{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T06:02:07Z","timestamp":1780293727564,"version":"3.54.0"},"reference-count":43,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>New evidence has emerged linking uric acid levels to Chronic Kidney Disease and Mineral and Bone Disorder (CKD-MBD). However, interventional studies remain scarce. We evaluated the effect of allopurinol on CKD-MBD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a randomized, double-blind clinical trial involving adult patients with stage 3\u20135 CKD under conservative management. Participants received either allopurinol 300\u2005mg or a placebo for at least 90 days. Clinical data and blood samples were collected at baseline and at the end of the follow-up period to assess changes in calcium, phosphate, 25-hydroxyvitamin-D, parathyroid hormone (PTH), 1,25-hydroxyvitamin D, fibroblast growth factor 23 (FGF23), \u03b1 Klotho, and bone alkaline phosphatase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-nine patients completed the study (25 in the allopurinol group and 24 in the placebo group). Most participants were women (53.1%), with a mean age of 71 \u00b1 11 years and an average eGFR of 27.8 \u00b1 11.0\u2005mL\/min\/1.73\u2005m2. Uric acid levels were significantly decreased in the allopurinol group (7.49\u2005mg\/dL initial vs 3.96\u2005mg\/dL final, 43%, P &amp;lt; .001). FGF23 levels increased over time (P = .037), with no difference between groups. 25-hydroxyvitamin-D levels increased in the allopurinol group and decreased in the placebo group, a result that lost significance after adjusting for cholecalciferol supplementation and race. No other CKD-MBD biomarkers were significantly affected by allopurinol treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite its urate-lowering effect, allopurinol did not produce meaningful changes in the major CKD-MBD biomarkers over the study period. Our results strengthen existing recommendations to restrict uric acid-lowering treatment to symptomatic gout, as we did not identify any associated improvements in mineral metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag118","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:40:59Z","timestamp":1779277259000},"source":"Crossref","is-referenced-by-count":0,"title":["Allopurinol has no effect on calcitriol or other CKD-MBD biomarkers: a randomized double-blind study"],"prefix":"10.1210","volume":"10","author":[{"given":"Tiago E","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Laboratorio de Fisiopatologia Renal (LIM 16), Universidade de S\u00e3o Paulo, Hospital das Clinicas HCFMUSP , Sao Paulo, SP 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C","family":"Lauar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Laboratorio de Fisiopatologia Renal (LIM 16), Universidade de S\u00e3o Paulo, Hospital das Clinicas HCFMUSP , Sao Paulo, SP 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana L R","family":"Innecchi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Laboratorio de Fisiopatologia Renal (LIM 16), Universidade de S\u00e3o Paulo, Hospital das Clinicas HCFMUSP , Sao Paulo, SP 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Karla R P","family":"Araujo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Laboratorio de Fisiopatologia Renal (LIM 16), Universidade de S\u00e3o Paulo, Hospital das Clinicas HCFMUSP , Sao Paulo, SP 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venceslau A","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics, Hospital das Clinicas HCFMUSP , Sao Paulo, SP 05403-010 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene M","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Laboratorio de Fisiopatologia Renal (LIM 16), Universidade de S\u00e3o Paulo, Hospital das Clinicas HCFMUSP , Sao Paulo, SP 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M A","family":"Moys\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Laboratorio de Fisiopatologia Renal (LIM 16), Universidade de S\u00e3o Paulo, Hospital das Clinicas HCFMUSP , Sao Paulo, SP 01246-903 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