{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:07:05Z","timestamp":1785506825811,"version":"3.56.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011997","name":"Spanish Society of Endocrinology & Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the impact of body mass index (BMI) on disease severity, cardiac remodeling, and clinical and biochemical outcomes after surgical and medical treatment in patients with primary aldosteronism (PA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This international retrospective study included patients diagnosed with PA in Germany, Italy, and Spain. Patients with available BMI, serum potassium, blood pressure, and basal plasma aldosterone concentration at diagnosis were included. PA severity was classified using the Primary Aldosteronism Severity Classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1752 patients were analyzed at baseline; 604 (34.5%) had obesity (BMI \u226530\u2005kg\/m2). Patients with obesity were older, more frequently male, and had a higher prevalence of cardiometabolic comorbidities, including type 2 diabetes, cardiovascular disease, left ventricular hypertrophy, and obstructive sleep apnea. PA severity according to the Primary Aldosteronism Severity Classification did not differ significantly between patients with and without obesity; however, the prevalence of severe PA increased progressively across BMI categories (MH test for linear trend: \u03c72(1) = 3.70, P = .054). Following adrenalectomy, the probability of complete hypertension resolution decreased with increasing BMI, whereas biochemical cure rates were similar. Among patients treated with mineralocorticoid receptor antagonists, obesity was associated with a lower likelihood of complete clinical response, without significant differences in biochemical response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with PA, obesity is associated with a higher burden of cardiometabolic comorbidities and increased prevalence of left ventricular hypertrophy at baseline, as well as with less favorable clinical outcome after both surgical and medical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag142","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:23:29Z","timestamp":1784190209000},"source":"Crossref","is-referenced-by-count":0,"title":["Influence of body mass index on disease severity and treatment outcomes in primary aldosteronism"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"first","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4985-1546","authenticated-orcid":false,"given":"Jessica","family":"Goi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Burrello","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino , Torino 10124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-2005","authenticated-orcid":false,"given":"Silvia","family":"Monticone","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino , Torino 10124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-1116","authenticated-orcid":false,"given":"Paolo","family":"Mulatero","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino , Torino 10124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bersano","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino , Torino 10124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-0951","authenticated-orcid":false,"given":"Holger","family":"Schneider","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine IV, LMU University Hospital , Munich 80336 ,","place":["Germany"]},{"name":"Division of Vascular Medicine, Department of Medicine IV, LMU University Hospital , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Johann Petersenn","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine IV, LMU University Hospital , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Zopp","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine IV, LMU University Hospital , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Capuzzo","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino , Torino 10124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Garc\u00eda Cano","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mena Ribas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Son Espases , Palma, Islas Baleares 07120 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Sanmart\u00edn S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department 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,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Garc\u00eda Centero","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Gregorio Mara\u00f1on , Madrid 28007 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Torres","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Gregorio Mara\u00f1on , Madrid 28007 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonsoles","family":"Guti\u00e9rrez-Medina","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, CUN Madrid , Madrid 28027 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aster","family":"Adel Gamil","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital de Toledo , Toledo 45007 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-9875","authenticated-orcid":false,"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine IV, LMU University Hospital , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0310-7095","authenticated-orcid":false,"given":"Paola","family":"Parra Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario La Paz , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"14","key":"2026073109214767400_bvag142-B1","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical 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