{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:46:35Z","timestamp":1775677595002,"version":"3.50.1"},"reference-count":51,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tufts Institute for Global Obesity Research pilot award"},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R00HD062841"],"award-info":[{"award-number":["R00HD062841"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD091735"],"award-info":[{"award-number":["R01HD091735"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12AR084217"],"award-info":[{"award-number":["K12AR084217"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MetroHealth Clinical and Transitional Science Collaborative","award":["RR024989"],"award-info":[{"award-number":["RR024989"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fetal fat accumulation is an important indicator of the nutritional environment in pregnancy and placental function. Excessive fat accretion leading to high adiposity at birth, however, can increase a child's long-term risk for obesity and metabolic disease. While maternal body mass index is associated with neonatal adiposity, there is a wide variation in body composition among babies born to women with and without obesity. The placenta orchestrates a complex exchange of nutrients and signals between the mother and baby. To better understand the molecular mechanisms that govern fetal fat accumulation, we profiled the transcriptomics of 79 placentas collected from mothers with and without obesity. We identified a set of 18 neonatal adiposity-associated genes, common to pregnancies with and without obesity. A coexpressed cluster of these genes is involved in innate immune responses, particularly neutrophil activation. We also identified neonatal adiposity-associated genes unique to mothers with or without obesity, suggesting different biological pathways support high newborn adiposity, and\/or are responsive to a common initial immune signal. These findings suggest that placental inflammation may influence fetal fat accumulation. Understanding these pathways may help identify novel ways to support healthy fetal growth and reduce the risk of long-term disease.<\/jats:p>","DOI":"10.1210\/jendso\/bvag071","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:38:27Z","timestamp":1774957107000},"source":"Crossref","is-referenced-by-count":0,"title":["Placental gene signatures associated with high neonatal adiposity: role for immune cell activation"],"prefix":"10.1210","volume":"10","author":[{"given":"Jason","family":"Laird","sequence":"first","affiliation":[{"name":"Department of Environmental Health and Engineering, Johns Hopkins University , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Woman, Mother + Baby Research Institute, Tufts Medicine , Boston, MA 02111 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Yen","sequence":"additional","affiliation":[{"name":"Woman, Mother + Baby Research Institute, Tufts Medicine , Boston, MA 02111 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Liu","sequence":"additional","affiliation":[{"name":"Woman, Mother + Baby Research Institute, Tufts Medicine , Boston, MA 02111 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-3034","authenticated-orcid":false,"given":"Patrick","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Mass General Brigham , Boston, MA 02115 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggero","family":"Spadafora","sequence":"additional","affiliation":[{"name":"Woman, Mother + Baby Research Institute, Tufts Medicine , Boston, MA 02111 ,","place":["USA"]},{"name":"Department of Pediatrics, Tufts University School of Medicine , Boston, MA 02111 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-9793","authenticated-orcid":false,"given":"Nanguneri","family":"Nirmala","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Medicine , Boston, MA 02111 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-4874","authenticated-orcid":false,"given":"Perrie","family":"O\u2019Tierney-Ginn","sequence":"additional","affiliation":[{"name":"Woman, Mother + Baby Research Institute, Tufts Medicine , Boston, MA 02111 ,","place":["USA"]},{"name":"Department of Obstetrics & Gynecology, Tufts University School of Medicine , Boston, MA 02111 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"issue":"2","key":"2026040814495695600_bvag071-B1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ajhb.20979","article-title":"Brains versus brawn: an empirical test of Barker's brain sparing model","volume":"22","author":"Baker","year":"2010","journal-title":"Am J Hum