{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T03:30:20Z","timestamp":1786332620233,"version":"build-2736575974"},"reference-count":38,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"BRIDGE\u2014Translational Excellence Programme"},{"DOI":"10.13039\/501100009317","name":"Faculty of Health and Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","award":["NNF23SA0084103"],"award-info":[{"award-number":["NNF23SA0084103"]}],"id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20SA0064340"],"award-info":[{"award-number":["NNF20SA0064340"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshall\u2019s foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"name":"T\u00f8mmerhandler Vilhelm Bangs foundation"},{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Centre for Basic Metabolic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children with cerebral palsy (CP) and spinal muscular atrophy (SMA) are at high risk of low bone mineral density, fractures, and low muscle mass. The gut-derived hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) reduce bone resorption in adults, but their effects in pediatric populations with CP and SMA are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this preliminary study, 3 children (1 CP and 2 SMA) underwent 3 interventions: (1) oral liquid mixed-meal ingestion, (2) subcutaneous GIP+GLP-2 administration, and (3) placebo. Plasma levels of GIP, GLP-2, CTX (bone resorption), P1NP (bone formation), and parathyroid hormone (PTH) were measured over 240\u2005minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The liquid mixed-meal significantly reduced CTX levels, indicating suppressed bone resorption, while exogenous GIP+GLP-2 administration had no significant effect on CTX or P1NP. PTH levels decreased after GIP+GLP-2 administration but were unaffected by the liquid mixed-meal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In these studies, exogenous GIP and GLP-2 unexpectedly did not modulate bone turnover in our children with CP or SMA. The study highlights the need for age- and disease-specific investigations into the gut\u2013bone axis in pediatric populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag168","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:20:47Z","timestamp":1785151247000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of GIP and GLP-2 on bone turnover in children with cerebral palsy or spinal muscular atrophy"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9496-801X","authenticated-orcid":false,"given":"Charlotte B","family":"Christiansen","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen DK-2200 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