{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:43:32Z","timestamp":1790279012908,"version":"4.1.0"},"reference-count":68,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Joint and bone disorders are frequent, disabling complications of acromegaly that progress despite biochemical remission. HR-pQCT provides a precise assessment of bone and joint quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate joint and bone quality in patients with long-term controlled acromegaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>17 acromegaly patients and 17 age- and sex-matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measures<\/jats:title>\n                    <jats:p>HR-pQCT of hand joints, tibia, and radius; bone microindentation; vertebral fracture assessment; dual X-ray absorptiometry; circulating bone biomarkers; questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with acromegaly (mean age: 61.8 years, mean disease duration: 13.1 years, mean IGF-I xULN: 0.9) had wider joint spaces of the second (2.85 vs 2.68\u2005mm, P = .004) and third (2.92 vs 2.80\u2005mm, P = .037) metacarpophalangeal joints, the latter with a higher risk of osteophytes (50% vs 11.8%, P = .017). Vertebral deformities were more common (88% vs 47%, P = .01), more numerous (2.1 vs 0.7, P &amp;lt; .001), and associated with higher spinal deformity indices (2.6 vs 1.3, P = .04) in participants with acromegaly. HR-pQCT demonstrated lower trabecular bone mineral density in the radius (114.8 vs 150.3\u2005mg\/cm3, P = .008) and tibia (129.3 vs 166.2\u2005mg\/cm3, P = .002), as well as fewer (1.63 vs 2.11\u2005mm\u22121, P = .001) and thinner (0.056 vs 0.064\u2005mm, P = .005) trabeculae. Bone and joint abnormalities increased with age, and the spinal deformity index correlated positively with arthropathy indices, only in the acromegaly group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term, biochemically controlled acromegaly is associated with structural joint alterations and impaired bone microarchitecture, even years after diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag135","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:54:25Z","timestamp":1781870065000},"source":"Crossref","is-referenced-by-count":1,"title":["Bone and joint quality remains impaired in long-term controlled acromegaly: an HR-pQCT study"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-4387","authenticated-orcid":false,"given":"Christian","family":"Rosendal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , Gistrup 9260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5627-598X","authenticated-orcid":false,"given":"Frederik \u00d8stergaard","family":"Klit","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , Gistrup 9260 ,","place":["Denmark"]},{"name":"Steno Diabetes Center North Denmark, Aalborg University Hospital , Gistrup 9260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-544X","authenticated-orcid":false,"given":"Annika Vestergaard","family":"Kvist","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark, Aalborg University Hospital , Gistrup 9260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-2967","authenticated-orcid":false,"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark, Aalborg University Hospital , Gistrup 9260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0610-7867","authenticated-orcid":false,"given":"Jakob","family":"Dal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , Gistrup 9260 ,","place":["Denmark"]},{"name":"Steno Diabetes Center North Denmark, Aalborg University Hospital , Gistrup 9260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"4","key":"2026070709563310200_bvag135-B1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s11154-024-09875-z","article-title":"The changing landscape of acromegaly\u2014an epidemiological perspective","volume":"25","author":"Rosendal","year":"2024","journal-title":"Rev Endocr Metab Disord"},{"issue":"6","key":"2026070709563310200_bvag135-B2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/cen.14828","article-title":"The prevalence of acromegaly is higher than previously reported: changes over a three-decade period","volume":"97","author":"Aagaard","year":"2022","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2026070709563310200_bvag135-B3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ecl.2007.10.002","article-title":"Acromegaly","volume":"37","author":"Ben-Shlomo","year":"2008","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"2026070709563310200_bvag135-B4","doi-asserted-by":"crossref","first-page":"E937","DOI":"10.1210\/clinem\/dgz096","article-title":"A consensus on the diagnosis and treatment of acromegaly comorbidities: an update","volume":"105","author":"Giustina","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026070709563310200_bvag135-B5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11102-025-01509-0","article-title":"Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature","volume":"28","author":"Matthesen","year":"2025","journal-title":"Pituitary"},{"issue":"2","key":"2026070709563310200_bvag135-B6","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1093\/ejendo\/lvad097","article-title":"The socioeconomic burden of acromegaly","volume":"189","author":"St\u00f6rmann","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2026070709563310200_bvag135-B7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3897\/folmed.65.e68278","article-title":"Association between pain, arthropathy and health-related quality of life in patients suffering from acromegaly. 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