{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:24:35Z","timestamp":1779877475686,"version":"3.53.1"},"reference-count":70,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["470608"],"award-info":[{"award-number":["470608"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["DG386445"],"award-info":[{"award-number":["DG386445"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSERC-CGS-D"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>N-(phosphonomethyl)glycine (glyphosate) is the most sprayed herbicidal chemical in the world. Although glyphosate is considered safe in humans and higher animals due to its targeting of the shikimate pathway found only in plants and microorganisms, recent in vivo and in vitro studies show evidence of toxicity across a range of systems, including the vertebrate brain. Given that developing brains with immature blood-brain barriers can be especially sensitive to environmental contaminants, here we test the effects of embryonic exposure to environmental levels of glyphosate or its commercial formulation, Roundup\u00ae. Embryonic zebrafish exposed to an environmental concentration of Roundup (10\u2005\u00b5g\/L acid equivalent) from 10 to 48\u2005hours postfertilization (hpf) showed defects in morphology, respiratory capacity, and hatching at 48 hpf as well as changes in locomotion, light-startle response, and thigmotaxis behaviors at 5 days postfertilization (dpf), with some effects lasting in the juvenile. To understand neurodevelopmental changes underlying these behavioral abnormalities, we tested for changes to the timing of neurogenesis and conducted bulk RNA sequencing. We found increased neurogenesis and uncovered dysregulation of axonogenesis pathways, which was confirmed using immunohistochemistry. Finally, to test if axonal deficits might manifest as dysregulation of neuronal circuits, we observed changes in phospho-extracellular signal-regulated kinases levels and Ca2+ dynamics as indicators of activity disruptions at 5 dpf following embryonic exposure to Roundup. These results suggest that Roundup at current environmental levels may not be safe for organismal exposure, and glyphosate toxicity warrants closer attention.<\/jats:p>","DOI":"10.1210\/jendso\/bvag067","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:46:17Z","timestamp":1774442777000},"source":"Crossref","is-referenced-by-count":1,"title":["Embryonic exposure to environmental levels of roundup affects neurodevelopment in zebrafish"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-8564","authenticated-orcid":false,"given":"Rachel","family":"Lacroix","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Almanza","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mataea","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-287X","authenticated-orcid":false,"given":"Deborah","family":"Kurrasch","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"2026042701265908500_bvag067-B1","first-page":"1","volume-title":"Glyphosate Resistance in Crops and Weeds","author":"Dill","year":"2010"},{"issue":"11","key":"2026042701265908500_bvag067-B2","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.3390\/foods10112785","article-title":"Glyphosate use, toxicity and occurrence in food","volume":"10","author":"Soares","year":"2021","journal-title":"Foods"},{"issue":"1","key":"2026042701265908500_bvag067-B3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12302-016-0070-0","article-title":"Trends in glyphosate herbicide use in the United States and globally","volume":"28","author":"Benbrook","year":"2016","journal-title":"Environ Sci Eur"},{"issue":"1","key":"2026042701265908500_bvag067-B4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/fee.1985","article-title":"The overlooked impact of rising glyphosate use on phosphorus loading in agricultural watersheds","volume":"17","author":"H\u00e9bert","year":"2019","journal-title":"Front Ecol Environ"},{"key":"2026042701265908500_bvag067-B5","author":"Henderson"},{"key":"2026042701265908500_bvag067-B6","doi-asserted-by":"crossref","first-page":"113380","DOI":"10.1016\/j.fct.2022.113380","article-title":"The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay","volume":"168","author":"Mesnage","year":"2022","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"2026042701265908500_bvag067-B7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/ijerph13030264","article-title":"Co-formulants in glyphosate-based herbicides disrupt aromatase activity in human cells below toxic levels","volume":"13","author":"Defarge","year":"2016","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"2026042701265908500_bvag067-B8","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0006-291X(80)90547-1","article-title":"The