{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:06:26Z","timestamp":1774933586116,"version":"3.50.1"},"reference-count":45,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD102060"],"award-info":[{"award-number":["R01 HD102060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 HL172130"],"award-info":[{"award-number":["R03 HL172130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 HD098319"],"award-info":[{"award-number":["K23 HD098319"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Hyperandrogenemia is associated with increased risks for metabolic syndrome in asymptomatic women and women with polycystic ovary syndrome. The relationship between hyperandrogenemia and metabolic syndrome in adolescent girls remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to assess whether free testosterone concentrations predict metabolic syndrome severity (MSS) in adolescent girls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/setting<\/jats:title>\n                    <jats:p>Using data from the U.S. National Health and Nutrition Examination Survey (2013-2016), we performed weighted regression analysis to evaluate whether free testosterone predicts MSS z-score after adjusting for body fat percentage, chronological age, and gynecological age. Similar analyses were performed using either total testosterone or sex hormone-binding globulin (SHBG) as the primary predictor variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>287 girls aged 12\u201319 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure<\/jats:title>\n                    <jats:p>MSS z-score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In simple regression analyses, free testosterone and percent body fat predicted MSS z-score (R2 = 0.11 and 0.35, respectively; P &amp;lt; .0001 for both), but chronological age and gynecological age did not. In the multivariable regression model (R2 = 0.41), higher free testosterone and percent body fat were independently associated with higher MSS z-score (P = .0081 and &amp;lt; .0001, respectively), with no significant independent associations with chronological age or gynecological age. While SHBG was an independent predictor of MSS z-score (P = .0104) in a multivariable regression model, total testosterone was not (P = .77).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher free testosterone predicts greater MSS in a nationally representative sample of adolescent girls aged 12\u201319 years. This relationship at least partly reflects the relationship between MSS z-score and SHBG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag055","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:37:23Z","timestamp":1773146243000},"source":"Crossref","is-referenced-by-count":0,"title":["Free testosterone independently predicts metabolic syndrome severity in U.S. adolescent girls aged 12\u201319 years"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-4982","authenticated-orcid":false,"given":"Christopher R","family":"McCartney","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, West Virginia University , Morgantown, WV 26506 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-2700","authenticated-orcid":false,"given":"Aaron 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