{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:06Z","timestamp":1792788546440,"version":"4.5.0"},"reference-count":23,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["23CDA1054471"],"award-info":[{"award-number":["23CDA1054471"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R01DK075787"],"award-info":[{"award-number":["R01DK075787"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Medical Research Council and Wellcome Trust","award":["217065\/Z\/19\/Z"],"award-info":[{"award-number":["217065\/Z\/19\/Z"]}],"id":[{"id":"https:\/\/ror.org\/03x94j517","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M009351\/1"],"award-info":[{"award-number":["MR\/M009351\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Center for Disease Control","doi-asserted-by":"publisher","award":["AY5350"],"award-info":[{"award-number":["AY5350"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp","id":[{"id":"https:\/\/ror.org\/05cy4wa09","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Diagnosing polycystic ovary syndrome, recently renamed polyendocrine metabolic ovarian syndrome (PMOS), during adolescence is challenging because menstrual irregularity and clinical signs suggesting hyperandrogenism are common. Recent international recommendations highlighted an \u201cat risk for PMOS\u201d category, defined by either menstrual regularity or hyperandrogenism, to guide surveillance; however, its prevalence and genetic correlates remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the prevalence of PMOS and \u201cat risk for PMOS\u201d in adolescence and young adulthood and to assess associations with genetic risk for PMOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Setting\/Participants<\/jats:title>\n                    <jats:p>Retrospective analysis of 1533 participants from the ALSPAC study, a UK birth cohort, with sufficient data to classify menstrual regularity and hyperandrogenism, and a subset of 1371 genotyped participants of European ancestry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Prevalence of PMOS and \u201cat risk for PMOS\u201d and associations with a PMOS polygenic score (PGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1533 participants, 49 (3%) met criteria for PMOS and 417 (27%) were \u201cat risk for PMOS\u201d (hyperandrogenism only, 276 [18%]; irregular menses only, 141 [9%]). A higher PMOS PGS was associated with hyperandrogenism only (OR per SD: 1.22; 95% CI: 1.07-1.39; P = 4 \u00d7 10\u22123) but not with irregular menses only (OR: 0.98; 95% CI: 0.83-1.15; P = .8). The association with PMOS was positive but not statistically significant (OR: 1.28; 95% CI: 0.88-1.87; P = .2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PMOS prevalence in adolescence and young adulthood was 3%, whereas over one-quarter met criteria for being \u201cat risk for PMOS.\u201d Genetic risk for PMOS was associated with hyperandrogenism but not isolated menstrual irregularity, suggesting androgen excess may represent a more specific early manifestation of inherited PMOS liability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag204","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:29:44Z","timestamp":1788258584000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic risk for PCOS\/PMOS is associated with hyperandrogenism but not irregular menses in adolescents and young 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