herbicide glyphosate is a potent inhibitor of 5-enolpyruvylshikimic acid-3-phosphate synthase","volume":"94","author":"Steinr\u00fccken","year":"1980","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2026042701265908500_bvag067-B9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.chemosphere.2010.06.067","article-title":"Relevance of urban glyphosate use for surface water quality","volume":"81","author":"Hanke","year":"2010","journal-title":"Chemosphere"},{"issue":"11","key":"2026042701265908500_bvag067-B10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3390\/plants8110499","article-title":"Glyphosate: its environmental persistence and impact on crop health and nutrition","volume":"8","author":"Kanissery","year":"2019","journal-title":"Plants"},{"issue":"6","key":"2026042701265908500_bvag067-B11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/jmse8060399","article-title":"The effects of glyphosate and its commercial formulations to marine invertebrates: a review","volume":"8","author":"Matozzo","year":"2020","journal-title":"J Mar Sci Eng"},{"key":"2026042701265908500_bvag067-B12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.envpol.2019.03.125","article-title":"Widespread occurrence and spatial distribution of glyphosate, atrazine, and neonicotinoids pesticides in the St. Lawrence and tributary rivers","volume":"250","author":"Montiel-Le\u00f3n","year":"2019","journal-title":"Environ Pollut"},{"issue":"11","key":"2026042701265908500_bvag067-B13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s10661-016-5627-2","article-title":"Effects of glyphosate at environmentally relevant concentrations on the growth of and microcystin production by Microcystis aeruginosa","volume":"188","author":"Zhang","year":"2016","journal-title":"Environ Monit Assess"},{"issue":"16","key":"2026042701265908500_bvag067-B14","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1001\/jama.2017.11726","article-title":"Excretion of the herbicide glyphosate in older adults between 1993 and 2016","volume":"318","author":"Mills","year":"2017","journal-title":"JAMA"},{"issue":"1","key":"2026042701265908500_bvag067-B15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12940-018-0435-5","article-title":"The evidence of human exposure to glyphosate: a review","volume":"18","author":"Gillezeau","year":"2019","journal-title":"Environ Health"},{"key":"2026042701265908500_bvag067-B16","doi-asserted-by":"crossref","first-page":"e12194","DOI":"10.1590\/1414-431x2022e12194","article-title":"Determination of glyphosate in breast milk of lactating women in a rural area from Paran\u00e1 state, Brazil","volume":"55","author":"Camiccia","year":"2022","journal-title":"Braz J Med Biol Res"},{"issue":"18","key":"2026042701265908500_bvag067-B17","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1021\/acs.jafc.9b07819","article-title":"Analysis of glyphosate residues in foods from the Canadian retail markets between 2015 and 2017","volume":"68","author":"Kolakowski","year":"2020","journal-title":"J Agric Food Chem"},{"issue":"8","key":"2026042701265908500_bvag067-B18","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/0265203031000109477","article-title":"Analysis of glyphosate residues in cereals using liquid chromatography-mass spectrometry (LC-MS\/MS)","volume":"20","author":"Granby","year":"2003","journal-title":"Food Addit Contam"},{"issue":"1","key":"2026042701265908500_bvag067-B19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12302-018-0184-7","article-title":"How did the US EPA and IARC reach diametrically opposed conclusions on the genotoxicity of glyphosate-based herbicides?","volume":"31","author":"Benbrook","year":"2019","journal-title":"Environ Sci Eur"},{"issue":"2","key":"2026042701265908500_bvag067-B20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/toxsci\/kfad018","article-title":"Glyphosate toxicity: in vivo, in vitro, and epidemiological evidence","volume":"192","author":"Lacroix","year":"2023","journal-title":"Toxicol Sci"},{"issue":"1","key":"2026042701265908500_bvag067-B21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12974-022-02544-5","article-title":"Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNF\u03b1: implications for neurodegenerative disorders","volume":"19","author":"Winstone","year":"2022","journal-title":"J Neuroinflammation"},{"key":"2026042701265908500_bvag067-B22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxlet.2018.12.013","article-title":"Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier","volume":"304","author":"Martinez","year":"2019","journal-title":"Toxicol