{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:02:03Z","timestamp":1776783723035,"version":"3.51.2"},"reference-count":49,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP25gn0110085"],"award-info":[{"award-number":["JP25gn0110085"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP24gn0110069"],"award-info":[{"award-number":["JP24gn0110069"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP25gk0210039"],"award-info":[{"award-number":["JP25gk0210039"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP24lk0310083"],"award-info":[{"award-number":["JP24lk0310083"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP25gn0110097"],"award-info":[{"award-number":["JP25gn0110097"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP25gk0210042"],"award-info":[{"award-number":["JP25gk0210042"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP25gk0210045"],"award-info":[{"award-number":["JP25gk0210045"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Children and Families Agency"},{"name":"JSPS KAKENHI","award":["JP25H01065"],"award-info":[{"award-number":["JP25H01065"]}]},{"name":"JSPS KAKENHI","award":["JP24K21911"],"award-info":[{"award-number":["JP24K21911"]}]},{"name":"JSPS KAKENHI","award":["JP25K02779"],"award-info":[{"award-number":["JP25K02779"]}]},{"name":"JSPS KAKENHI","award":["JP24K22157"],"award-info":[{"award-number":["JP24K22157"]}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020964","name":"Fusion-Oriented Research for Disruptive Science and Technology","doi-asserted-by":"publisher","award":["JPMJFR210H"],"award-info":[{"award-number":["JPMJFR210H"]}],"id":[{"id":"10.13039\/501100020964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological interventions in certain cases\u2014particularly those resistant to hormone therapies\u2014underscores the urgent need for deeper mechanistic insights and the development of novel therapeutic strategies. Progress in this field, however, has been hampered by the scarcity of suitable experimental models, as adenomyosis is primarily a human disease. In this study, we demonstrate a preclinical platform for therapeutic evaluation using a mouse model of mechanically induced adenomyosis, which recapitulates the key pathological features observed in humans. By integrating high-resolution three-dimensional (3D) tissue imaging, we successfully visualized the invagination and expansion of adenomyosis lesions spatiotemporally. This approach enabled the clear-cut and efficient assessment of progestin efficacy in situ. We propose that the combination of a mechanistically relevant mouse model and advanced 3D histological analysis constitutes a concise and robust system for therapeutic validation and compound screening, thereby facilitating the discovery of effective treatments for adenomyosis.<\/jats:p>","DOI":"10.1210\/jendso\/bvag056","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:05:55Z","timestamp":1773803155000},"source":"Crossref","is-referenced-by-count":0,"title":["Three-dimensional characterization of adenomyosis in female mice: Toward a novel system for drug efficacy evaluation"],"prefix":"10.1210","volume":"10","author":[{"given":"Chihiro","family":"Ishizawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4030-3278","authenticated-orcid":false,"given":"Takehiro","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizu","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueting","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamato","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunori","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Makabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gentaro","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Wada-Hiraike","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-9780","authenticated-orcid":false,"given":"Yasushi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo , Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"issue":"1","key":"2026042109562618000_bvag056-B1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.xfnr.2022.11.004","article-title":"How does adenomyosis impact endometrial receptivity? An updated systematic review of clinical and molecular insights","volume":"4","author":"Hiraoka","year":"2023","journal-title":"F&S Rev"},{"issue":"3","key":"2026042109562618000_bvag056-B2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3390\/ijerph18031235","article-title":"Adenomyosis and infertility\u2014review of medical and surgical approaches","volume":"18","author":"Szubert","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"2026042109562618000_bvag056-B3","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/s43032-022-01077-9","article-title":"Levonorgestrel-releasing intrauterine system improves menorrhagia-related quality of life in patients with symptomatic