Biol"},{"issue":"8663","key":"2026040814495695600_bvag071-B2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease","volume":"334","author":"Barker","year":"1989","journal-title":"Lancet"},{"issue":"2","key":"2026040814495695600_bvag071-B3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1055\/s-2002-20518","article-title":"Size at birth, fat-free mass and resting metabolic rate in adult life","volume":"34","author":"Eriksson","year":"2002","journal-title":"Horm Metab Res"},{"issue":"2","key":"2026040814495695600_bvag071-B4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s001250050086","article-title":"Thinness at birth and insulin resistance in adult life","volume":"37","author":"Phillips","year":"1994","journal-title":"Diabetologia"},{"issue":"6","key":"2026040814495695600_bvag071-B5","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0002-9378(03)00828-7","article-title":"Increased fetal adiposity: a very sensitive marker of abnormal in utero development","volume":"189","author":"Catalano","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"2026040814495695600_bvag071-B6","doi-asserted-by":"crossref","first-page":"e20200737","DOI":"10.1542\/peds.2020-0737","article-title":"Neonatal adiposity and childhood obesity","volume":"146","author":"Moore","year":"2020","journal-title":"Pediatrics"},{"issue":"6","key":"2026040814495695600_bvag071-B7","doi-asserted-by":"crossref","first-page":"E540","DOI":"10.1152\/ajpendo.00356.2021","article-title":"Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI","volume":"322","author":"Aydogan Mathyk","year":"2022","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"2026040814495695600_bvag071-B8","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.ajog.2006.06.014","article-title":"Increased neonatal fat mass, not lean body mass, is associated with maternal obesity","volume":"195","author":"Sewell","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"2026040814495695600_bvag071-B9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/ppe.12682","article-title":"The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity","volume":"35","author":"Lima","year":"2021","journal-title":"Paediatr Perinat Epidemiol"},{"key":"2026040814495695600_bvag071-B10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fgene.2019.00354","article-title":"A co-expression analysis of the placental transcriptome in association with maternal pre-pregnancy BMI and newborn birth weight","volume":"10","author":"Cox","year":"2019","journal-title":"Front Genet"},{"issue":"3","key":"2026040814495695600_bvag071-B11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.placenta.2014.01.003","article-title":"Maternal obesity is associated with a lipotoxic placental environment","volume":"35","author":"Saben","year":"2014","journal-title":"Placenta"},{"issue":"5","key":"2026040814495695600_bvag071-B12","doi-asserted-by":"crossref","first-page":"647.e1","DOI":"10.1016\/j.ajog.2015.02.026","article-title":"Identification of early transcriptome signatures in placenta exposed to insulin and obesity","volume":"212","author":"Lassance","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"2026040814495695600_bvag071-B13","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/0002-9378(95)91348-3","article-title":"Anthropometric estimation of neonatal body composition","volume":"173","author":"Catalano","year":"1995","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"2026040814495695600_bvag071-B14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"3","key":"2026040814495695600_bvag071-B15","first-page":"100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"2026040814495695600_bvag071-B16"},{"issue":"3","key":"2026040814495695600_bvag071-B17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1101\/gr.207597.116","article-title":"Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface","volume":"27","author":"Pavli\u010dev","year":"2017","journal-title":"Genome Res"},{"issue":"1","key":"2026040814495695600_bvag071-B18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/pro.3987","article-title":"The human protein atlas-spatial localization of the human proteome in health and disease","volume":"30","author":"Digre","year":"2021","journal-title":"Protein Sci"},{"key":"2026040814495695600_bvag071-B19","unstructured":"O\u2019tierney-Ginn PF . Placental gene signatures associated with high neonatal adiposity: role for immune cell activation. Harvard Dataverse \u00a02026. 10.7910\/DVN\/4ZOMAR."