{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:32:36Z","timestamp":1792481556681,"version":"4.5.0"},"reference-count":27,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802700"],"award-info":[{"award-number":["2024YFA1802700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ30915"],"award-info":[{"award-number":["2023JJ30915"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ20089"],"award-info":[{"award-number":["2025JJ20089"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170806"],"award-info":[{"award-number":["82170806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Head and neck paragangliomas (HNPGLs) are tumors of parasympathetic origin, predominantly associated with pseudohypoxia and pathogenic variants (PVs) in succinate dehydrogenase (SDH) subunits, mainly based on studies in Europeans\/Americans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to assess the genetics of HNPGLs in a large Chinese cohort and compare them with European cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted of HNPGLs from 2 Chinese tertiary-care centers and 2 European centers. Participants included 222 Chinese and 205 European HNPGL patients. Main outcome measures included clinical presentation and genetic status assessed via next-generation sequencing of tumor\/blood samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Chinese HNPGL cohort consisted mainly of carotid body HNPGLs (86.9%), fewer jugulotympanic (12.2%), and no vagal HNPGLs. Jugulotympanic HNPGLs showed higher recurrence than carotid body HNPGLs (30.4% vs 8.5%; P = .009). PVs were detected in 62.2% of Chinese patients, predominantly in SDHx genes. PV frequency was higher in carotid body than jugulotympanic HNPGLs (65.8% vs 37%; P = .004), and in more male than female patients (75.9% vs 54.0%; P = .001). Compared to those without SDHx PVs, SDHx PVs carriers were younger (41.0 vs 49.0; P &amp;lt; .001), with more multifocal tumors (20.8% vs 7.6%; P = .007) and less often female (53.1% vs 76.1%; P &amp;lt; .001). Compared with Europeans, Chinese patients were younger (45.0 vs 54.3; P &amp;lt; .001), with fewer multilocal HNPGLs (0.9 vs 13.7%; P &amp;lt; .001), lower rates of recurrence (13.7% vs 28.0%; P = .007), but similar metastasis rates (3.9% vs 5.0%; P = .668).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first report of HNPGLs in a large Chinese cohort. Clinical presentation and practice as well as ancestry all likely contribute to the differences observed between Chinese and European patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag062","type":"journal-article","created":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T11:34:30Z","timestamp":1775993670000},"source":"Crossref","is-referenced-by-count":2,"title":["Clinical and genetic characteristics of head and neck paragangliomas from China featuring Sino-European comparisons"],"prefix":"10.1210","volume":"10","author":[{"given":"Jun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxian","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-5748","authenticated-orcid":false,"given":"Henri J L M","family":"Timmers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud University Medical Centre , 6525 GA Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Pamporaki","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henricus P M","family":"Kunst","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Dutch Academic Alliance Skull Base Pathology, Radboud University Medical Center , 6525 GA Nijmegen ,","place":["The Netherlands"]},{"name":"Department of Otorhinolaryngology, Dutch Academic Alliance Skull Base Pathology, Maastricht University Medical Center+ , 6229 HX Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0274-4057","authenticated-orcid":false,"given":"Longfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-6313","authenticated-orcid":false,"given":"Zhiqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-228X","authenticated-orcid":false,"given":"Zhiyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Richter","sequence":"additional","affiliation":[{"name":"Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland , Auckland 1142 ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1886-2613","authenticated-orcid":false,"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University , Shanghai 200032 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