adenomyosis","volume":"30","author":"Ishizawa","year":"2023","journal-title":"Reprod Sci"},{"issue":"19","key":"2026042109562618000_bvag056-B4","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.3390\/ijerph18199941","article-title":"Uterine adenomyosis: from disease pathogenesis to a new medical approach using GnRH antagonists","volume":"18","author":"Donnez","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"2026042109562618000_bvag056-B5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/cells11040647","article-title":"Progesterone actions and resistance in gynecological disorders","volume":"11","author":"MacLean","year":"2022","journal-title":"Cells"},{"issue":"15","key":"2026042109562618000_bvag056-B6","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.3390\/ijms20153822","article-title":"Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?","volume":"20","author":"Marquardt","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"10","key":"2026042109562618000_bvag056-B7","doi-asserted-by":"crossref","first-page":"e0165347","DOI":"10.1371\/journal.pone.0165347","article-title":"Progesterone alleviates endometriosis via inhibition of uterine cell proliferation, inflammation and angiogenesis in an immunocompetent mouse model","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"2026042109562618000_bvag056-B8","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.fertnstert.2009.01.084","article-title":"Immunoreactivity of progesterone receptor isoform B, nuclear factor \u03baB, and I\u03baB\u03b1 in adenomyosis","volume":"92","author":"Nie","year":"2009","journal-title":"Fertil Steril"},{"issue":"4","key":"2026042109562618000_bvag056-B9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/humupd\/dmaa009","article-title":"Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure","volume":"26","author":"Reis","year":"2020","journal-title":"Hum Reprod Update"},{"issue":"5","key":"2026042109562618000_bvag056-B10","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.fertnstert.2023.03.006","article-title":"Endometriosis and adenomyosis: shared pathophysiology","volume":"119","author":"Bulun","year":"2023","journal-title":"Fertil Steril"},{"issue":"6","key":"2026042109562618000_bvag056-B11","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/humupd\/dmab017","article-title":"Adenomyosis pathogenesis: insights from next-generation sequencing","volume":"27","author":"Bulun","year":"2021","journal-title":"Hum Reprod Update"},{"issue":"4","key":"2026042109562618000_bvag056-B12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.fertnstert.2023.06.004","article-title":"Local intraendometrial estrogen biosynthesis leading to progesterone resistance impacts implantation in adenomyosis and endometriosis","volume":"120","author":"Humaidan","year":"2023","journal-title":"Fertil Steril"},{"issue":"5","key":"2026042109562618000_bvag056-B13","doi-asserted-by":"crossref","first-page":"e240019","DOI":"10.1530\/REP-24-0019","article-title":"Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances","volume":"167","author":"Squatrito","year":"2024","journal-title":"Reproduction"},{"issue":"17","key":"2026042109562618000_bvag056-B14","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s40265-023-01957-7","article-title":"Current medical therapy for adenomyosis: from bench to bedside","volume":"83","author":"Etrusco","year":"2023","journal-title":"Drugs"},{"issue":"2","key":"2026042109562618000_bvag056-B15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tjog.2012.04.008","article-title":"Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist: long-term follow-up in a series of nine patients","volume":"51","author":"Huang","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"4-5","key":"2026042109562618000_bvag056-B16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.etp.2004.10.001","article-title":"Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer","volume":"56","author":"Green","year":"2005","journal-title":"Exp Toxicol Pathol"},{"issue":"2","key":"2026042109562618000_bvag056-B17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1530\/REP-09-0054","article-title":"The effects of tamoxifen and estradiol on myometrial differentiation and organization during early uterine development in the CD1 mouse","volume":"138","author":"Mehasseb","year":"2009","journal-title":"Reproduction"},{"issue":"2","key":"2026042109562618000_bvag056-B18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0002-9440(10)61733-6","article-title":"Adenomyosis\u2013a result of disordered stromal differentiation","volume":"159","author":"Parrott","year":"2001","journal-title":"Am J Pathol"},{"issue":"1","key":"2026042109562618000_bvag056-B19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000145724","article-title":"Mechanisms of development of prolactin-induced adenomyosis in