},{"issue":"7","key":"2026040814495695600_bvag071-B20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.it.2019.04.013","article-title":"The neutrophil life cycle","volume":"40","author":"Hidalgo","year":"2019","journal-title":"Trends Immunol"},{"issue":"3","key":"2026040814495695600_bvag071-B21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1710-1492-2-3-98","article-title":"Mechanisms of degranulation in neutrophils","volume":"2","author":"Lacy","year":"2006","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1-2","key":"2026040814495695600_bvag071-B22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/19336918.2016.1148866","article-title":"Neutrophil migration into the placenta: good, bad or deadly?","volume":"10","author":"Giaglis","year":"2016","journal-title":"Cell Adh Migr"},{"key":"2026040814495695600_bvag071-B23","doi-asserted-by":"crossref","first-page":"104739","DOI":"10.1016\/j.ebiom.2023.104739","article-title":"Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice","volume":"95","author":"Zhang","year":"2023","journal-title":"EBioMedicine"},{"issue":"2","key":"2026040814495695600_bvag071-B24","first-page":"33","article-title":"Myeloperoxidase as an active disease biomarker: recent biochemical and pathological perspectives","volume":"6","author":"Khan","year":"2018","journal-title":"Med Sci (Basel)"},{"issue":"8","key":"2026040814495695600_bvag071-B25","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/en.2017-00152","article-title":"Effect of maternal obesity on placental lipid metabolism","volume":"158","author":"Calabuig-Navarro","year":"2017","journal-title":"Endocrinology"},{"issue":"11","key":"2026040814495695600_bvag071-B26","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.2337\/dc12-0614","article-title":"Myeloperoxidase is an early biomarker of inflammation and cardiovascular risk in prepubertal obese children","volume":"35","author":"Olza","year":"2012","journal-title":"Diabetes Care"},{"issue":"1","key":"2026040814495695600_bvag071-B27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13578-024-01322-5","article-title":"Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery","volume":"14","author":"Ren","year":"2024","journal-title":"Cell Biosci"},{"issue":"1","key":"2026040814495695600_bvag071-B28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ijo.2014.194","article-title":"Obesity is associated with more activated neutrophils in African American male youth","volume":"39","author":"Xu","year":"2015","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"2026040814495695600_bvag071-B29","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cmet.2013.03.005","article-title":"Imbalance between neutrophil elastase and its inhibitor \u03b11-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure","volume":"17","author":"Mansuy-Aubert","year":"2013","journal-title":"Cell Metab"},{"issue":"12","key":"2026040814495695600_bvag071-B30","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.3390\/cells11121883","article-title":"Neutrophils actively contribute to obesity-associated inflammation and pathological complications","volume":"11","author":"Uribe-Querol","year":"2022","journal-title":"Cells"},{"issue":"11","key":"2026040814495695600_bvag071-B31","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.4049\/jimmunol.1700253","article-title":"IL-20 signaling in activated human neutrophils inhibits neutrophil migration and function","volume":"198","author":"Gough","year":"2017","journal-title":"J Immunol"},{"issue":"3","key":"2026040814495695600_bvag071-B32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.numecd.2009.03.006","article-title":"Interleukin-20 circulating levels in obese women: effect of weight loss","volume":"20","author":"Maiorino","year":"2010","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"2026040814495695600_bvag071-B33","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/imm.13403","article-title":"IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation","volume":"164","author":"Hsu","year":"2021","journal-title":"Immunology"},{"issue":"1","key":"2026040814495695600_bvag071-B34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12865-017-0214-z","article-title":"Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands","volume":"18","author":"Pilling","year":"2017","journal-title":"BMC Immunol"},{"issue":"22","key":"2026040814495695600_bvag071-B35","doi-asserted-by":"crossref","first-page":"12390","DOI":"10.3390\/ijms252212390","article-title":"Role of balanced involvement of the ICOS\/ICOSL\/osteopontin network in cutaneous wound healing","volume":"25","author":"Christaki","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2026040814495695600_bvag071-B36","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/hmg\/ddp041","article-title":"Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden","volume":"18","author":"Renstr\u00f6m","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"10","key":"2026040814495695600_bvag071-B37","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.earlhumdev.2013.07.028","article-title":"Fetal