{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:55:14Z","timestamp":1790751314901,"version":"4.1.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Time-restricted eating (TRE) is a lifestyle intervention associated with beneficial cardiometabolic effects. The impact of TRE-induced weight reduction on thyroid hormonal responses is not well elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of TRE accompanied by weight loss on thyroid function in adults with obesity and type 2 diabetes (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an exploratory analysis of a randomized, crossover, open-label study in adults with obesity and T2DM who underwent 2 dietary interventions: TRE and standard lifestyle. Each intervention period lasted 6 weeks. Thyroid function was assessed by TSH, free T4 (fT4), free T3 (fT3), and reverse T3 (rT3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-nine participants without known thyroid disease (age 56.3 years, 35.9% male, body mass index 32.4 \u00b1 5.7\u2005kg\/m2) were included. TRE induced significant weight loss (\u22122.93\u2005kg) compared to the standard lifestyle period (0.59\u2005kg) (mean differences between intervention periods of \u22123.50\u2005kg \u00b1 2.9; P &amp;lt; .001). Despite this robust weight-lowering effect, there were no significant differences in TSH (0.49\u2005mUI\/L \u00b1 3.0; P = .32), fT3 (\u22120.57\u2005pmol\/L \u00b1 2.7; P = .19), fT4 (fT4 \u22120.55\u2005pmol\/L \u00b1 3.8; P = .38), and rT3 (\u22120.94\u2005ng\/dL \u00b1 5.9; P = .350) between intervention periods. Reinforcing these findings, there was no treatment effect interaction on any thyroid function test evaluated. In addition, there was no significant change in the fT3: fT4 and fT3:rT3 ratios between treatment interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite inducing significant weight loss, TRE did not exert a significant effect on thyroid function in individuals with obesity and early T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvag216","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:19:21Z","timestamp":1789672761000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of time-restricted eating accompanied by weight loss on thyroid function in adults with type 2 diabetes"],"prefix":"10.1210","volume":"10","author":[{"given":"Yaanu","family":"Jeyakumar","sequence":"first","affiliation":[{"name":"Leadership Sinai Centre for Diabetes, Mount Sinai Hospital , Toronto M5T 3L9 ,","place":["Canada"]},{"name":"Division of Endocrinology, University of Toronto , Toronto M5T 3L9 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Retnakaran","sequence":"additional","affiliation":[{"name":"Leadership Sinai Centre for Diabetes, Mount Sinai Hospital , Toronto M5T 3L9 ,","place":["Canada"]},{"name":"Division of Endocrinology, University of Toronto , Toronto M5T 3L9 ,","place":["Canada"]},{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital , Toronto M5T 3L9 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denice S","family":"Feig","sequence":"additional","affiliation":[{"name":"Leadership Sinai Centre for Diabetes, Mount Sinai Hospital , Toronto M5T 3L9 ,","place":["Canada"]},{"name":"Division of Endocrinology, University of Toronto , Toronto M5T 3L9 ,","place":["Canada"]},{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital , Toronto M5T 3L9 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