mice","volume":"116","author":"Mori","year":"1983","journal-title":"Acta Anat (Basel)"},{"issue":"1","key":"2026042109562618000_bvag056-B20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0002-9378(91)90258-S","article-title":"Animal model of uterine adenomyosis: is prolactin a potent inducer of adenomyosis in mice?","volume":"165","author":"Mori","year":"1991","journal-title":"Am J Obstet Gynecol"},{"issue":"2\/03","key":"2026042109562618000_bvag056-B21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/s-0040-1718922","article-title":"Pathology and pathogenesis of adenomyosis","volume":"38","author":"Antero","year":"2020","journal-title":"Semin Reprod Med"},{"issue":"8","key":"2026042109562618000_bvag056-B22","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s43032-020-00361-w","article-title":"Origin and pathogenic mechanisms of uterine adenomyosis: what is known so far","volume":"28","author":"Stratopoulou","year":"2021","journal-title":"Reprod Sci"},{"issue":"2","key":"2026042109562618000_bvag056-B23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/HMBCI.2011.002","article-title":"A new concept of endometriosis and adenomyosis: tissue injury and repair (TIAR)","volume":"5","author":"Leyendecker","year":"2011","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"4","key":"2026042109562618000_bvag056-B24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00404-009-1191-0","article-title":"The pathophysiology of endometriosis and adenomyosis: tissue injury and repair","volume":"280","author":"Leyendecker","year":"2009","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"2026042109562618000_bvag056-B25","doi-asserted-by":"crossref","first-page":"114.e1\u2013","DOI":"10.1016\/j.ajog.2012.06.027","article-title":"Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification","volume":"207","author":"Kishi","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"2026042109562618000_bvag056-B26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/jcm9020485","article-title":"The pathogenesis of adenomyosis vis-\u00e0-vis endometriosis","volume":"9","author":"Guo","year":"2020","journal-title":"J Clin Med"},{"issue":"5","key":"2026042109562618000_bvag056-B27","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1530\/REP-22-0224","article-title":"Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology","volume":"164","author":"Guo","year":"2022","journal-title":"Reproduction"},{"issue":"5","key":"2026042109562618000_bvag056-B28","doi-asserted-by":"crossref","first-page":"bqac044","DOI":"10.1210\/endocr\/bqac044","article-title":"Constant activation of STAT3 contributes to the development of adenomyosis in females","volume":"163","author":"Hiraoka","year":"2022","journal-title":"Endocrinology"},{"issue":"3","key":"2026042109562618000_bvag056-B29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00404-016-4105-y","article-title":"Relationship between uterine volume and discontinuation of treatment with levonorgestrel-releasing intrauterine devices in patients with adenomyosis","volume":"294","author":"Lee","year":"2016","journal-title":"Arch Gynecol Obstet"},{"issue":"21","key":"2026042109562618000_bvag056-B30","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.21037\/atm-20-3420","article-title":"Efficacy of the levonorgestrel-releasing intrauterine device is associated with different subtypes of adenomyosis: a retrospective study","volume":"8","author":"Chen","year":"2020","journal-title":"Ann Transl Med"},{"key":"2026042109562618000_bvag056-B31","doi-asserted-by":"crossref","first-page":"1550814","DOI":"10.3389\/frph.2025.1550814","article-title":"Risk factors and countermeasures for abnormal uterine bleeding during dienogest therapy for adenomyosis: a review","volume":"7","author":"Zhang","year":"2025","journal-title":"Front Reprod Health"},{"issue":"4","key":"2026042109562618000_bvag056-B32","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/jog.14612","article-title":"Evaluating the safety of dienogest in women with adenomyosis: a retrospective analysis","volume":"47","author":"Ono","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"2026042109562618000_bvag056-B33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41467-018-03092-4","article-title":"Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation","volume":"9","author":"Yuan","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"2026042109562618000_bvag056-B34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41420-024-02228-4","article-title":"Spatiotemporal functions of leukemia inhibitory factor in embryo attachment and implantation chamber formation","volume":"10","author":"Aikawa","year":"2024","journal-title":"Cell Death Discov"},{"issue":"11","key":"2026042109562618000_bvag056-B35","doi-asserted-by":"crossref","first-page":"bqab169","DOI":"10.1210\/endocr\/bqab169","article-title":"Uterine