and maternal factors associated with neonatal adiposity as measured by air displacement plethysmography: a large cross-sectional study","volume":"89","author":"Au","year":"2013","journal-title":"Early Hum Dev"},{"issue":"3","key":"2026040814495695600_bvag071-B38","doi-asserted-by":"crossref","first-page":"292.e1","DOI":"10.1016\/j.ajog.2014.05.031","article-title":"Sex-specific effects of maternal anthropometrics on body composition at birth","volume":"211","author":"O\u2019Tierney-Ginn","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"2026040814495695600_bvag071-B39","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2337\/db13-1094","article-title":"T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance","volume":"63","author":"Zhong","year":"2014","journal-title":"Diabetes"},{"key":"2026040814495695600_bvag071-B40","doi-asserted-by":"crossref","first-page":"2042018820930902","DOI":"10.1177\/2042018820930902","article-title":"Adipose tissue gene expression of CXCL10 and CXCL11 modulates inflammatory markers in obesity: implications for metabolic inflammation and insulin resistance","volume":"11","author":"Kochumon","year":"2020","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"10","key":"2026040814495695600_bvag071-B41","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1055\/a-1909-1922","article-title":"Association of blood lipocalin-2 levels with gestational diabetes mellitus: a systematic review and meta-analysis","volume":"54","author":"Zhu","year":"2022","journal-title":"Horm Metab Res"},{"issue":"2","key":"2026040814495695600_bvag071-B42","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease","volume":"75","author":"Raffetto","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"2026040814495695600_bvag071-B43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/bs.pmbts.2017.04.001","article-title":"Matrix metalloproteinases in normal pregnancy and preeclampsia","volume":"148","author":"Chen","year":"2017","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"2","key":"2026040814495695600_bvag071-B44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.MCHD-0002-2015","article-title":"Metalloproteinases: a functional pathway for myeloid cells","volume":"4","author":"Chou","year":"2016","journal-title":"Microbiol Spectr"},{"issue":"32","key":"2026040814495695600_bvag071-B45","doi-asserted-by":"crossref","first-page":"23603","DOI":"10.1074\/jbc.M701120200","article-title":"The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)","volume":"282","author":"Sachs","year":"2007","journal-title":"J Biol Chem"},{"issue":"2","key":"2026040814495695600_bvag071-B46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/MED.0000000000000136","article-title":"Apolipoprotein C-III: a potent modulator of hypertriglyceridemia and cardiovascular disease","volume":"22","author":"Kohan","year":"2015","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"2","key":"2026040814495695600_bvag071-B47","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/jcmm.13369","article-title":"Leptin action in normal and pathological pregnancies","volume":"22","author":"P\u00e9rez-P\u00e9rez","year":"2018","journal-title":"J Cell Mol Med"},{"issue":"8","key":"2026040814495695600_bvag071-B48","doi-asserted-by":"crossref","first-page":"e13763","DOI":"10.1111\/obr.13763","article-title":"Corticotropin-releasing hormone and obesity: from fetal life to adulthood","volume":"25","author":"Vasconcelos","year":"2024","journal-title":"Obes Rev"},{"key":"2026040814495695600_bvag071-B49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2023.10.011","article-title":"Placental pathologic features in obesity","volume":"144","author":"Beneventi","year":"2023","journal-title":"Placenta"},{"issue":"3","key":"2026040814495695600_bvag071-B50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1084\/jem.20021343","article-title":"G-CSF-stimulated neutrophils are a prominent source of functional BLyS","volume":"197","author":"Scapini","year":"2003","journal-title":"J Exp Med"},{"issue":"1","key":"2026040814495695600_bvag071-B51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/jendso\/bvag071\/67720340\/bvag071.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/4\/bvag071\/67720340\/bvag071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jes\/article-pdf\/10\/4\/bvag071\/67720340\/bvag071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:50:12Z","timestamp":1775674212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/doi\/10.1210\/jendso\/bvag071\/8571893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3,6]]}},"URL":"https:\/\/doi.org\/10.1210\/jendso\/bvag071","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,6]]},"article-number":"bvag071"}}