Lett"},{"key":"2026042701265908500_bvag067-B23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.reprotox.2020.08.006","article-title":"Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway","volume":"96","author":"Coullery","year":"2020","journal-title":"Reprod Toxicol"},{"issue":"9","key":"2026042701265908500_bvag067-B24","doi-asserted-by":"crossref","first-page":"e12731","DOI":"10.1111\/jne.12731","article-title":"Glyphosate and glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome","volume":"31","author":"Dechartres","year":"2019","journal-title":"J Neuroendocrinol"},{"key":"2026042701265908500_bvag067-B25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuro.2014.12.001","article-title":"The herbicide glyphosate causes behavioral changes and alterations in dopaminergic markers in male Sprague-Dawley rat","volume":"46","author":"Hern\u00e1ndez-Plata","year":"2015","journal-title":"Neurotoxicology"},{"key":"2026042701265908500_bvag067-B26","doi-asserted-by":"crossref","first-page":"l962","DOI":"10.1136\/bmj.l962","article-title":"Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study","volume":"364","author":"von Ehrenstein","year":"2019","journal-title":"BMJ"},{"key":"2026042701265908500_bvag067-B27","doi-asserted-by":"crossref","first-page":"106477","DOI":"10.1016\/j.envint.2021.106477","article-title":"Exposure to multiple pesticides and neurobehavioral outcomes among smallholder farmers in Uganda","volume":"152","author":"Fuhrimann","year":"2021","journal-title":"Environ Int"},{"key":"2026042701265908500_bvag067-B28","doi-asserted-by":"crossref","first-page":"116860","DOI":"10.1016\/j.envres.2023.116860","article-title":"Association between glyphosate exposure and cognitive function, depression, and neurological diseases in a representative sample of US adults: NHANES 2013\u20132014 analysis","volume":"237","author":"Hsiao","year":"2023","journal-title":"Environ Res"},{"issue":"1","key":"2026042701265908500_bvag067-B29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12302-023-00758-9","article-title":"Terrestrial ecotoxicity of glyphosate, its formulations, and co-formulants: evidence from 2010\u20132023","volume":"35","author":"Kl\u00e1tyik","year":"2023","journal-title":"Environ Sci Eur"},{"issue":"8","key":"2026042701265908500_bvag067-B30","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/tox.23549","article-title":"Glyphosate-based herbicide induces long-lasting impairment in neuronal and glial differentiation","volume":"37","author":"Reis","year":"2022","journal-title":"Environ Toxicol"},{"key":"2026042701265908500_bvag067-B31","doi-asserted-by":"crossref","first-page":"153369","DOI":"10.1016\/j.tox.2022.153369","article-title":"Comparison of the effect of glyphosate and glyphosate-based herbicide on hippocampal neurogenesis after developmental exposure in rats","volume":"483","author":"Ojiro","year":"2023","journal-title":"Toxicology"},{"issue":"3","key":"2026042701265908500_bvag067-B32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev Dyn"},{"key":"2026042701265908500_bvag067-B33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-418669-9.00002-7","volume-title":"Atlas of Early Zebrafish Brain Development","author":"Mueller","year":"2016","edition":"2nd ed"},{"issue":"7","key":"2026042701265908500_bvag067-B34","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"9","key":"2026042701265908500_bvag067-B35","doi-asserted-by":"crossref","first-page":"e25652","DOI":"10.1371\/journal.pone.0025652","article-title":"Bioenergetic profiling of zebrafish embryonic development","volume":"6","author":"Stackley","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"2026042701265908500_bvag067-B36","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.1417731112","article-title":"Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish","volume":"112","author":"Kinch","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2026042701265908500_bvag067-B37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat Biotechnol"},{"issue":"8","key":"2026042701265908500_bvag067-B38","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinforma Oxf Engl"},{"issue":"5","key":"2026042701265908500_bvag067-B39","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol"},{"issue":"4","key":"2026042701265908500_bvag067-B40","first-page":"347","article-title":"Clonal analysis of olfaction in Drosophila: image registration","volume":"2013","author":"Ostrovsky","year":"2013","journal-title":"Cold Spring Harb Protoc"},{"issue":"1","key":"2026042701265908500_bvag067-B41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1109\/TITB.2003.808506","article-title":"Nonrigid image registration in shared-memory multiprocessor environments with application to brains, breasts, and bees","volume":"7","author":"Rohlfing","year":"2003","journal-title":"IEEE