospital , 28905 Getafe ,","place":["Spain"]},{"name":"Departament of Medicine, Universitat Aut\u00f2noma de Barcelona (UAB) , 08193 Bellaterra ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"issue":"14","key":"2026030605274838300_bvag030-B1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1056\/NEJM199004053221405","article-title":"Acromegaly","volume":"322","author":"Melmed","year":"1990","journal-title":"N Engl J Med"},{"issue":"4","key":"2026030605274838300_bvag030-B2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11154-020-09588-z","article-title":"Multidisciplinary management of acromegaly: a consensus","volume":"21","author":"Giustina","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"2026030605274838300_bvag030-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11102-020-01091-7","article-title":"A pituitary society update to acromegaly management guidelines","volume":"24","author":"Fleseriu","year":"2021","journal-title":"Pituitary"},{"issue":"9","key":"2026030605274838300_bvag030-B4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41574-018-0058-5","article-title":"A consensus statement on acromegaly therapeutic outcomes","volume":"14","author":"Melmed","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"2026030605274838300_bvag030-B5","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/jc.2014-2700","article-title":"Acromegaly: an endocrine society clinical practice guideline","volume":"99","author":"Katznelson","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026030605274838300_bvag030-B6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/cen.12731","article-title":"Treatment of acromegaly in the era of personalized and predictive medicine","volume":"83","author":"Puig Domingo","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2026030605274838300_bvag030-B7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.23736\/S0391-1977.18.02937-1","article-title":"Precision medicine in the treatment of acromegaly","volume":"44","author":"Puig-Domingo","year":"2019","journal-title":"Minerva Endocrinol"},{"issue":"6","key":"2026030605274838300_bvag030-B8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1530\/ERC-18-0565","article-title":"Molecular profiling for acromegaly treatment: a validation study","volume":"27","author":"Puig-Domingo","year":"2020","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"2026030605274838300_bvag030-B9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/ejendo\/lvae053","article-title":"Effectiveness of combined first-line medical treatment in acromegaly with prolactin cosecretion","volume":"190","author":"Biagetti","year":"2024","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"2026030605274838300_bvag030-B10","doi-asserted-by":"crossref","first-page":"102924","DOI":"10.1016\/j.arcmed.2023.102924","article-title":"Predictors of response to treatment with first-generation somatostatin receptor ligands in patients with acromegaly","volume":"54","author":"Marques-Pamies","year":"2023","journal-title":"Arch Med Res"},{"issue":"4","key":"2026030605274838300_bvag030-B11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4158\/EP-2018-0500","article-title":"Predictive markers for postsurgical medical management of acromegaly: a systematic review and consensus treatment guideline","volume":"25","author":"Ezzat","year":"2019","journal-title":"Endocr Pract"},{"issue":"1","key":"2026030605274838300_bvag030-B12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1210\/clinem\/dgae444","article-title":"Personalized medicine in acromegaly: the ACROFAST study","volume":"110","author":"Marques-Pamies","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2026030605274838300_bvag030-B13","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1210\/jc.2005-0260","article-title":"Long-acting somatostatin analog therapy of acromegaly: a meta-analysis","volume":"90","author":"Freda","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2026030605274838300_bvag030-B14","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1210\/jc.2005-2347","article-title":"Primary treatment of acromegaly with octreotide LAR: a long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor shrinkage","volume":"91","author":"Cozzi","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026030605274838300_bvag030-B15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.4158\/EP15913.RA","article-title":"Historical response rates of somatostatin analogues in the treatment of acromegaly: a systematic review","volume":"22","author":"Shanik","year":"2016","journal-title":"Endocr Pract"},{"issue":"1","key":"2026030605274838300_bvag030-B16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","article-title":"Acromegaly","volume":"5","author":"Colao","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"2026030605274838300_bvag030-B17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jval.2021.11.1351","article-title":"Consolidated health economic evaluation reporting standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations","volume":"25","author":"Husereau","year":"2022","journal-title":"Value Health"},{"issue":"3","key":"2026030605274838300_bvag030-B18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1210\/jc.2015-3653","article-title":"Pituitary medicine from discovery to patient-focused outcomes","volume":"101","author":"Melmed","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2026030605274838300_bvag030-B19","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.jval.2022.01.006","article-title":"The net benefit of personalized medicine: a systematic literature review and regression analysis","volume":"25","author":"Vellekoop","year":"2022","journal-title":"Value Health"},{"issue":"11","key":"2026030605274838300_bvag030-B20","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"2026030605274838300_bvag030-B21","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/pharmaceutics15020438","article-title":"Adherence to acromegaly treatment and analysis of the related factors-A real-world study in Bulgaria","volume":"15","author":"Kamusheva","year":"2023","journal-title":"Pharmaceutics"},{"issue":"10","key":"2026030605274838300_bvag030-B22","doi-asserted-by":"crossref","first-page":"bvad104","DOI":"10.1210\/jendso\/bvad104","article-title":"Treatment patterns, adherence, persistence, and health care resource utilization in acromegaly: a real-world analysis","volume":"7","author":"Fleseriu","year":"2023","journal-title":"J Endocr Soc"},{"issue":"6","key":"2026030605274838300_bvag030-B23","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.fertnstert.2018.05.006","article-title":"Personalized medicine: motivation, challenges, and progress","volume":"109","author":"Goetz","year":"2018","journal-title":"Fertil Steril"},{"issue":"9910","key":"2026030605274838300_bvag030-B24","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1016\/S0140-6736(13)62559-3","article-title":"Health technology assessment in universal health coverage","volume":"382","author":"Chalkidou","year":"2013","journal-title":"Lancet"},{"issue":"26","key":"2026030605274838300_bvag030-B25","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMp1011024","article-title":"What is value in health care?","volume":"363","author":"Porter","year":"2010","journal-title":"N Engl J Med"},{"key":"2026030605274838300_bvag030-B26","doi-asserted-by":"crossref","first-page":"1573721","DOI":"10.3389\/fendo.2025.1573721","article-title":"Cost-effectiveness analysis of second-line medical therapies in acromegaly: a real-life study","volume":"16","author":"Venegas Moreno","year":"2025","journal-title":"Front Endocrinol"},{"issue":"9","key":"2026030605274838300_bvag030-B27","doi-asserted-by":"crossref","first-page":"dgaa444","DOI":"10.1210\/clinem\/dgaa444","article-title":"Cost-effectiveness and efficacy of a novel combination regimen in acromegaly: a prospective, randomized trial","volume":"105","author":"Bonert","year":"2020","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/4\/bvag030\/67257278\/bvag030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/4\/bvag030\/67257278\/bvag030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:27:55Z","timestamp":1772792875000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvag030\/8509137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3,6]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvag030","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,6]]},"article-number":"bvag030"}}