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Few studies have evaluated associations between EDCs and gestational blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate associations between EDC biomarkers with gestational blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Environmental Reproductive and Glucose Outcomes study (N = 338) measured urinary concentrations of 18 phthalate and replacement metabolites and systolic (SBP) and diastolic (DBP) blood pressure at 3 pregnancy study visits (median: 12, 19, and 26 weeks\u2019 gestation). Individual metabolite concentrations and summary measures based on common source or mechanism (eg, \u03a3Personal care products [\u03a3PCP]) were log2-transformed, specific-gravity corrected, and modeled continuously and in quartiles. We estimated covariate-adjusted associations of individual metabolites and, summary measures with blood pressure using linear regression, and with HDP using log-binomial regression, assessing metabolite mixtures using Bayesian Kernel Machine Regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HDP prevalence was 12.7%. Higher concentrations of monoethyl phthalate (MEP) and \u03a3PCP were most consistently associated with SBP and DBP elevations at visit 3. Higher concentrations of MEP (Q4 vs Q1) were associated with 4.59\u2005mmHg higher SBP (95% CI: 0.04, 9.15), and higher \u03a3PCP (Q3 vs Q1) were associated with 5.78\u2005mmHg (95% CI: 1.59, 9.97). Higher MEP and \u03a3PCP (Q4 vs Q1) were positively linked to DBP elevations of 4.51 to 4.70\u2005mmHg. Other phthalate biomarkers were associated with blood pressure at specific time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Certain urinary phthalate biomarkers, particularly MEP and \u03a3PCP, were associated with higher blood pressure levels in pregnancy, with implications for HDP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag158","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:52:55Z","timestamp":1783684375000},"source":"Crossref","is-referenced-by-count":1,"title":["Associations of urinary phthalate metabolite and replacement chemical concentrations with gestational blood pressure"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-6005","authenticated-orcid":false,"given":"Kimberly L","family":"Parra","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. 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Chan School of Public Health , Boston, MA 02115 ,","place":["USA"]},{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele R","family":"Hacker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA 02115 ,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-0107","authenticated-orcid":false,"given":"Thomas F","family":"McElrath","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA 02115 ,","place":["USA"]},{"name":"Division of Maternal Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Cantonwine","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-7482","authenticated-orcid":false,"given":"Antonia M","family":"Calafat","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, GA 30333 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne","family":"Cook Botelho","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, GA 30333 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair J","family":"Wylie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille E","family":"Powe","sequence":"additional","affiliation":[{"name":"Diabetes Unit, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 ,","place":["USA"]},{"name":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 ,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen W","family":"Seely","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-5169","authenticated-orcid":false,"given":"Tamarra","family":"James-Todd","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. 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