{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:44:49Z","timestamp":1790207089832,"version":"4.1.0"},"reference-count":55,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Astellas BV"},{"DOI":"10.13039\/100007560","name":"Chiesi Pharmaceuticals BV","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"NWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024872","name":"TTW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024872","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Animal Nutrition and Health"},{"DOI":"10.13039\/501100016238","name":"Dutch Ministry of Economic Affairs and Climate Policy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The triglyceride-glucose (TyG) index is a widely used surrogate marker of insulin resistance and associated with cardiometabolic outcomes. However, the comparative prognostic value of TyG-derived indices, particularly those incorporating anthropometric measures or long-term variability, for adverse outcomes after kidney transplantation remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the prognostic performance of 15 TyG-derived indices for predicting new-onset diabetes after transplantation (NODAT), graft failure, and all-cause mortality in kidney transplant recipients (KTRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This prospective observational study was conducted within the TransplantLines Biobank and Cohort study and included 464 KTRs (median age, 56.9 years; 65.1% male) followed for a median of 71 months. Fifteen TyG-derived indices were classified into metabolic, anthropometry-adjusted, and variability-based domains. Their prognostic performance was assessed using an analytical framework integrating machine learning with conventional statistical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparative analyses identified 4 indices, TyG-WWI, TyG-WHR, TyG mean, and TyG-BMI, as having superior predictive performance. Among them, anthropometry-adjusted indices (TyG-WHR and TyG-WWI) showed the most stable associations across 3 outcomes. In multivariable analyses, TyG-WHR independently predicted NODAT (HR 2.30, 95% CI 1.21-4.39), graft failure (HR 2.22, 95% CI 1.18-4.18), and mortality (HR 1.87, 95% CI 1.19-2.96), while TyG-WWI independently predicted mortality (HR 2.07, 95% CI 1.11-3.86). Cross-validation showed no consistent advantage of combined models over single well-performing indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among adult KTRs from the TransplantLines cohort with a functioning graft, TyG-WWI and TyG-WHR showed the most consistent associations with adverse post-transplant outcomes. Their potential role as complementary metabolic risk markers requires validation in larger and more diverse transplant cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag157","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:53:22Z","timestamp":1783511602000},"source":"Crossref","is-referenced-by-count":2,"title":["Anthropometry-adjusted TyG indices predict diabetes, graft failure, and mortality in kidney transplant recipients"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2430-3711","authenticated-orcid":false,"given":"Jiachuan","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]},{"name":"Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University) , Chongqing 400037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-9234","authenticated-orcid":false,"given":"Tamas","family":"Szili-Torok","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer Tarik","family":"\u00d6zyilmaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]},{"name":"Bernoulli Institute for Mathematics, Computer Science, and Artificial Intelligence, University of Groningen , 9747 AG Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juul S","family":"Daamen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9548-4985","authenticated-orcid":false,"given":"Jip","family":"Jonker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-4451","authenticated-orcid":false,"given":"Dion","family":"Groothof","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-115X","authenticated-orcid":false,"given":"Daan","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-4877","authenticated-orcid":false,"given":"Antonio Gomes","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Pol","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-8733","authenticated-orcid":false,"given":"Martin H","family":"de Borst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J 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