epithelial LIF receptors contribute to implantation chamber formation in blastocyst attachment","volume":"162","author":"Fukui","year":"2021","journal-title":"Endocrinology"},{"issue":"5","key":"2026042109562618000_bvag056-B36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41419-023-05832-x","article-title":"The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion","volume":"14","author":"Fukui","year":"2023","journal-title":"Cell Death Dis"},{"issue":"1","key":"2026042109562618000_bvag056-B37","doi-asserted-by":"crossref","first-page":"17515","DOI":"10.1038\/s41598-022-22413-8","article-title":"Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies","volume":"12","author":"Elsherbini","year":"2022","journal-title":"Sci Rep"},{"issue":"7","key":"2026042109562618000_bvag056-B38","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.ajpath.2014.03.011","article-title":"A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium","volume":"184","author":"Greaves","year":"2014","journal-title":"Am J Pathol"},{"issue":"2","key":"2026042109562618000_bvag056-B39","doi-asserted-by":"crossref","first-page":"bqz005","DOI":"10.1210\/endocr\/bqz005","article-title":"Levonorgestrel inhibits embryo attachment by eliminating uterine induction of leukemia inhibitory factor","volume":"161","author":"Matsuo","year":"2020","journal-title":"Endocrinology"},{"issue":"2","key":"2026042109562618000_bvag056-B40","doi-asserted-by":"crossref","first-page":"e50927","DOI":"10.15252\/embr.202050927","article-title":"Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion","volume":"22","author":"Akaeda","year":"2021","journal-title":"EMBO Rep"},{"issue":"4","key":"2026042109562618000_bvag056-B41","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.rbmo.2017.12.018","article-title":"Dienogest suppresses the activation of primordial follicles and preserves the primordial follicle stockpile for fertility in mice","volume":"36","author":"Zheng","year":"2018","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"2026042109562618000_bvag056-B42","doi-asserted-by":"crossref","first-page":"102258","DOI":"10.1016\/j.isci.2021.102258","article-title":"Three-dimensional understanding of the morphological complexity of the human uterine endometrium","volume":"24","author":"Yamaguchi","year":"2021","journal-title":"iScience"},{"issue":"11","key":"2026042109562618000_bvag056-B43","doi-asserted-by":"crossref","first-page":"e50167","DOI":"10.1371\/journal.pone.0050167","article-title":"Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1beta-induced COX-2 expression in human term myometrial cells","volume":"7","author":"Lei","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"2026042109562618000_bvag056-B44","doi-asserted-by":"crossref","first-page":"e87591","DOI":"10.1172\/jci.insight.87591","article-title":"STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation","volume":"1","author":"Hiraoka","year":"2016","journal-title":"JCI Insight"},{"issue":"7193","key":"2026042109562618000_bvag056-B45","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"issue":"7541","key":"2026042109562618000_bvag056-B46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14228","article-title":"A gp130-Src-YAP module links inflammation to epithelial regeneration","volume":"519","author":"Taniguchi","year":"2015","journal-title":"Nature"},{"issue":"8","key":"2026042109562618000_bvag056-B47","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/eji.201646710","article-title":"The IL-10\/STAT3 axis: contributions to immune tolerance by thymus and peripherally derived regulatory T-cells","volume":"47","author":"Schmetterer","year":"2017","journal-title":"Eur J Immunol"},{"key":"2026042109562618000_bvag056-B48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"2026042109562618000_bvag056-B49","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12958-021-00764-7","article-title":"Effects of localisation of uterine adenomyosis on outcome of in vitro fertilisation\/intracytoplasmic sperm injection fresh and frozen-thawed embryo transfer cycles: a multicentre retrospective cohort study","volume":"19","author":"Iwasawa","year":"2021","journal-title":"Reprod Biol Endocrinol"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvag056\/67385635\/bvag056.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/5\/bvag056\/67385635\/bvag056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/5\/bvag056\/67385635\/bvag056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:56:41Z","timestamp":1776779801000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvag056\/8526990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,4,7]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvag056","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,3,17]]},"article-number":"bvag056"}}