{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:07:32Z","timestamp":1782144452512,"version":"3.54.5"},"reference-count":30,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018852","name":"L\u00fcbeck Hilfe f\u00fcr krebskranke Kinder e.V","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018852","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood, adolescent, and young adult cancer survivors (CAYA) are at an increased risk for metabolic disorders such as diabetes mellitus. Although this risk has been well-documented for leukemia survivors and those exposed to abdominal radiotherapy, the metabolic risk profile for brain tumor survivors remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study assessed the prevalence of diabetes and dysglycemia in 2 CAYA survivor cohorts. The first included medulloblastoma and ependymoma survivors (HIT-MED), with data collected via self-reported online questionnaires. The second (CLI) was a retrospective analysis of an unselected cohort from our late effects clinic. In this cohort, dysglycemia was defined using hemoglobin A1c measurements alone, without additional glucose-based diagnostic criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the HIT-MED group, 37% (197\/527) participated in an online-based questionnaire, revealing a diabetes mellitus prevalence of 3.05%. A total of 122 were male and 75 female, mean age was 27.1 \u00b1 4.5 years (range 19-41). In comparison to an age-matched general population, there was no significant difference (P = .468). Among survivors in the CLI group who received craniospinal irradiation (mean age 38 years at assessment), 34.6% (9\/26) exhibited dysglycemia, including 7.7% (2\/26) with diabetes mellitus and 26.9% (7\/26) with prediabetic glucose levels. This represented the second highest prevalence of impaired glucose regulation among all irradiation subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CAYA brain tumor survivors exposed to craniospinal radiotherapy have an elevated risk of dysglycemia compared to other survivor cohorts. These findings support the need for structured, risk-adapted long-term metabolic monitoring to enable early intervention and reduce long-term morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag116","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:09:21Z","timestamp":1781453361000},"source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of diabetes mellitus in long-term cancer survivors treated with craniospinal irradiation"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6921-7385","authenticated-orcid":false,"given":"Franziska","family":"Richter","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, University Medical Center Schleswig-Holstein , 23562 Luebeck 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