Trans Inf Technol Biomed"},{"issue":"11","key":"2026042701265908500_bvag067-B42","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nmeth.3581","article-title":"Whole-brain activity mapping onto a zebrafish brain atlas","volume":"12","author":"Randlett","year":"2015","journal-title":"Nat Methods"},{"issue":"22","key":"2026042701265908500_bvag067-B43","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1093\/bioinformatics\/btw413","article-title":"MorphoLibJ: integrated library and plugins for mathematical morphology with ImageJ","volume":"32","author":"Legland","year":"2016","journal-title":"Bioinformatics"},{"key":"2026042701265908500_bvag067-B44","unstructured":"Lacroix R, Almanza V, McKenzie S, Armstrong M, Kurrasch DM. Supplemental figures 1-3. Published online March 2026. doi:10.6084\/m9.figshare.31584445."},{"issue":"10","key":"2026042701265908500_bvag067-B45","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/03601234.2022.2115780","article-title":"Transcriptomic signaling in zebrafish (Danio rerio) embryos exposed to environmental concentrations of glyphosate","volume":"57","author":"Terrazas-Salgado","year":"2022","journal-title":"J Environ Sci Health Part B"},{"key":"2026042701265908500_bvag067-B46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fncir.2015.00039","article-title":"Development of social behavior in young zebrafish","volume":"9","author":"Dreosti","year":"2015","journal-title":"Front Neural Circuits"},{"key":"2026042701265908500_bvag067-B47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fcell.2019.00057","article-title":"Functional integration of newborn neurons in the zebrafish optic Tectum","volume":"7","author":"Boulanger-Weill","year":"2019","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"2026042701265908500_bvag067-B48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1749-4877.2008.00140.x","article-title":"Secondary neurogenesis and telencephalic organization in zebrafish and mice: a brief review","volume":"4","author":"Wullimann","year":"2009","journal-title":"Integr Zool"},{"issue":"1637","key":"2026042701265908500_bvag067-B49","doi-asserted-by":"crossref","first-page":"20120462","DOI":"10.1098\/rstb.2012.0462","article-title":"Zebrafish forebrain and temporal conditioning","volume":"369","author":"Cheng","year":"2014","journal-title":"Philos Trans R Soc B Biol Sci"},{"issue":"4","key":"2026042701265908500_bvag067-B50","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.bbrc.2019.04.074","article-title":"Glyphosate induces toxicity and modulates calcium and NO signaling in zebrafish embryos","volume":"513","author":"Gaur","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"2026042701265908500_bvag067-B51","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/etc.3580","article-title":"Ecotoxicological assessment of glyphosate-based herbicides: effects on different organisms","volume":"36","author":"de Brito Rodrigues","year":"2017","journal-title":"Environ Toxicol Chem"},{"issue":"8","key":"2026042701265908500_bvag067-B52","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s10646-022-02581-z","article-title":"Effects of glyphosate on zebrafish: a systematic review and meta-analysis","volume":"31","author":"Ames","year":"2022","journal-title":"Ecotoxicology"},{"issue":"12","key":"2026042701265908500_bvag067-B53","first-page":"12","article-title":"Effects of glyphosate or glyphosate-based herbicide during the zebrafish life cycle: a review addressing the mechanisms of toxicity","volume":"15","author":"Lanzarin","year":"2023","journal-title":"Water (Basel)"},{"key":"2026042701265908500_bvag067-B54","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.chemosphere.2019.02.071","article-title":"Dose-dependent effects of a glyphosate commercial formulation\u2014Roundup\u00ae UltraMax\u2014on the early zebrafish embryogenesis","volume":"223","author":"Lanzarin","year":"2019","journal-title":"Chemosphere"},{"key":"2026042701265908500_bvag067-B55","first-page":"183","article-title":"The effects of low-toxic herbicide Roundup and glyphosate on mitochondria","volume":"21","author":"Strilbyska","year":"2022","journal-title":"EXCLI J"},{"key":"2026042701265908500_bvag067-B56","doi-asserted-by":"crossref","first-page":"120314","DOI":"10.1016\/j.envpol.2022.120314","article-title":"Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells","volume":"314","author":"Lu","year":"2022","journal-title":"Environ Pollut"},{"key":"2026042701265908500_bvag067-B57","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fnbeh.2017.00146","article-title":"Behavioral and immunohistochemical study of the effects of subchronic and chronic exposure to glyphosate in