{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:50:57Z","timestamp":1790279457816,"version":"4.1.0"},"reference-count":47,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019256","name":"NIHR Great Ormond Street Hospital BRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030827","name":"NHS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022513","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022513","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Translational and Clinical Omics Group"},{"name":"Genetics and Genomic Medicine"},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001282","name":"Great Ormond Street Institute of Child Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001282","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academic Department of Adolescent Medicine"},{"name":"The Children\u2019s Hospital at Westmead","id":[{"id":"https:\/\/ror.org\/05k0s5494","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Adolescent Health"},{"DOI":"10.13039\/501100008721","name":"University College London Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose and Methods<\/jats:title>\n                    <jats:p>Polyendocrine metabolic ovarian syndrome (PMOS) affects 10% to 26% of adolescent females. Yet, its pathogenesis is poorly understood. Proteomics is a valuable tool to explore biological pathways underpinning PMOS and identify novel diagnostic\/monitoring biomarkers. We undertook deep-phenotyping discovery proteomic profiling (nanoflow 2-dimensional liquid chromatography\u2013quadrupole time-of-flight mass spectrometry with alternating low- and elevated-energy acquisition) on urine samples from a subset of a longitudinal adolescent PMOS cohort (n = 40). We compared the urinary proteome of adolescents (12-19 years, \u22651-year postmenarche) recruited from adolescent endocrinology\/gynecology clinics with PMOS or insulin resistance (IR), and community-recruited age-, sex-, and puberty-matched controls. PMOS was defined by adolescent-specific criteria (irregular menstrual cycles and hyperandrogenism). Exclusion criteria included the combined oral contraceptive pill. Results were validated in the whole cohort with a multiplexed targeted proteomic panel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Discovery proteomic analysis identified 3793 proteins, of which 66 were differentially expressed in the PMOS cohort vs IR and controls (candidate PMOS biomarkers). Bioinformatic analysis revealed that almost half of the PMOS-associated biological pathways were related to inflammatory\/immunological responses. The inflammatory response was the most significant biological process (P &amp;lt; .001). Targeted proteomic analysis of 89 known inflammatory-associated proteins validated this association. Multivariate analysis demonstrated a distinct inflammatory proteome in adolescent PMOS.<\/jats:p>\n                    <jats:p>Twenty inflammatory-associated proteins were differentially expressed in the PMOS cohort vs IR and control groups, with notable roles in oxidative stress and neuroinflammation. Six proteins were significantly different in PMOS compared with both IR and control cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These analyses provide insight into the pathophysiology of PMOS, highlighting inflammatory processes as a prominent feature of adolescent PMOS and identifying several candidate novel noninvasive biomarkers and drug targets that need further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag203","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:20:57Z","timestamp":1788412857000},"source":"Crossref","is-referenced-by-count":1,"title":["Inflammation and polyendocrine metabolic ovarian syndrome: utilizing proteomics to unravel this link in adolescents"],"prefix":"10.1210","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-6297","authenticated-orcid":false,"given":"Harriet M","family":"Gunn","sequence":"first","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health Genetics and Genomic Medicine Department, , London WC1N 1EH ,","place":["UK"]},{"name":"Academic Department of Adolescent Medicine, The Children's Hospital at Westmead , Sydney, NSW 2145 ,","place":["Australia"]},{"name":"University College London Hospital Children and Young People's Endocrinology Service, , London NW1 2BU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-3211","authenticated-orcid":false,"given":"Jenny","family":"H\u00e4llqvist","sequence":"additional","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health Genetics and Genomic Medicine Department, , London WC1N 1EH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4580-6396","authenticated-orcid":false,"given":"Ivan","family":"Doykov","sequence":"additional","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health Genetics and Genomic Medicine Department, , London WC1N 1EH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-8760","authenticated-orcid":false,"given":"Wendy","family":"Heywood","sequence":"additional","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health Genetics and Genomic Medicine Department, , London WC1N 1EH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-2247","authenticated-orcid":false,"given":"Russell","family":"Viner","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health Population, Policy and Practice Department, , London WC1N 1EH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1099-0522","authenticated-orcid":false,"given":"Katharine","family":"Steinbeck","sequence":"additional","affiliation":[{"name":"Academic Department of Adolescent Medicine, The Children's Hospital at Westmead , Sydney, NSW 2145 ,","place":["Australia"]},{"name":"Discipline of Child and Adolescent Health, The University of Sydney , Sydney 2006 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0763-8288","authenticated-orcid":false,"given":"Kevin","family":"Mills","sequence":"additional","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health Genetics and Genomic Medicine Department, , London WC1N 1EH 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