mice","volume":"11","author":"Ait Bali","year":"2017","journal-title":"Front Behav Neurosci"},{"key":"2026042701265908500_bvag067-B58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2017.10.007","article-title":"Glyphosate and Roundup\u00ae alter morphology and behavior in zebrafish","volume":"392","author":"Bridi","year":"2017","journal-title":"Toxicology"},{"key":"2026042701265908500_bvag067-B59","doi-asserted-by":"crossref","first-page":"128986","DOI":"10.1016\/j.chemosphere.2020.128986","article-title":"Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae","volume":"267","author":"Forner-Piquer","year":"2021","journal-title":"Chemosphere"},{"issue":"2","key":"2026042701265908500_bvag067-B60","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1523\/JNEUROSCI.12-02-00467.1992","article-title":"Axonogenesis and morphogenesis in the embryonic zebrafish brain","volume":"12","author":"Ross","year":"1992","journal-title":"J Neurosci"},{"issue":"6","key":"2026042701265908500_bvag067-B61","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1523\/JNEUROSCI.10-06-01892.1990","article-title":"Axonogenesis in the brain of zebrafish embryos","volume":"10","author":"Chitnis","year":"1990","journal-title":"J Neurosci"},{"issue":"1","key":"2026042701265908500_bvag067-B62","doi-asserted-by":"crossref","first-page":"e06027","DOI":"10.1016\/j.heliyon.2021.e06027","article-title":"Changes in microtubule stability in zebrafish (Danio rerio) embryos after glyphosate exposure","volume":"7","author":"D\u00edaz-Mart\u00edn","year":"2021","journal-title":"Heliyon"},{"issue":"3","key":"2026042701265908500_bvag067-B63","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.tiv.2009.12.020","article-title":"Effects of Roundup and glyphosate formulations on intracellular transport, microtubules and actin filaments in Xenopus laevis melanophores","volume":"24","author":"Hedberg","year":"2010","journal-title":"Toxicol In Vitro"},{"issue":"6","key":"2026042701265908500_bvag067-B64","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0896-6273(94)90438-3","article-title":"Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras","volume":"12","author":"Rosen","year":"1994","journal-title":"Neuron"},{"issue":"8","key":"2026042701265908500_bvag067-B65","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/dneu.22364","article-title":"Impaired cortical neurogenesis in plexin-B1 and -B2 double deletion mutant","volume":"76","author":"Daviaud","year":"2016","journal-title":"Dev Neurobiol"},{"issue":"16","key":"2026042701265908500_bvag067-B66","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1523\/JNEUROSCI.4256-13.2014","article-title":"Robo1 modulates proliferation and neurogenesis in the developing neocortex","volume":"34","author":"Yeh","year":"2014","journal-title":"J Neurosci"},{"key":"2026042701265908500_bvag067-B67","doi-asserted-by":"crossref","first-page":"169271","DOI":"10.1016\/j.scitotenv.2023.169271","article-title":"Transcriptomic and behavioral analyses reveal unique target tissues and molecular pathways associated with embryonic exposure to low level glyphosate and metal mixtures in zebrafish","volume":"912","author":"Babich","year":"2024","journal-title":"Sci Total Environ"},{"issue":"12","key":"2026042701265908500_bvag067-B68","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/16040","article-title":"Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity","volume":"2","author":"Ji","year":"1999","journal-title":"Nat Neurosci"},{"key":"2026042701265908500_bvag067-B69","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tox.2014.03.001","article-title":"Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: involvement of glutamate excitotoxicity","volume":"320","author":"Cattani","year":"2014","journal-title":"Toxicology"},{"issue":"1","key":"2026042701265908500_bvag067-B70","doi-asserted-by":"crossref","first-page":"13655","DOI":"10.1038\/s41598-022-17537-w","article-title":"Roundup and glyphosate's impact on GABA to elicit extended proconvulsant behavior in Caenorhabditis elegans","volume":"12","author":"Naraine","year":"2022","journal-title":"Sci Rep"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvag067\/67574727\/bvag067.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/5\/bvag067\/67574727\/bvag067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/5\/bvag067\/67574727\/bvag067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:27:10Z","timestamp":1777267630000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvag067\/8544675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,4,7]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvag067","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,3,26]]},"article-number":"bvag067"}}